VEGFA_PROFL
ID VEGFA_PROFL Reviewed; 216 AA.
AC P67860; C0K3N7; Q68BI2; Q68BI3; Q68BI4;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Vascular endothelial growth factor A;
DE Short=VEGF-A;
DE AltName: Full=Vascular permeability factor;
DE Short=VPF;
DE Flags: Precursor;
OS Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops.
OX NCBI_TaxID=88087;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS VEGF-122; VEGF-166 AND VEGF-190),
RP INTERACTION WITH FLT1; KDR; HEPARAN SULFATE AND HEPARIN, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Kidney;
RX PubMed=15328352; DOI=10.1074/jbc.m403687200;
RA Takahashi H., Hattori S., Iwamatsu A., Takizawa H., Shibuya M.;
RT "A novel snake venom vascular endothelial growth factor (VEGF)
RT predominantly induces vascular permeability through preferential signaling
RT via VEGF receptor-1.";
RL J. Biol. Chem. 279:46304-46314(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF-190).
RC TISSUE=Venom gland;
RX PubMed=19208624; DOI=10.1074/jbc.m809071200;
RA Yamazaki Y., Matsunaga Y., Tokunaga Y., Obayashi S., Saito M., Morita T.;
RT "Snake venom vascular endothelial growth factors (VEGF-Fs) exclusively vary
RT their structures and functions among species.";
RL J. Biol. Chem. 284:9885-9891(2009).
CC -!- FUNCTION: Growth factor active in angiogenesis, vasculogenesis and
CC endothelial cell growth. Induces endothelial cell proliferation,
CC promotes cell migration, inhibits apoptosis and induces
CC permeabilization of blood vessels. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Also found as heterodimer with
CC PGF (By similarity). Interacts to the FLT1/VEGFR1 and KDR/VEGFR2
CC receptors, heparan sulfate and heparin. {ECO:0000250,
CC ECO:0000269|PubMed:15328352}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=VEGF-190;
CC IsoId=P67860-1; Sequence=Displayed;
CC Name=VEGF-166;
CC IsoId=P67860-2; Sequence=VSP_011751;
CC Name=VEGF-122;
CC IsoId=P67860-3; Sequence=VSP_011752;
CC -!- TISSUE SPECIFICITY: Expressed in venom gland, heart, brain, liver,
CC skeletal muscle and kidney. {ECO:0000269|PubMed:15328352}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB154418; BAD38845.1; -; mRNA.
DR EMBL; AB154419; BAD38846.1; -; mRNA.
DR EMBL; AB154420; BAD38847.1; -; mRNA.
DR EMBL; FJ554641; ACN22044.1; -; Genomic_DNA.
DR AlphaFoldDB; P67860; -.
DR SMR; P67860; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.
DR GO; GO:0051894; P:positive regulation of focal adhesion assembly; ISS:UniProtKB.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; ISS:UniProtKB.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.160.10; -; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR027928; VEGF_C.
DR InterPro; IPR036841; VEGF_C_sf.
DR Pfam; PF00341; PDGF; 1.
DR Pfam; PF14554; VEGF_C; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR SUPFAM; SSF57593; SSF57593; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Angiogenesis; Developmental protein; Differentiation;
KW Disulfide bond; Glycoprotein; Growth factor; Heparin-binding; Mitogen;
KW Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..216
FT /note="Vascular endothelial growth factor A"
FT /id="PRO_0000023396"
FT REGION 140..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..161
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT DISULFID 52..94
FT /evidence="ECO:0000250"
FT DISULFID 77
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 83..128
FT /evidence="ECO:0000250"
FT DISULFID 86
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 87..130
FT /evidence="ECO:0000250"
FT VAR_SEQ 142..166
FT /note="KKSKREKGKGQKRKRKRGRYKPQNF -> N (in isoform VEGF-
FT 166)"
FT /evidence="ECO:0000303|PubMed:15328352"
FT /id="VSP_011751"
FT VAR_SEQ 143..210
FT /note="Missing (in isoform VEGF-122)"
FT /evidence="ECO:0000303|PubMed:15328352"
FT /id="VSP_011752"
SQ SEQUENCE 216 AA; 25511 MW; F2A3D98C503E8191 CRC64;
MNFLLTWIHW GLAALLYFHN AKVLQAAPAQ GDGDRQQSEV IPFMTVYERS VCRPIETMVD
IFQDYPDEVE YILKPPCVAL MRCGGCCNDE ALECVPTELY NVTMEIMKLK PYQSQHIHPM
SFQQHSKCEC RPKKETRIIQ EKKSKREKGK GQKRKRKRGR YKPQNFHCEP CSERRKHLYK
QDPLTCKCSC KFTDSRCKSK QLELNERTCR CEKPRR
