VEA_MAGO7
ID VEA_MAGO7 Reviewed; 594 AA.
AC G4N5X8;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 25-MAY-2022, entry version 38.
DE RecName: Full=Developmental and secondary metabolism regulator veA {ECO:0000305};
DE AltName: Full=Velvet complex subunit A {ECO:0000305};
GN Name=VEA {ECO:0000303|PubMed:24632440}; ORFNames=MGG_08556;
OS Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS fungus) (Pyricularia oryzae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX NCBI_TaxID=242507;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX PubMed=15846337; DOI=10.1038/nature03449;
RA Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL Nature 434:980-986(2005).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24632440; DOI=10.1016/j.fgb.2014.02.011;
RA Kim H.J., Han J.H., Kim K.S., Lee Y.H.;
RT "Comparative functional analysis of the velvet gene family reveals unique
RT roles in fungal development and pathogenicity in Magnaporthe oryzae.";
RL Fungal Genet. Biol. 66:33-43(2014).
CC -!- FUNCTION: Component of the velvet transcription factor complex that
CC controls sexual/asexual developmental ratio in response to light,
CC promoting sexual development in the darkness while stimulating asexual
CC sporulation under illumination (By similarity). The velvet complex acts
CC as a global regulator for secondary metabolite gene expression (By
CC similarity). Regulates of the response to reactive oxygen species (ROS)
CC stress (PubMed:24632440). {ECO:0000250|UniProtKB:C8VTV4,
CC ECO:0000269|PubMed:24632440}.
CC -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC LAEA, VEA and VELB; VEA acting as a bridging protein between LAEA and
CC VELB (By similarity). {ECO:0000250|UniProtKB:C8VTV4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTV4}. Cytoplasm
CC {ECO:0000250|UniProtKB:C8VTV4}. Note=Enriched in the nucleus in the
CC dark (By similarity). {ECO:0000250|UniProtKB:C8VTV4}.
CC -!- DOMAIN: The C-terminal PEST domain is a region rich in proline,
CC glutamic acid, serine and threonine residues that is required for the
CC light-dependent regulation of development and secondary metabolism (By
CC similarity). {ECO:0000250|UniProtKB:C8VTV4}.
CC -!- DISRUPTION PHENOTYPE: Leads to reduced formation of conidia
CC (PubMed:24632440). {ECO:0000269|PubMed:24632440}.
CC -!- SIMILARITY: Belongs to the velvet family. VeA subfamily. {ECO:0000305}.
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DR EMBL; CM001234; EHA49754.1; -; Genomic_DNA.
DR RefSeq; XP_003716073.1; XM_003716025.1.
DR AlphaFoldDB; G4N5X8; -.
DR SMR; G4N5X8; -.
DR STRING; 318829.MGG_08556T0; -.
DR EnsemblFungi; MGG_08556T0; MGG_08556T0; MGG_08556.
DR GeneID; 2678672; -.
DR KEGG; mgr:MGG_08556; -.
DR VEuPathDB; FungiDB:MGG_08556; -.
DR eggNOG; ENOG502QVY9; Eukaryota.
DR HOGENOM; CLU_022491_2_0_1; -.
DR InParanoid; G4N5X8; -.
DR OMA; NHFVTHR; -.
DR OrthoDB; 1116441at2759; -.
DR PHI-base; PHI:4113; -.
DR Proteomes; UP000009058; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.3960; -; 1.
DR InterPro; IPR021740; Velvet.
DR InterPro; IPR037525; Velvet_dom.
DR InterPro; IPR038491; Velvet_dom_sf.
DR PANTHER; PTHR33572; PTHR33572; 1.
DR Pfam; PF11754; Velvet; 2.
DR PROSITE; PS51821; VELVET; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..594
FT /note="Developmental and secondary metabolism regulator
FT veA"
FT /id="PRO_0000435907"
FT DOMAIN 24..220
FT /note="Velvet"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT REGION 40..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..506
FT /note="PEST"
FT /evidence="ECO:0000250|UniProtKB:C8VTV4"
FT MOTIF 38..43
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:C8VTV4"
FT COMPBIAS 248..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..310
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 594 AA; 66832 MW; 79B94CC840184C80 CRC64;
MKASTDHHVS GPPPVMIERV TRGGRRLFYR IDVIQQPEKC RACGSGPKSS TDRRPVDPPP
VVELRIFEGP RFEEAKDITF TYNANFFLFA TLEKARPMAH GRVTGPVVDA PPVLTGMPVS
GMAYLDRPIE AGYFLFPDLS VRHEGTYRLS FNLYEETKDD RDKDMEPDEP SSEPQGFFYH
RMEIKSADFA CFSAKKFPGL GLSTPLSMTM AEQGTRVRIR RDVRMRRRDG KPSSGGGDFS
SNSNNNAEDE AARRRRTRTP EPPAREDLRR SLSGTGDAPA RNPEPQRRPS AADYRAPPPP
NPPPPGFPSA QVPATSHLTF GGAPYGSHSQ YQQPTSSSSS SEQVSSVPQS PAYSSHAAQQ
HYGQAPQPPT PTYPERRLSD HRSSQPNNHP QQSPHQHSYS HRSSPQRERF MPDSRRPSAP
SHSHILSARP MTPQSANELR RPSDYNRPIP PPTDVLVADT QATPHLPPIR WPRPNMNLPS
PPSEHQEALQ PLQPAPLHYE SQTHQQQLGG RKRTHDSYEE HSYSYGYSYS HNHSHGYGPT
PSARPPAKNR KRPEDVEEKY TVTETMVVDR PEQFFPKPLK YVWTQCRAEP PPRE
