VEA_ZYMTI
ID VEA_ZYMTI Reviewed; 255 AA.
AC F9X365;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 25-MAY-2022, entry version 34.
DE RecName: Full=Developmental and secondary metabolism regulator MVE1 {ECO:0000305};
DE AltName: Full=Velvet complex subunit 1 {ECO:0000305};
DE Flags: Fragment;
GN Name=MVE1 {ECO:0000303|PubMed:21115702}; ORFNames=MYCGRDRAFT_37276;
OS Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch
OS fungus) (Septoria tritici).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Zymoseptoria.
OX NCBI_TaxID=336722;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 115943 / IPO323;
RX PubMed=21695235; DOI=10.1371/journal.pgen.1002070;
RA Goodwin S.B., Ben M'barek S., Dhillon B., Wittenberg A.H.J., Crane C.F.,
RA Hane J.K., Foster A.J., Van der Lee T.A.J., Grimwood J., Aerts A.,
RA Antoniw J., Bailey A., Bluhm B., Bowler J., Bristow J., van der Burgt A.,
RA Canto-Canche B., Churchill A.C.L., Conde-Ferraez L., Cools H.J.,
RA Coutinho P.M., Csukai M., Dehal P., De Wit P., Donzelli B.,
RA van de Geest H.C., van Ham R.C.H.J., Hammond-Kosack K.E., Henrissat B.,
RA Kilian A., Kobayashi A.K., Koopmann E., Kourmpetis Y., Kuzniar A.,
RA Lindquist E., Lombard V., Maliepaard C., Martins N., Mehrabi R.,
RA Nap J.P.H., Ponomarenko A., Rudd J.J., Salamov A., Schmutz J.,
RA Schouten H.J., Shapiro H., Stergiopoulos I., Torriani S.F.F., Tu H.,
RA de Vries R.P., Waalwijk C., Ware S.B., Wiebenga A., Zwiers L.-H.,
RA Oliver R.P., Grigoriev I.V., Kema G.H.J.;
RT "Finished genome of the fungal wheat pathogen Mycosphaerella graminicola
RT reveals dispensome structure, chromosome plasticity, and stealth
RT pathogenesis.";
RL PLoS Genet. 7:E1002070-E1002070(2011).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21115702; DOI=10.1128/aem.01830-10;
RA Choi Y.E., Goodwin S.B.;
RT "MVE1, encoding the velvet gene product homolog in Mycosphaerella
RT graminicola, is associated with aerial mycelium formation, melanin
RT biosynthesis, hyphal swelling, and light signaling.";
RL Appl. Environ. Microbiol. 77:942-953(2011).
CC -!- FUNCTION: Component of the velvet transcription factor complex that
CC controls sexual/asexual developmental ratio in response to light,
CC promoting sexual development in the darkness while stimulating asexual
CC sporulation under illumination (By similarity). The velvet complex hat
CC acts as a global regulator for secondary metabolite gene expression (By
CC similarity). Controls the expression of the melanin gene cluster
CC (PubMed:21115702). Mediates the light-stimulated formation of aerial
CC mycelia (PubMed:21115702). {ECO:0000250|UniProtKB:C8VTV4,
CC ECO:0000269|PubMed:21115702}.
CC -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC LAE1, MVE1 and VEL2; MVE1 acting as a bridging protein between LAE1 and
CC VEL2 (By similarity). {ECO:0000250|UniProtKB:C8VQG9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTV4}. Cytoplasm
CC {ECO:0000250|UniProtKB:C8VTV4}. Note=Enriched in the nucleus in the
CC dark (By similarity). {ECO:0000250|UniProtKB:C8VTV4}.
CC -!- DISRUPTION PHENOTYPE: Impairs melanin biosynthesis (PubMed:21115702).
CC Abolishes the light-stimulated formation of aerial mycelia
CC (PubMed:21115702). Results in abnormal hyphal swelling, increases
CC sensitivity to shaking force and significantly reduces hydrophobicity
CC (PubMed:21115702). {ECO:0000269|PubMed:21115702}.
CC -!- SIMILARITY: Belongs to the velvet family. VeA subfamily. {ECO:0000305}.
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DR EMBL; CM001197; EGP90115.1; -; Genomic_DNA.
DR RefSeq; XP_003855139.1; XM_003855091.1.
DR AlphaFoldDB; F9X365; -.
DR SMR; F9X365; -.
DR EnsemblFungi; Mycgr3T37276; Mycgr3P37276; Mycgr3G37276.
DR GeneID; 13400733; -.
DR KEGG; ztr:MYCGRDRAFT_37276; -.
DR eggNOG; ENOG502S0HV; Eukaryota.
DR HOGENOM; CLU_022491_1_2_1; -.
DR InParanoid; F9X365; -.
DR Proteomes; UP000008062; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.3960; -; 1.
DR InterPro; IPR021740; Velvet.
DR InterPro; IPR037525; Velvet_dom.
DR InterPro; IPR038491; Velvet_dom_sf.
DR PANTHER; PTHR33572; PTHR33572; 1.
DR Pfam; PF11754; Velvet; 2.
DR PROSITE; PS51821; VELVET; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..>255
FT /note="Developmental and secondary metabolism regulator
FT MVE1"
FT /id="PRO_0000435768"
FT DOMAIN 31..226
FT /note="Velvet"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT REGION 163..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 45..50
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:C8VTV4"
FT COMPBIAS 232..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 255
FT /evidence="ECO:0000312|EMBL:EGP90115.1"
SQ SEQUENCE 255 AA; 28933 MW; 928071405F59D984 CRC64;
MDRVSERVER GHYIPVENQT ESSTSRVTVE GRKLTYRMSV LQQPVRARAC GQGAKCKSPS
ADRRPVDPPP IVELKIFEGE DQENDITFTM HANYFLFATL EQARPIANGR VSNERSTPVL
TGTPVAGMVY LDRPTPAGYF IFPDLSVRHE GVYRLSFSLY EDCKSPKDED KTEEGAKSES
DAHVTHRLEV KSEPFNVFSA KKFPGLTEST SLSRMVAEQG CRVRIRRDVR MRKRETKPGG
REWDNYEDET AQARA
