VEGFA_CHICK
ID VEGFA_CHICK Reviewed; 216 AA.
AC P67964; P52582; Q91420;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Vascular endothelial growth factor A;
DE Short=VEGF-A;
DE AltName: Full=Vascular permeability factor;
DE Short=VPF;
DE Flags: Precursor;
GN Name=VEGFA; Synonyms=VEGF;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Heart;
RA Takahashi T.;
RT "Chick embryonic ventricular myocytes VEGF.";
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Growth factor active in angiogenesis, vasculogenesis and
CC endothelial cell growth. Induces endothelial cell proliferation,
CC promotes cell migration, inhibits apoptosis and induces
CC permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and
CC KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity).
CC {ECO:0000250|UniProtKB:P15692}.
CC -!- SUBUNIT: Homodimer; disulfide-linked (By similarity). Also found as
CC heterodimer with PGF (By similarity). {ECO:0000250|UniProtKB:P16612}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000305}.
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DR EMBL; AB011078; BAA24925.1; -; mRNA.
DR RefSeq; NP_001103825.1; NM_001110355.1.
DR RefSeq; NP_990373.1; NM_205042.2.
DR AlphaFoldDB; P67964; -.
DR SMR; P67964; -.
DR STRING; 9031.ENSGALP00000016723; -.
DR PaxDb; P67964; -.
DR PRIDE; P67964; -.
DR GeneID; 395909; -.
DR KEGG; gga:395909; -.
DR CTD; 7422; -.
DR VEuPathDB; HostDB:geneid_395909; -.
DR eggNOG; ENOG502QVI8; Eukaryota.
DR HOGENOM; CLU_042996_2_0_1; -.
DR InParanoid; P67964; -.
DR OrthoDB; 1364454at2759; -.
DR PhylomeDB; P67964; -.
DR PRO; PR:P67964; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0043183; F:vascular endothelial growth factor receptor 1 binding; IBA:GO_Central.
DR GO; GO:0005172; F:vascular endothelial growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0001955; P:blood vessel maturation; ISS:Roslin.
DR GO; GO:0003347; P:epicardial cell to mesenchymal cell transition; TAS:DFLAT.
DR GO; GO:0050930; P:induction of positive chemotaxis; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISS:Roslin.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.
DR GO; GO:0051894; P:positive regulation of focal adhesion assembly; ISS:UniProtKB.
DR GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IBA:GO_Central.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; ISS:UniProtKB.
DR GO; GO:0043117; P:positive regulation of vascular permeability; ISS:Roslin.
DR GO; GO:0001666; P:response to hypoxia; IBA:GO_Central.
DR GO; GO:0002040; P:sprouting angiogenesis; IBA:GO_Central.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IBA:GO_Central.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.160.10; -; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR027928; VEGF_C.
DR InterPro; IPR036841; VEGF_C_sf.
DR Pfam; PF00341; PDGF; 1.
DR Pfam; PF14554; VEGF_C; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR SUPFAM; SSF57593; SSF57593; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 2: Evidence at transcript level;
KW Angiogenesis; Developmental protein; Differentiation; Disulfide bond;
KW Glycoprotein; Growth factor; Heparin-binding; Mitogen; Reference proteome;
KW Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000250"
FT CHAIN 27..216
FT /note="Vascular endothelial growth factor A"
FT /id="PRO_0000023392"
FT REGION 132..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..162
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 52..94
FT /evidence="ECO:0000250"
FT DISULFID 77
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 83..128
FT /evidence="ECO:0000250"
FT DISULFID 86
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 87..130
FT /evidence="ECO:0000250"
SQ SEQUENCE 216 AA; 25203 MW; 82E669C2F6FC6DA7 CRC64;
MNFLLTWIHW GLAALLYLQS AELSKAAPAL GDGERKPNEV IKFLEVYERS FCRTIETLVD
IFQEYPDEVE YIFRPSCVPL MRCAGCCGDE GLECVPVDVY NVTMEIARIK PHQSQHIAHM
SFLQHSKCDC RPKKDVKNKQ EKKSKRGKGK GQKRKRKKGR YKPPSFHCEP CSERRKHLFV
QDPQTCKCSC KFTDSRCKSR QLELNERTCR CEKPRR
