VEA_FUSO4
ID VEA_FUSO4 Reviewed; 532 AA.
AC A0A0D2Y4S0; A0A0J9VJV8;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2015, sequence version 1.
DT 25-MAY-2022, entry version 27.
DE RecName: Full=Developmental and secondary metabolism regulator veA {ECO:0000305};
DE AltName: Full=Velvet complex subunit A {ECO:0000305};
GN Name=veA {ECO:0000303|PubMed:23106229}; ORFNames=FOXG_11273;
OS Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935
OS / NRRL 34936) (Fusarium vascular wilt of tomato).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=426428;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4287 / CBS 123668 / FGSC 9935 / NRRL 34936;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [2]
RP IDENTIFICATION.
RC STRAIN=4287 / CBS 123668 / FGSC 9935 / NRRL 34936;
RG EnsemblFungi;
RL Submitted (MAR-2015) to UniProtKB.
RN [3]
RP IDENTIFICATION IN THE VELVET COMPLEX, FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23106229; DOI=10.1111/mmi.12082;
RA Lopez-Berges M.S., Hera C., Sulyok M., Schaefer K., Capilla J., Guarro J.,
RA Di Pietro A.;
RT "The velvet complex governs mycotoxin production and virulence of Fusarium
RT oxysporum on plant and mammalian hosts.";
RL Mol. Microbiol. 87:49-65(2013).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24240057; DOI=10.1016/j.fgb.2013.11.002;
RA Lopez-Berges M.S., Schaefer K., Hera C., Di Pietro A.;
RT "Combinatorial function of velvet and AreA in transcriptional regulation of
RT nitrate utilization and secondary metabolism.";
RL Fungal Genet. Biol. 62:78-84(2014).
CC -!- FUNCTION: Component of the velvet transcription factor complex that
CC controls sexual/asexual developmental ratio in response to light,
CC promoting sexual development in the darkness while stimulating asexual
CC sporulation under illumination (By similarity). The velvet complex hat
CC acts as a global regulator for secondary metabolite gene expression (By
CC similarity). Controls the biosynthetic gene cluster for beauvericin, a
CC depsipeptide mycotoxin that functions as a virulence determinant
CC (PubMed:23106229). Regulates also chromatin structure and transcription
CC of siderophore biosynthetic genes and is required for infection of
CC tomato plants (PubMed:23106229). Governs expression of nitrate
CC metabolism genes (PubMed:24240057). {ECO:0000250|UniProtKB:C8VTV4,
CC ECO:0000269|PubMed:23106229, ECO:0000269|PubMed:24240057}.
CC -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC laeA, veA and velB; VeA acting as a bridging protein between laeA and
CC velB (PubMed:23106229). {ECO:0000269|PubMed:23106229}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTV4}. Cytoplasm
CC {ECO:0000250|UniProtKB:C8VTV4}. Note=Enriched in the nucleus in the
CC dark (By similarity). {ECO:0000250|UniProtKB:C8VTV4}.
CC -!- DOMAIN: The C-terminal PEST domain is a region rich in proline,
CC glutamic acid, serine and threonine residues that is required for the
CC light-dependent regulation of development and secondary metabolism (By
CC similarity). {ECO:0000250|UniProtKB:C8VTV4}.
CC -!- DISRUPTION PHENOTYPE: Impairs production of beauvericin and attenuates
CC virulence during infection of tomato plants (PubMed:23106229). Impairs
CC also growth on the non-preferred nitrogen sources nitrate and nitrite
CC (PubMed:24240057). {ECO:0000269|PubMed:23106229,
CC ECO:0000269|PubMed:24240057}.
CC -!- SIMILARITY: Belongs to the velvet family. VeA subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=KNB11333.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DS231709; KNB11331.1; -; Genomic_DNA.
DR EMBL; DS231709; KNB11332.1; -; Genomic_DNA.
DR EMBL; DS231709; KNB11333.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_018249376.1; XM_018390838.1.
DR RefSeq; XP_018249377.1; XM_018390839.1.
DR RefSeq; XP_018249378.1; XM_018390840.1.
DR AlphaFoldDB; A0A0D2Y4S0; -.
DR SMR; A0A0D2Y4S0; -.
DR EnsemblFungi; FOXG_11273T0; FOXG_11273P0; FOXG_11273.
DR EnsemblFungi; KNB11331; KNB11331; FOXG_11273.
DR EnsemblFungi; KNB11332; KNB11332; FOXG_11273.
DR EnsemblFungi; KNB11333; KNB11333; FOXG_11273.
DR GeneID; 28952686; -.
DR KEGG; fox:FOXG_11273; -.
DR VEuPathDB; FungiDB:FOXG_11273; -.
DR OMA; NFFLYAT; -.
DR Proteomes; UP000009097; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.3960; -; 1.
DR InterPro; IPR021740; Velvet.
DR InterPro; IPR037525; Velvet_dom.
DR InterPro; IPR038491; Velvet_dom_sf.
DR PANTHER; PTHR33572; PTHR33572; 1.
DR Pfam; PF11754; Velvet; 2.
DR PROSITE; PS51821; VELVET; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..532
FT /note="Developmental and secondary metabolism regulator
FT veA"
FT /id="PRO_0000435771"
FT DOMAIN 26..220
FT /note="Velvet"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT REGION 41..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..462
FT /note="PEST"
FT /evidence="ECO:0000250|UniProtKB:C8VTV4"
FT REGION 448..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 40..45
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:C8VTV4"
FT COMPBIAS 243..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..309
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..464
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 532 AA; 59293 MW; 19378A6FAC7B46EF CRC64;
MATPSSIPAE PKRDVINRIH RVTRENRSLW YQMTVLQQPE RARACGSGSK ANSDRRPVDP
PPVVELRIIE GPSVEEGKDI TFDYNANFFL YASLEHARPL ARGRVNTPAA GNPPILTGVP
ASGMAYLDRP TEAGYFIFPD LSVRHEGLYI LTFSLFETTK EERDYDLEPA DGDLPPGVDY
RMEIKTEPFS VYSAKKFPGL MESTQLSKTV ADQGCRVRIR RDVRMRKRES KPGAGNSNSG
GNGFERREED FSRRRTITPA SEDPHSIRNR SHSNSSEHRT PYTDASRRPS MVDSYPPPPP
PPPPSYEPAP SASRHLDFGD SSAAQYPTPR QYAHQPGLQI TPGPPNGSYA PTAQSPYSKT
DVPYGYVNRN IPPSCPSPAP SLKHELYDRR QSTSTYVPPS PSVYSTEGHH RRDSRPSYPP
TPVAAPHPRP MHSQTSLPAL KIDQLVSPVS PLPPIEPQTG PAPELPPINV GGKRKHESVF
AQSTRPLHNG QRQVDPHYGR SHRGYSPDHD QGWYSRADGQ ISSVQFNRYY DE
