ID   VE8E2_MNPVA             Reviewed;         351 AA.
AC   P0DOD9;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-JAN-2017, sequence version 1.
DT   02-JUN-2021, entry version 16.
DE   RecName: Full=Protein E8^E2C;
OS   Mastomys natalensis papillomavirus (isolate African multimammate rat)
OS   (MnPV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Iotapapillomavirus.
OX   NCBI_TaxID=654915;
OH   NCBI_TaxID=10112; Mastomys natalensis (African soft-furred rat) (Praomys natalensis).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8291235; DOI=10.1006/viro.1994.1064;
RA   Tan C.-H., Tachezy R., van Ranst M., Chan S.-Y., Bernard H.-U., Burk R.D.;
RT   "The Mastomys natalensis papillomavirus: nucleotide sequence, genome
RT   organization, and phylogenetic relationship of a rodent papillomavirus
RT   involved in tumorigenesis of cutaneous epithelia.";
RL   Virology 198:534-541(1994).
CC   -!- FUNCTION: Plays a role in limiting the replication of viral DNA in
CC       keratinocytes. Recruits the host NCoR/SMRT complex to viral replication
CC       foci to mediate repression of both viral replication and transcription.
CC       {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:P0DKA0}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E8^E2C protein family.
CC       {ECO:0000305}.
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DR   EMBL; U01834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0DOD9; -.
DR   Proteomes; UP000007018; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR035975; E2/EBNA1_C_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR000427; Papillomavirus_E2_C.
DR   Pfam; PF00511; PPV_E2_C; 1.
DR   SUPFAM; SSF54957; SSF54957; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..351
FT                   /note="Protein E8^E2C"
FT                   /id="PRO_0000438764"
FT   REGION          11..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..163
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  39270 MW;  939899007949A8F8 CRC64;
     MRLQILLRGF SSTPQTGFPR GDPVRLHGNT TTGLPIPLRN SSSNQILLRE GRGDYPDGAR
     RETRRYYQGP TPTPRSLSPP IYRPPPSYEE SRRRRKLRRR QDGRVKYPAS PYRTKPPGET
     SSDDEDEGRG GHEPRPQRRL PRGLRDRGER APERRRPPVQ EGEEDVDGVG ALLDDLKLYQ
     EPPGDPVEDS DSPGSRLTPA PPDLSRYDST RLQVDAESSP PRTPRPAPTL VAECTPGRPS
     PQTGSGQQAL GEPPSRPSRG HCRDPRTACL LIIKGSSNQV KCLRFRLKSW HHSLFSYIST
     TWQWVPSVGS NRIGRSRILV MCEDSAQMDR FLCTVKIPAG MTVEQCSMAS V