VELB_COPC7
ID VELB_COPC7 Reviewed; 361 AA.
AC A8NYG2;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 25-MAY-2022, entry version 41.
DE RecName: Full=Velvet complex subunit B {ECO:0000305};
GN Name=velB {ECO:0000303|PubMed:24942908}; ORFNames=CC1G_01332;
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003;
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canbaeck B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kuees U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
RN [2]
RP INDUCTION.
RX PubMed=24942908; DOI=10.1186/1471-2164-15-492;
RA Plaza D.F., Lin C.W., van der Velden N.S., Aebi M., Kuenzler M.;
RT "Comparative transcriptomics of the model mushroom Coprinopsis cinerea
RT reveals tissue-specific armories and a conserved circuitry for sexual
RT development.";
RL BMC Genomics 15:492-492(2014).
CC -!- FUNCTION: Component of the velvet transcription factor complex that
CC controls sexual/asexual developmental ratio in response to light,
CC promoting sexual development in the darkness while stimulating asexual
CC sporulation under illumination (By similarity). The velvet complex acts
CC as a global regulator for secondary metabolite gene expression (By
CC similarity). Component of the velB-VosA heterodimeric complex that
CC plays a dual role in activating genes associated with spore maturation
CC and repressing certain development-associated genes (By similarity).
CC The velB-VosA complex binds DNA through the DNA-binding domain of vosA
CC that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3'
CC consisting of two motifs in the promoters of key developmental
CC regulatory genes (By similarity). {ECO:0000250|UniProtKB:C8VTS4}.
CC -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC laeA, veA and velB; VeA acting as a bridging protein between laeA and
CC velB (By similarity). Forms a heterodimeric complex with vosA; the
CC formation of the velB-vosA complex is light-dependent (By similarity).
CC {ECO:0000250|UniProtKB:C8VTS4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTS4}. Cytoplasm
CC {ECO:0000250|UniProtKB:C8VTS4}. Note=Nuclear localization is mediated
CC by veA (By similarity). {ECO:0000250|UniProtKB:C8VTS4}.
CC -!- INDUCTION: Expression is down-regulated during fruiting body formation
CC (PubMed:24942908). {ECO:0000269|PubMed:24942908}.
CC -!- SIMILARITY: Belongs to the velvet family. VelB subfamily.
CC {ECO:0000305}.
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DR EMBL; AACS02000005; EAU84336.1; -; Genomic_DNA.
DR RefSeq; XP_001837420.1; XM_001837368.1.
DR AlphaFoldDB; A8NYG2; -.
DR SMR; A8NYG2; -.
DR STRING; 5346.XP_001837420.1; -.
DR EnsemblFungi; EAU84336; EAU84336; CC1G_01332.
DR GeneID; 6013976; -.
DR KEGG; cci:CC1G_01332; -.
DR VEuPathDB; FungiDB:CC1G_01332; -.
DR eggNOG; ENOG502S1B4; Eukaryota.
DR InParanoid; A8NYG2; -.
DR OMA; MIQKTNA; -.
DR OrthoDB; 1407766at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.3960; -; 1.
DR InterPro; IPR021740; Velvet.
DR InterPro; IPR037525; Velvet_dom.
DR InterPro; IPR038491; Velvet_dom_sf.
DR PANTHER; PTHR33572; PTHR33572; 1.
DR Pfam; PF11754; Velvet; 1.
DR PROSITE; PS51821; VELVET; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..361
FT /note="Velvet complex subunit B"
FT /id="PRO_0000435911"
FT DOMAIN 1..336
FT /note="Velvet"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT REGION 42..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..148
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 361 AA; 39527 MW; 3B0B9406A94C5D24 CRC64;
MIVRTEDQKL VDVDDVDCSF FLVTVDLWSA DGKQEMNLVL HPSSTDKYAP PNPPTKPSAS
TTRRRTISSS SRPPGHQASN SSTPAPPRPD EQPPSSNGSG YYPSQSQDNL TPSSPYPPHS
NSEQPQTWGY PPPPPIDRAA PFPPPVLPSI QSFNRTASGD WNPSNNDDNY PIDPALRNPE
GYTNNAQPDQ PTYGSGTTYP PNYQTPPMPP NSGNATPQNN IPRNLATYTR TLVGPLSANA
CRLLDEHRKP GIFFLFQDLS VRTEGTFRLR MRLMNVGAPP APEPGSCRVH NDISPILAQT
FTEPFIVYSA KRFPGVPDTT ALSIAFGNQG QKLPLRNRHG TGSKRRRRNQ SGSEGESEDD
S
