ID   VEGP1_RAT               Reviewed;         177 AA.
AC   P20289;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=von Ebner gland protein 1;
DE            Short=VEG protein 1;
DE   Flags: Precursor;
GN   Name=Vegp1; Synonyms=Vegp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Lingual salivary gland;
RX   PubMed=1689010; DOI=10.1038/343366a0;
RA   Schmale H., Holtgreve-Grez H., Christiansen H.;
RT   "Possible role for salivary gland protein in taste reception indicated by
RT   homology to lipophilic-ligand carrier proteins.";
RL   Nature 343:366-369(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Wistar; TISSUE=Lingual salivary gland;
RX   PubMed=7514123; DOI=10.1111/j.1432-1033.1994.tb18806.x;
RA   Kock K., Ahlers C., Schmale H.;
RT   "Structural organization of the genes for rat von Ebner's gland proteins 1
RT   and 2 reveals their close relationship to lipocalins.";
RL   Eur. J. Biochem. 221:905-916(1994).
CC   -!- FUNCTION: Could play a role in taste reception. Could be necessary for
CC       the concentration and delivery of sapid molecules in the gustatory
CC       system.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; X52016; CAA36263.1; -; mRNA.
DR   EMBL; X74805; CAA52809.1; -; Genomic_DNA.
DR   PIR; S08161; S08161.
DR   RefSeq; NP_075234.1; NM_022945.1.
DR   AlphaFoldDB; P20289; -.
DR   SMR; P20289; -.
DR   STRING; 10116.ENSRNOP00000041023; -.
DR   iPTMnet; P20289; -.
DR   PhosphoSitePlus; P20289; -.
DR   PaxDb; P20289; -.
DR   Ensembl; ENSRNOT00000041399; ENSRNOP00000043245; ENSRNOG00000033020.
DR   GeneID; 65039; -.
DR   KEGG; rno:65039; -.
DR   UCSC; RGD:619872; rat.
DR   CTD; 3933; -.
DR   RGD; 619872; Vegp1.
DR   VEuPathDB; HostDB:ENSRNOG00000033761; -.
DR   eggNOG; ENOG502S22P; Eukaryota.
DR   HOGENOM; CLU_125034_0_0_1; -.
DR   InParanoid; P20289; -.
DR   OMA; TMLISGW; -.
DR   OrthoDB; 1450978at2759; -.
DR   PhylomeDB; P20289; -.
DR   TreeFam; TF338197; -.
DR   Reactome; R-RNO-804914; Transport of fatty acids.
DR   PRO; PR:P20289; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000033761; Expressed in testis and 4 other tissues.
DR   Genevisible; P20289; RN.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0031404; F:chloride ion binding; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0043621; F:protein self-association; ISO:RGD.
DR   GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; ISO:RGD.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002450; von_Ebner_gland.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01175; VNEBNERGLAND.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Secreted; Sensory transduction; Signal;
KW   Taste; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..177
FT                   /note="von Ebner gland protein 1"
FT                   /id="PRO_0000017976"
FT   DISULFID        80..172
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   177 AA;  19726 MW;  CCA36A7F544D6707 CRC64;
     MKALLLTFGL SLLAALQAQA FPTTEENQDV SGTWYLKAAA WDKEIPDKKF GSVSVTPMKI
     KTLEGGNLQV KFTVLIAGRC KEMSTVLEKT DEPAKYTAYS GKQVLYIIPS SVEDHYIFYY
     EGKIHRHHFQ IAKLVGRDPE INQEALEDFQ SVVRAGGLNP DNIFIPKQSE TCPLGSN