ID   VE8E2_HPV57             Reviewed;         192 AA.
AC   P0DKA8;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-JAN-2017, sequence version 1.
DT   02-JUN-2021, entry version 22.
DE   RecName: Full=Protein E8^E2C;
OS   Human papillomavirus 57.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Alphapapillomavirus.
OX   NCBI_TaxID=333753;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1964523; DOI=10.1016/0168-1702(90)90091-o;
RA   Hirsch-Behnam A., Delius H., de Villiers E.M.;
RT   "A comparative sequence analysis of two human papillomavirus (HPV) types 2a
RT   and 57.";
RL   Virus Res. 18:81-98(1990).
CC   -!- FUNCTION: Plays a role in limiting the replication of viral DNA in
CC       keratinocytes. Recruits the host NCoR/SMRT complex to viral replication
CC       foci to mediate repression of both viral replication and transcription.
CC       {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E8^E2C protein family.
CC       {ECO:0000305}.
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DR   EMBL; X55965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0DKA8; -.
DR   Proteomes; UP000007667; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR035975; E2/EBNA1_C_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR000427; Papillomavirus_E2_C.
DR   Pfam; PF00511; PPV_E2_C; 1.
DR   SUPFAM; SSF54957; SSF54957; 1.
PE   3: Inferred from homology;
KW   Host nucleus.
FT   CHAIN           1..192
FT                   /note="Protein E8^E2C"
FT                   /id="PRO_0000438748"
FT   REGION          38..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..106
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   192 AA;  21423 MW;  A02C30E51BDC8BB5 CRC64;
     MAIRRWLLER QKSTQAATSD DDTLSPLRSA AAAVTATATA TTAVPPTLQD SAQAPSSPPP
     KRQRVIVGQQ WQQPDSTRKV REGQVECQND RSIRNPDSTD PRRGHSDLDA VPVIHLQGEA
     NCLKCFRYRV QKHKDVLFVK ASSTWHWACG NGDKTAFVTL WYKSQEQRAE FLTRVHLPKG
     VKALPGYMSA FV