VEA_ASPOR
ID VEA_ASPOR Reviewed; 574 AA.
AC Q2UNT7;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 57.
DE RecName: Full=Developmental and secondary metabolism regulator veA {ECO:0000305};
DE AltName: Full=Velvet complex subunit A {ECO:0000305};
GN Name=veA {ECO:0000303|PubMed:20541108}; ORFNames=AO090001000237;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20541108; DOI=10.1016/j.jbiosc.2010.01.001;
RA Marui J., Ohashi-Kunihiro S., Ando T., Nishimura M., Koike H., Machida M.;
RT "Penicillin biosynthesis in Aspergillus oryzae and its overproduction by
RT genetic engineering.";
RL J. Biosci. Bioeng. 110:8-11(2010).
CC -!- FUNCTION: Component of the velvet transcription factor complex that
CC controls sexual/asexual developmental ratio in response to light,
CC promoting sexual development in the darkness while stimulating asexual
CC sporulation under illumination (By similarity). The velvet complex hat
CC acts as a global regulator for secondary metabolite gene expression
CC (PubMed:20541108). Controls the expression of the penicillin gene
CC cluster (PubMed:20541108). {ECO:0000250|UniProtKB:C8VTV4,
CC ECO:0000269|PubMed:20541108}.
CC -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC laeA, veA and velB; VeA acting as a bridging protein between laeA and
CC velB (By similarity). {ECO:0000250|UniProtKB:C8VTV4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTV4}. Cytoplasm
CC {ECO:0000250|UniProtKB:C8VTV4}. Note=Enriched in the nucleus in the
CC dark (By similarity). {ECO:0000250|UniProtKB:C8VTV4}.
CC -!- DOMAIN: The C-terminal PEST domain is a region rich in proline,
CC glutamic acid, serine and threonine residues that is required for the
CC light-dependent regulation of development and secondary metabolism (By
CC similarity). {ECO:0000250|UniProtKB:C8VTV4}.
CC -!- DISRUPTION PHENOTYPE: Reduces the production of penicillin
CC (PubMed:20541108). {ECO:0000269|PubMed:20541108}.
CC -!- SIMILARITY: Belongs to the velvet family. VeA subfamily. {ECO:0000305}.
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DR EMBL; AP007154; BAE56778.1; -; Genomic_DNA.
DR RefSeq; XP_001818780.1; XM_001818728.2.
DR AlphaFoldDB; Q2UNT7; -.
DR SMR; Q2UNT7; -.
DR STRING; 510516.Q2UNT7; -.
DR EnsemblFungi; BAE56778; BAE56778; AO090001000237.
DR GeneID; 5990751; -.
DR KEGG; aor:AO090001000237; -.
DR VEuPathDB; FungiDB:AO090001000237; -.
DR HOGENOM; CLU_022491_2_0_1; -.
DR OMA; NFFLYAT; -.
DR Proteomes; UP000006564; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0033246; P:positive regulation of penicillin metabolic process; IMP:AspGD.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.3960; -; 1.
DR InterPro; IPR021740; Velvet.
DR InterPro; IPR037525; Velvet_dom.
DR InterPro; IPR038491; Velvet_dom_sf.
DR PANTHER; PTHR33572; PTHR33572; 1.
DR Pfam; PF11754; Velvet; 2.
DR PROSITE; PS51821; VELVET; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..574
FT /note="Developmental and secondary metabolism regulator
FT veA"
FT /id="PRO_0000435761"
FT DOMAIN 25..230
FT /note="Velvet"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..501
FT /note="PEST"
FT /evidence="ECO:0000250|UniProtKB:C8VTV4"
FT REGION 513..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 39..44
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:C8VTV4"
FT COMPBIAS 274..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..342
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 63016 MW; 673D213DFF939B9C CRC64;
MATRAPLAPP PNETEASVSR ITREGKKLTY KLNVMQQPER ARACGAGAKS SADRRPVDPP
PVVELRVYES DPNDDLNKTD ITFAYNANFF LYATLETARP MAQGRFAPNP TCPVLTGVPV
AGVAYLDRPS QAGYFIFPDL SVRHEGVYRL NFHLYEETKE SKDANENAPI QSLSNPMPSK
PMAPKSFLEF RLEVVSVPFT VFSAKKFPGL ATSTSLSRVI AEQGCRVRIR RDVRMRRRGE
KRTDDYDYDE ERVYRSSDRI STPDTHGYAG TPVERPRSTS TSTVDPSFPY GVDAQRRSSG
ATEYGFQGAQ PYQRPLPPAP GPAPAAVSTP APPAPPAPPS HNPGYQSHLS FGSTQTQYPA
PQLPPTPQTA STLAAPYSPH PSYSHARNPS TSAEYETPGY SYPPSRMSTE RSSYPKNGLP
PLRLEPPKPL NMPSGEPRSS DPNAYHSVAQ SAAPRSQTPS SSLVPSLPPL KALSGDYPNN
LSQSSSSTSQ SPSHDLGAGK KFFWDTGASL SKRSYEDSFG HDDRPLYNGM RPDTESYPRR
LSDASRNFYN ETRDEMAYKR ANGRMATKIS PALQ
