ID   VEGFH_ORFN7             Reviewed;         148 AA.
AC   P52585;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   02-DEC-2020, entry version 69.
DE   RecName: Full=Vascular endothelial growth factor homolog;
DE   Flags: Precursor;
GN   ORFNames=A2R;
OS   Orf virus (strain NZ7) (OV NZ-7).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Parapoxvirus.
OX   NCBI_TaxID=73495;
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8254780; DOI=10.1128/jvi.68.1.84-92.1994;
RA   Lyttle D.J., Fraser K.M., Fleming S.B., Mercer A.A., Robinson A.J.;
RT   "Homologs of vascular endothelial growth factor are encoded by the poxvirus
RT   orf virus.";
RL   J. Virol. 68:84-92(1994).
CC   -!- FUNCTION: Induces endothelial proliferation.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC       {ECO:0000305}.
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DR   EMBL; S67522; AAB29223.1; -; Genomic_DNA.
DR   PIR; D49530; D49530.
DR   SMR; P52585; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   CDD; cd00135; PDGF; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR023581; PD_growth_factor_CS.
DR   InterPro; IPR000072; PDGF/VEGF_dom.
DR   Pfam; PF00341; PDGF; 1.
DR   SMART; SM00141; PDGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00249; PDGF_1; 1.
DR   PROSITE; PS50278; PDGF_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Growth factor; Mitogen; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..148
FT                   /note="Vascular endothelial growth factor homolog"
FT                   /id="PRO_0000023418"
FT   CARBOHYD        95
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        46..88
FT                   /evidence="ECO:0000250"
FT   DISULFID        71
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        77..130
FT                   /evidence="ECO:0000250"
FT   DISULFID        80
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        81..132
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   148 AA;  16078 MW;  F0E13BA104CC73F8 CRC64;
     MKLTATLQVV VALLICMYNL PECVSQSNDS PPSTNDWMRT LDKSGCKPRD TVVYLGEEYP
     ESTNLQYNPR CVTVKRCSGC CNGDGQICTA VETRNTTVTV SVTGVSSSSG TNSGVSTNLQ
     RISVTEHTKC DCIGRTTTTP TTTREPRR