VEGFB_BOVIN
ID VEGFB_BOVIN Reviewed; 207 AA.
AC Q9XS49; Q9GLX2; Q9XS48;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2001, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Vascular endothelial growth factor B;
DE Short=VEGF-B;
DE AltName: Full=VEGF-related factor;
DE Short=VRF;
DE Flags: Precursor;
GN Name=VEGFB; Synonyms=VRF;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Heart;
RA Liu X., Yonekura H., Yamagishi S., Yamamoto Y., Yamamoto H.;
RT "Structure and expression of bovine VEGF family.";
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 38-104.
RC TISSUE=Heart;
RA Mandriota S.J., Pepper M.S.;
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Growth factor for endothelial cells. VEGF-B167 binds heparin
CC and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is
CC regulated by proteolysis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Can also form heterodimer with
CC VEGF (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted but remains
CC associated to cells or to the extracellular matrix unless released by
CC heparin. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Comment=Additional isoforms seem to exist.;
CC Name=VEGF-B186;
CC IsoId=Q9XS49-1; Sequence=Displayed;
CC Name=VEGF-B167;
CC IsoId=Q9XS49-2; Sequence=VSP_004637, VSP_004638;
CC -!- PTM: VEGF-B186 is O-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000305}.
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DR EMBL; AB004274; BAA77686.1; -; mRNA.
DR EMBL; AB004273; BAA77685.1; -; mRNA.
DR EMBL; AF099134; AAG29746.1; -; mRNA.
DR RefSeq; NP_776912.1; NM_174487.2. [Q9XS49-2]
DR AlphaFoldDB; Q9XS49; -.
DR SMR; Q9XS49; -.
DR STRING; 9913.ENSBTAP00000018089; -.
DR PaxDb; Q9XS49; -.
DR PRIDE; Q9XS49; -.
DR Ensembl; ENSBTAT00000018089; ENSBTAP00000018089; ENSBTAG00000047567. [Q9XS49-1]
DR GeneID; 282121; -.
DR KEGG; bta:282121; -.
DR CTD; 7423; -.
DR VEuPathDB; HostDB:ENSBTAG00000047567; -.
DR eggNOG; ENOG502SU5Y; Eukaryota.
DR GeneTree; ENSGT00940000161844; -.
DR HOGENOM; CLU_1331530_0_0_1; -.
DR InParanoid; Q9XS49; -.
DR OMA; PRCTQRH; -.
DR OrthoDB; 1364454at2759; -.
DR Proteomes; UP000009136; Chromosome 29.
DR Bgee; ENSBTAG00000047567; Expressed in laryngeal cartilage and 104 other tissues.
DR ExpressionAtlas; Q9XS49; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0043183; F:vascular endothelial growth factor receptor 1 binding; IBA:GO_Central.
DR GO; GO:0005172; F:vascular endothelial growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0060048; P:cardiac muscle contraction; IEA:Ensembl.
DR GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
DR GO; GO:0050930; P:induction of positive chemotaxis; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IBA:GO_Central.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IBA:GO_Central.
DR GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0006493; P:protein O-linked glycosylation; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IBA:GO_Central.
DR GO; GO:0002040; P:sprouting angiogenesis; IBA:GO_Central.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IBA:GO_Central.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Growth factor;
KW Heparin-binding; Mitogen; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..207
FT /note="Vascular endothelial growth factor B"
FT /id="PRO_0000023397"
FT REGION 124..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..175
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 47..89
FT /evidence="ECO:0000250"
FT DISULFID 72
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 78..122
FT /evidence="ECO:0000250"
FT DISULFID 81
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 82..124
FT /evidence="ECO:0000250"
FT VAR_SEQ 137..188
FT /note="RASTPHHRPQPRSVPGWDPAPGAPSPADITHPTPAPGPSAHAAPSAASALTP
FT -> SPRPLCPRCPQRRQRPDPRTCHCRCRRRSFLRCQGRGLELNPDTCRCRKLRR (in
FT isoform VEGF-B167)"
FT /evidence="ECO:0000305"
FT /id="VSP_004637"
FT VAR_SEQ 189..207
FT /note="Missing (in isoform VEGF-B167)"
FT /evidence="ECO:0000305"
FT /id="VSP_004638"
SQ SEQUENCE 207 AA; 21655 MW; 646C82DA1BE17782 CRC64;
MSPLLRRLLL AVLLQLAPAQ APVSQPDAPG HQKKVVSWID VYARATCQPR EVVVPLNMEL
MGTVAKQLVP SCVTVQRCGG CCPDDGLECV PTGQHQVRMQ ILMIQYPSSQ LGEMSLEEHS
QCECRPKKRE SAVKPDRAST PHHRPQPRSV PGWDPAPGAP SPADITHPTP APGPSAHAAP
SAASALTPGP ATAAADAAAS SVVKGGA
