VEA_EMENI
ID VEA_EMENI Reviewed; 573 AA.
AC C8VTV4; O74625;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 16-MAR-2016, sequence version 2.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Developmental and secondary metabolism regulator veA {ECO:0000305};
DE AltName: Full=Velvet complex subunit A {ECO:0000305};
GN Name=veA {ECO:0000303|PubMed:12223191}; ORFNames=ANIA_01052;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RA Yager L.N., Kennedy P.A.;
RT "The veA gene is required for light-dependent conidiation in Emericella
RT (Aspergillus) nidulans.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INDUCTION, FUNCTION, AND
RP DISRUPTION PHENOTYPE.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=12223191; DOI=10.1016/s1087-1845(02)00029-4;
RA Kim H.-S., Han K.-Y., Kim K.-J., Han D.-M., Jahng K.-Y., Chae K.-S.;
RT "The veA gene activates sexual development in Aspergillus nidulans.";
RL Fungal Genet. Biol. 37:72-80(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC {ECO:0000312|Proteomes:UP000000560};
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC {ECO:0000312|Proteomes:UP000000560};
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [5]
RP FUNCTION.
RX PubMed=2253875; DOI=10.1101/gad.4.9.1473;
RA Mooney J.L., Yager L.N.;
RT "Light is required for conidiation in Aspergillus nidulans.";
RL Genes Dev. 4:1473-1482(1990).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=2076818; DOI=10.1093/genetics/126.4.869;
RA Mooney J.L., Hassett D.E., Yager L.N.;
RT "Genetic analysis of suppressors of the veA1 mutation in Aspergillus
RT nidulans.";
RL Genetics 126:869-874(1990).
RN [7]
RP DISRUPTION PHENOTYPE.
RX PubMed=9691036; DOI=10.1093/genetics/149.4.1777;
RA Yager L.N., Lee H.O., Nagle D.L., Zimmerman J.E.;
RT "Analysis of fluG mutations that affect light-dependent conidiation in
RT Aspergillus nidulans.";
RL Genetics 149:1777-1786(1998).
RN [8]
RP FUNCTION.
RX PubMed=12375102; DOI=10.1007/s00203-002-0463-x;
RA Jeong H.Y., Song M.H., Back J.H., Han D.M., Wu X., Monnier V., Jahng K.Y.,
RA Chae K.S.;
RT "The veA gene is necessary for the inducible expression by fructosyl amines
RT of the Aspergillus nidulans faoA gene encoding fructosyl amino acid oxidase
RT (amadoriase, EC 1.5.3).";
RL Arch. Microbiol. 178:344-350(2002).
RN [9]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=14665453; DOI=10.1128/ec.2.6.1178-1186.2003;
RA Kato N., Brooks W., Calvo A.M.;
RT "The expression of sterigmatocystin and penicillin genes in Aspergillus
RT nidulans is controlled by veA, a gene required for sexual development.";
RL Eukaryot. Cell 2:1178-1186(2003).
RN [10]
RP FUNCTION.
RX PubMed=12620259; DOI=10.1016/s1087-1845(02)00527-3;
RA Jeong H.Y., Kim H., Han D.M., Jahng K.Y., Chae K.S.;
RT "Expression of the mnpA gene that encodes the mannoprotein of Aspergillus
RT nidulans is dependent on fadA and flbA as well as veA.";
RL Fungal Genet. Biol. 38:228-236(2003).
RN [11]
RP FUNCTION.
RX PubMed=17375284; DOI=10.1007/s00203-007-0224-y;
RA Sproete P., Brakhage A.A.;
RT "The light-dependent regulator velvet A of Aspergillus nidulans acts as a
RT repressor of the penicillin biosynthesis.";
RL Arch. Microbiol. 188:69-79(2007).
RN [12]
RP SUBCELLULAR LOCATION.
RX PubMed=17163983; DOI=10.1111/j.1365-2958.2006.05506.x;
RA Stinnett S.M., Espeso E.A., Cobeno L., Araujo-Bazan L., Calvo A.M.;
RT "Aspergillus nidulans VeA subcellular localization is dependent on the
RT importin alpha carrier and on light.";
RL Mol. Microbiol. 63:242-255(2007).
RN [13]
RP INTERACTION WITH FPHA.
RX PubMed=18291652; DOI=10.1016/j.cub.2008.01.061;
RA Purschwitz J., Mueller S., Kastner C., Schoeser M., Haas H., Espeso E.A.,
RA Atoui A., Calvo A.M., Fischer R.;
RT "Functional and physical interaction of blue- and red-light sensors in
RT Aspergillus nidulans.";
RL Curr. Biol. 18:255-259(2008).
RN [14]
RP FUNCTION.
RX PubMed=17977758; DOI=10.1016/j.fgb.2007.09.008;
RA Han K.H., Kim J.H., Moon H., Kim S., Lee S.S., Han D.M., Jahng K.Y.,
RA Chae K.S.;
RT "The Aspergillus nidulans esdC (early sexual development) gene is necessary
RT for sexual development and is controlled by veA and a heterotrimeric G
RT protein.";
RL Fungal Genet. Biol. 45:310-318(2008).
RN [15]
RP IDENTIFICATION IN THE VELVET COMPLEX, FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18556559; DOI=10.1126/science.1155888;
RA Bayram O., Krappmann S., Ni M., Bok J.W., Helmstaedt K., Valerius O.,
RA Braus-Stromeyer S., Kwon N.J., Keller N.P., Yu J.H., Braus G.H.;
RT "VelB/VeA/LaeA complex coordinates light signal with fungal development and
RT secondary metabolism.";
RL Science 320:1504-1506(2008).
RN [16]
RP INDUCTION.
RX PubMed=19479257; DOI=10.1007/s00294-009-0253-y;
RA Kim H.Y., Han K.H., Lee M., Oh M., Kim H.S., Zhixiong X., Han D.M.,
RA Jahng K.Y., Kim J.H., Chae K.S.;
RT "The veA gene is necessary for the negative regulation of the veA
RT expression in Aspergillus nidulans.";
RL Curr. Genet. 55:391-397(2009).
RN [17]
RP SUBCELLULAR LOCATION.
RX PubMed=19318129; DOI=10.1016/j.fgb.2009.03.006;
RA Araujo-Bazan L., Dhingra S., Chu J., Fernandez-Martinez J., Calvo A.M.,
RA Espeso E.A.;
RT "Importin alpha is an essential nuclear import carrier adaptor required for
RT proper sexual and asexual development and secondary metabolism in
RT Aspergillus nidulans.";
RL Fungal Genet. Biol. 46:506-515(2009).
RN [18]
RP INTERACTION WITH FPHA, AND PHOSPHORYLATION.
RX PubMed=18936976; DOI=10.1007/s00438-008-0390-x;
RA Purschwitz J., Mueller S., Fischer R.;
RT "Mapping the interaction sites of Aspergillus nidulans phytochrome FphA
RT with the global regulator VeA and the White Collar protein LreB.";
RL Mol. Genet. Genomics 281:35-42(2009).
RN [19]
RP FUNCTION.
RX PubMed=19210625; DOI=10.1111/j.1365-2958.2009.06606.x;
RA Bayram O., Sari F., Braus G.H., Irniger S.;
RT "The protein kinase ImeB is required for light-mediated inhibition of
RT sexual development and for mycotoxin production in Aspergillus nidulans.";
RL Mol. Microbiol. 71:1278-1295(2009).
RN [20]
RP SUBCELLULAR LOCATION.
RX PubMed=20816830; DOI=10.1016/j.fgb.2010.08.007;
RA Atoui A., Kastner C., Larey C.M., Thokala R., Etxebeste O., Espeso E.A.,
RA Fischer R., Calvo A.M.;
RT "Cross-talk between light and glucose regulation controls toxin production
RT and morphogenesis in Aspergillus nidulans.";
RL Fungal Genet. Biol. 47:962-972(2010).
RN [21]
RP INDUCTION.
RX PubMed=21152013; DOI=10.1371/journal.pgen.1001226;
RA Sarikaya Bayram O., Bayram O., Valerius O., Park H.S., Irniger S.,
RA Gerke J., Ni M., Han K.H., Yu J.H., Braus G.H.;
RT "LaeA control of velvet family regulatory proteins for light-dependent
RT development and fungal cell-type specificity.";
RL PLoS Genet. 6:E1001226-E1001226(2010).
RN [22]
RP IDENTIFICATION IN THE VELVET COMPLEX.
RX PubMed=23065618; DOI=10.1007/978-1-62703-122-6_14;
RA Bayram O., Bayram O.S., Valerius O., Joehnk B., Braus G.H.;
RT "Identification of protein complexes from filamentous fungi with tandem
RT affinity purification.";
RL Methods Mol. Biol. 944:191-205(2012).
RN [23]
RP FUNCTION.
RX PubMed=23841751; DOI=10.1111/mmi.12326;
RA Bok J.W., Soukup A.A., Chadwick E., Chiang Y.M., Wang C.C., Keller N.P.;
RT "VeA and MvlA repression of the cryptic orsellinic acid gene cluster in
RT Aspergillus nidulans involves histone 3 acetylation.";
RL Mol. Microbiol. 89:963-974(2013).
RN [24]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH LLMF.
RX PubMed=23341778; DOI=10.1371/journal.pgen.1003193;
RA Palmer J.M., Theisen J.M., Duran R.M., Grayburn W.S., Calvo A.M.,
RA Keller N.P.;
RT "Secondary metabolism and development is mediated by LlmF control of VeA
RT subcellular localization in Aspergillus nidulans.";
RL PLoS Genet. 9:E1003193-E1003193(2013).
RN [25]
RP PHOSPHORYLATION AT THR-167; THR-170; SER-183 AND TYR-254, MUTAGENESIS OF
RP THR-167; THR-170; SER-183 AND TYR-254, INTERACTION WITH VELB AND PHPA,
RP SUBCELLULAR LOCATION, DOMAIN, AND INDUCTION.
RX PubMed=26564476; DOI=10.1111/mmi.13275;
RA Rauscher S., Pacher S., Hedtke M., Kniemeyer O., Fischer R.;
RT "A phosphorylation code of the Aspergillus nidulans global regulator
RT VelvetA (VeA) determines specific functions.";
RL Mol. Microbiol. 99:909-924(2016).
CC -!- FUNCTION: Component of the velvet transcription factor complex that
CC controls sexual/asexual developmental ratio in response to light,
CC promoting sexual development in the darkness while stimulating asexual
CC sporulation under illumination (PubMed:12223191, PubMed:2253875,
CC PubMed:2076818, PubMed:14665453, PubMed:18556559, PubMed:19210625). The
CC velvet complex acts as a global regulator for secondary metabolite gene
CC expression (PubMed:18556559). Controls the expression of the
CC sterigmatocystin and penicillin gene clusters (PubMed:14665453,
CC PubMed:17375284). Represses the cryptic ors gene cluster producing
CC orsellinic acid and its F9775 derivatives in a laeA-independent manner
CC (PubMed:23841751). Required for full induction of faoA gene expression
CC by fructosyl amines (PubMed:12375102). Positively regulates the
CC expression of the early sexual development gene esdC (PubMed:17977758).
CC Controls the expression of mannoprotein mnpA (PubMed:12620259).
CC {ECO:0000269|PubMed:12223191, ECO:0000269|PubMed:12375102,
CC ECO:0000269|PubMed:12620259, ECO:0000269|PubMed:14665453,
CC ECO:0000269|PubMed:17977758, ECO:0000269|PubMed:18556559,
CC ECO:0000269|PubMed:19210625, ECO:0000269|PubMed:2076818,
CC ECO:0000269|PubMed:2253875, ECO:0000269|PubMed:23841751}.
CC -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC laeA, veA and velB; VeA acting as a bridging protein between laeA and
CC velB (PubMed:18556559). Interacts with the light-sensing phytochrome
CC fphA (PubMed:18291652, PubMed:18936976). Interacts with llmF
CC (PubMed:23341778). {ECO:0000269|PubMed:18291652,
CC ECO:0000269|PubMed:18556559, ECO:0000269|PubMed:18936976,
CC ECO:0000269|PubMed:23341778}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17163983,
CC ECO:0000269|PubMed:18556559, ECO:0000269|PubMed:19318129,
CC ECO:0000269|PubMed:20816830, ECO:0000269|PubMed:23341778}. Cytoplasm
CC {ECO:0000269|PubMed:17163983, ECO:0000269|PubMed:18556559,
CC ECO:0000269|PubMed:19318129, ECO:0000269|PubMed:20816830,
CC ECO:0000269|PubMed:23341778}. Note=Enriched in the nucleus in the dark
CC (PubMed:17163983, PubMed:18556559, PubMed:20816830). Migration to the
CC nucleus depends on the importin alpha carrier protein KapA
CC (PubMed:17163983, PubMed:19318129). Migration to the nucleus is also
CC controled by llmF (PubMed:23341778). {ECO:0000269|PubMed:17163983,
CC ECO:0000269|PubMed:18556559, ECO:0000269|PubMed:19318129,
CC ECO:0000269|PubMed:23341778}.
CC -!- INDUCTION: Expressed almost constitutively at an increased level
CC throughout the asexual and sexual developmental processes
CC (PubMed:12223191). Negatively regulates its own expression
CC (PubMed:19479257). Expression is derepressed in light-illuminated
CC conditions (PubMed:19479257). Expression is regulated by laeA
CC (PubMed:21152013). Regulates its own expression, depending on its
CC phosphorylation state (PubMed:26564476). {ECO:0000269|PubMed:12223191,
CC ECO:0000269|PubMed:19479257, ECO:0000269|PubMed:21152013,
CC ECO:0000269|PubMed:26564476}.
CC -!- DOMAIN: The C-terminal PEST domain is a region rich in proline,
CC glutamic acid, serine and threonine residues that is required for the
CC light-dependent regulation of development and secondary metabolism.
CC {ECO:0000269|PubMed:26564476}.
CC -!- PTM: Phosphorylated at Thr-167, Thr-170, Ser-183 and Tyr-254
CC (PubMed:26564476). Thr-167 should be phosphorylated and T170 and S183
CC should be dephosphorylated to achieve light induction of conidiation
CC (PubMed:26564476). Phosphorylation of Ser-183 and Tyr-254 influence
CC sterigmatocystin production in a light-independent manner
CC (PubMed:26564476). Phosphorylation of Thr-167 and Thr-170 modulates
CC expression of veA (PubMed:26564476). {ECO:0000269|PubMed:18936976,
CC ECO:0000269|PubMed:26564476}.
CC -!- DISRUPTION PHENOTYPE: Aboshes light-dependent conidiation, allowing
CC conidiation to occur in the dark (PubMed:2076818). Impairs formation of
CC sexual structures, even under conditions where sexual development
CC preferentially occurs (PubMed:12223191). Alters the expression of the
CC transcription factors nsdD, steA and brlA, the penicillin biosynthetic
CC genes ipnA and acvA, as well as of the sterigmatocystin-specific
CC regulatory gene aflR (PubMed:14665453). {ECO:0000269|PubMed:12223191,
CC ECO:0000269|PubMed:14665453, ECO:0000269|PubMed:2076818}.
CC -!- SIMILARITY: Belongs to the velvet family. VeA subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CBF88249.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; U95045; AAC26841.1; -; Genomic_DNA.
DR EMBL; AF109316; AAD42946.1; -; mRNA.
DR EMBL; AF335465; AAK21245.1; -; Genomic_DNA.
DR EMBL; BN001308; CBF88249.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; C8VTV4; -.
DR SMR; C8VTV4; -.
DR STRING; 162425.CADANIAP00001588; -.
DR iPTMnet; C8VTV4; -.
DR eggNOG; ENOG502QVY9; Eukaryota.
DR HOGENOM; CLU_022491_2_0_1; -.
DR InParanoid; C8VTV4; -.
DR OrthoDB; 1171722at2759; -.
DR Proteomes; UP000000560; Chromosome VIII.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.3960; -; 1.
DR InterPro; IPR021740; Velvet.
DR InterPro; IPR037525; Velvet_dom.
DR InterPro; IPR038491; Velvet_dom_sf.
DR PANTHER; PTHR33572; PTHR33572; 1.
DR Pfam; PF11754; Velvet; 2.
DR PROSITE; PS51821; VELVET; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Sporulation;
KW Transcription; Transcription regulation.
FT CHAIN 1..573
FT /note="Developmental and secondary metabolism regulator
FT veA"
FT /id="PRO_0000435759"
FT DOMAIN 27..230
FT /note="Velvet"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..498
FT /note="PEST"
FT /evidence="ECO:0000269|PubMed:26564476"
FT MOTIF 41..46
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000305|PubMed:12223191"
FT COMPBIAS 237..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..360
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 167
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:26564476"
FT MOD_RES 170
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:26564476"
FT MOD_RES 183
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:26564476"
FT MOD_RES 254
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000269|PubMed:26564476"
FT MUTAGEN 167
FT /note="T->E: Leads to strong light induction of
FT conidiation."
FT /evidence="ECO:0000269|PubMed:26564476"
FT MUTAGEN 167
FT /note="T->V: Leads to loss of sterigmatocystin production
FT in darkness."
FT /evidence="ECO:0000269|PubMed:26564476"
FT MUTAGEN 170
FT /note="T->E: Leads to an increase of sterigmatocystin
FT production in darkness."
FT /evidence="ECO:0000269|PubMed:26564476"
FT MUTAGEN 170
FT /note="T->V: Leads to strong light induction of
FT conidiation."
FT /evidence="ECO:0000269|PubMed:26564476"
FT MUTAGEN 183
FT /note="S->A: Leads to strong light induction of
FT conidiation."
FT /evidence="ECO:0000269|PubMed:26564476"
FT MUTAGEN 183
FT /note="S->E: Leads to increased production of
FT sterigmatocystin in darkness and after illumination."
FT /evidence="ECO:0000269|PubMed:26564476"
FT MUTAGEN 254
FT /note="Y->E,F: Leads to increased production of
FT sterigmatocystin in darkness and after illumination."
FT /evidence="ECO:0000269|PubMed:26564476"
SQ SEQUENCE 573 AA; 63113 MW; 584C7639C5E8FC1D CRC64;
MATLAAPPPP LGESGNSNSV SRITREGKKI TYKLNIMQQP KRARACGQGS KSHTDRRPVD
PPPVIELNIF ESDPHDDSNK TDITFVYNAN FFLFATLEPE RPIATGKLMT NQGSPVLTGV
PVAGVAYLDK PNRAGYFIFP DLSVRNEGSY RFSFHLFEQI KDPKDATEGT QPMPSPVPGK
LSSPQEFLEF RLEVISNPFI VYSAKKFPGL TTSTPISRMI AEQGCRVRIR RDVRMRRRGD
KRTEDYDYDN ERGYNNRRPD QYAGSDAYAN APERPRSTSI STNMDPYSYP SRRPSAVEYG
QPIAQPYQRP MASTPAPSST PIPAPIPMPG PVALPPSTPS PASAHAPAPP SVPLAAPPPL
HTPSYQSHLS FGATQTQYPA PQLSHIPQQT TTPTHPYSPR SSISHSRNQS ISEYEPSMGY
PGSQTRLSAE RPSYGQPSQT TSLPPLRHSL EPSVNSRSKT PSNMITSLPP IQSLSELPST
TSQPSSAIGS SPANEPGPRL WETNSMLSKR TYEESFGHDD RPLYNGMRPD SESYPGGMQR
RPSYERSSLL DGPDQMAYKR ANGRMVSKPA TMR
