ID   VEA_NEUCR               Reviewed;         554 AA.
AC   Q1K5S5;
DT   16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Developmental and secondary metabolism regulator ve-1 {ECO:0000305};
DE   AltName: Full=Velvet complex subunit 1 {ECO:0000305};
GN   Name=ve-1 {ECO:0000303|PubMed:17631397}; ORFNames=NCU01731;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION.
RX   PubMed=17631397; DOI=10.1016/j.fgb.2007.06.001;
RA   Bayram O., Krappmann S., Seiler S., Vogt N., Braus G.H.;
RT   "Neurospora crassa ve-1 affects asexual conidiation.";
RL   Fungal Genet. Biol. 45:127-138(2008).
CC   -!- FUNCTION: Component of the velvet transcription factor complex that
CC       controls sexual/asexual developmental ratio in response to light,
CC       promoting sexual development in the darkness while stimulating asexual
CC       sporulation under illumination (PubMed:17631397). The velvet complex
CC       hat acts as a global regulator for secondary metabolite gene expression
CC       (By similarity). {ECO:0000250|UniProtKB:C8VTV4,
CC       ECO:0000269|PubMed:17631397}.
CC   -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC       lae-1, ve-1 and vel-2; Ve-1 acting as a bridging protein between lae-1
CC       and vel-2 (By similarity). {ECO:0000250|UniProtKB:C8VTV4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTV4}. Cytoplasm
CC       {ECO:0000250|UniProtKB:C8VTV4}. Note=Enriched in the nucleus in the
CC       dark (By similarity). {ECO:0000250|UniProtKB:C8VTV4}.
CC   -!- INDUCTION: Constitutively expressed during asexual and sexual
CC       development and induced by red light, indicating a light-dependent
CC       regulation (PubMed:17631397). {ECO:0000269|PubMed:17631397}.
CC   -!- DOMAIN: The C-terminal PEST domain is a region rich in proline,
CC       glutamic acid, serine and threonine residues that is required for the
CC       light-dependent regulation of development and secondary metabolism (By
CC       similarity). {ECO:0000250|UniProtKB:C8VTV4}.
CC   -!- DISRUPTION PHENOTYPE: Results in increased conidiation associated with
CC       stunted aerial hyphae (PubMed:17631397). {ECO:0000269|PubMed:17631397}.
CC   -!- SIMILARITY: Belongs to the velvet family. VeA subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM002237; EAA27918.1; -; Genomic_DNA.
DR   PIR; T49833; T49833.
DR   RefSeq; XP_957154.1; XM_952061.2.
DR   AlphaFoldDB; Q1K5S5; -.
DR   SMR; Q1K5S5; -.
DR   STRING; 5141.EFNCRP00000001641; -.
DR   EnsemblFungi; EAA27918; EAA27918; NCU01731.
DR   GeneID; 3873347; -.
DR   KEGG; ncr:NCU01731; -.
DR   VEuPathDB; FungiDB:NCU01731; -.
DR   HOGENOM; CLU_022491_2_0_1; -.
DR   InParanoid; Q1K5S5; -.
DR   Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.3960; -; 1.
DR   InterPro; IPR021740; Velvet.
DR   InterPro; IPR037525; Velvet_dom.
DR   InterPro; IPR038491; Velvet_dom_sf.
DR   PANTHER; PTHR33572; PTHR33572; 1.
DR   Pfam; PF11754; Velvet; 2.
DR   PROSITE; PS51821; VELVET; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..554
FT                   /note="Developmental and secondary metabolism regulator ve-
FT                   1"
FT                   /id="PRO_0000435766"
FT   DOMAIN          31..230
FT                   /note="Velvet"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT   REGION          166..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          455..487
FT                   /note="PEST"
FT                   /evidence="ECO:0000250|UniProtKB:C8VTV4"
FT   REGION          465..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           45..50
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:C8VTV4"
FT   COMPBIAS        236..267
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..295
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..351
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        360..374
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..421
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        502..528
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   554 AA;  61588 MW;  C08864F4417896A4 CRC64;
     MGAQVIAAAS NGLCHDDEPI ASVKSRITRS GRKLWYSLRV VQEPLRARAC GSGPKSSADR
     RPVDPPPVVE LRIFEGESFE MAQERDVTFQ YNANFFLYAT LEHARVMAQG RLQTPSANTP
     PVLTGMPVSG MAYLDRPKLA GYFLFPDLSV RHEGRYKLTF NLYEETKEDK DKDPEEPNAP
     PDGSPGSFDF RMDIKSHDFV VYSAKKFPGL TESTPLSRTV AEQGCRVRIR RDVRMRRRDG
     KGNSGGNDYE NGEEEYRRAR RTATPDTAKQ EAYRQRSMSG STERTPYSSI SDPQRRPSMA
     DYPPQYAAQT PTSGGHLGFL GGNTHHQYPA QPPPQSFAQP HSVPPSPVYP TSQRAPYQHQ
     PSSYPPPPPP HQPIFQSEHH TSRTYAPINP ASRHDSIHQS TKQYTLPPLS EAVSPTQPHH
     QHPSIAPHRL PVTALPPLQV DRFSSASHNQ HPMVSPSNMA APPYPRAYSV SNSGGLTSAG
     GYNQLPPPPP PPPQVAGSKR AHDQTFRADP EMRRYQDGAR ERESVDDKEP PLCTFKYRRA
     DGSVECKQAD IGGY