VEG_BACSU
ID VEG_BACSU Reviewed; 86 AA.
AC P37466;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Protein Veg;
GN Name=veg; OrderedLocusNames=BSU00440;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=7584024; DOI=10.1093/dnares/1.1.1;
RA Ogasawara N., Nakai S., Yoshikawa H.;
RT "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis
RT chromosome containing the replication origin.";
RL DNA Res. 1:1-14(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26.
RX PubMed=6181373; DOI=10.1007/bf00729452;
RA Moran C.P. Jr., Lang N., LeGrice S.F.J., Lee G., Stephens M.,
RA Sonenshein A.L., Pero J., Losick R.;
RT "Nucleotide sequences that signal the initiation of transcription and
RT translation in Bacillus subtilis.";
RL Mol. Gen. Genet. 186:339-346(1982).
RN [4]
RP INDUCTION.
RX PubMed=6790516; DOI=10.1128/jb.147.2.443-451.1981;
RA Ollington J.F., Losick R.;
RT "A cloned gene that is turned on at an intermediate stage of spore
RT formation in Bacillus subtilis.";
RL J. Bacteriol. 147:443-451(1981).
RN [5]
RP SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=168;
RX PubMed=12761295; DOI=10.1093/jb/mvg062;
RA Fukushima T., Ishikawa S., Yamamoto H., Ogasawara N., Sekiguchi J.;
RT "Transcriptional, functional and cytochemical analyses of the veg gene in
RT Bacillus subtilis.";
RL J. Biochem. 133:475-483(2003).
RN [6]
RP FUNCTION IN BIOFILM FORMATION, AND DISRUPTION PHENOTYPE.
RC STRAIN=168;
RX PubMed=23378512; DOI=10.1128/jb.02201-12;
RA Lei Y., Oshima T., Ogasawara N., Ishikawa S.;
RT "Functional analysis of the protein Veg, which stimulates biofilm formation
RT in Bacillus subtilis.";
RL J. Bacteriol. 195:1697-1705(2013).
CC -!- FUNCTION: Stimulates biofilm formation via transcriptional activation
CC of extracellular matrix genes. Acts by repressing SinR activity,
CC independently of the SinI, SlrA and SlrR pathways. Could also be
CC involved in the regulation of other genes during biofilm and spore
CC formation. {ECO:0000269|PubMed:23378512}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12761295}. Spore
CC core {ECO:0000269|PubMed:12761295}. Note=During sporulation,
CC accumulates in the forespore compartment but not in the mother cell.
CC -!- INDUCTION: Expressed during both vegetative growth phase and
CC sporulation. {ECO:0000269|PubMed:12761295, ECO:0000269|PubMed:6790516}.
CC -!- DISRUPTION PHENOTYPE: Mutants show poor germination in the presence of
CC L-alanine and reduced biofilm formation. {ECO:0000269|PubMed:12761295,
CC ECO:0000269|PubMed:23378512}.
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DR EMBL; D26185; BAA05279.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB11820.1; -; Genomic_DNA.
DR EMBL; J01552; AAA22880.1; -; Genomic_DNA.
DR PIR; S66073; S66073.
DR RefSeq; NP_387925.1; NC_000964.3.
DR RefSeq; WP_003218330.1; NZ_JNCM01000028.1.
DR AlphaFoldDB; P37466; -.
DR SMR; P37466; -.
DR STRING; 224308.BSU00440; -.
DR PaxDb; P37466; -.
DR PRIDE; P37466; -.
DR EnsemblBacteria; CAB11820; CAB11820; BSU_00440.
DR GeneID; 64301865; -.
DR GeneID; 66327952; -.
DR GeneID; 936744; -.
DR KEGG; bsu:BSU00440; -.
DR PATRIC; fig|224308.179.peg.44; -.
DR eggNOG; COG4466; Bacteria.
DR OMA; NIFVVKF; -.
DR PhylomeDB; P37466; -.
DR BioCyc; BSUB:BSU00440-MON; -.
DR PRO; PR:P37466; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR InterPro; IPR009366; Protein_Veg.
DR PANTHER; PTHR40026; PTHR40026; 1.
DR Pfam; PF06257; VEG; 1.
DR PIRSF; PIRSF037257; DUF1021; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome; Sporulation.
FT CHAIN 1..86
FT /note="Protein Veg"
FT /id="PRO_0000065778"
SQ SEQUENCE 86 AA; 9550 MW; 4C9C650ECE7A6015 CRC64;
MAKTLSDIKR SLDGNLGKRL TLKANGGRRK TIERSGILAE TYPSVFVIQL DQDENSFERV
SYSYADILTE TVELTFNDDA ASSVAF
