VELB_GIBZE
ID VELB_GIBZE Reviewed; 461 AA.
AC I1RCN9; A0A098D3H3; A0A0E0RQF8;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 07-SEP-2016, sequence version 2.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=Velvet complex subunit B {ECO:0000305};
GN Name=velB {ECO:0000303|PubMed:22713714}; ORFNames=FGRRES_15845, FGSG_01362;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22713714; DOI=10.1016/j.fgb.2012.06.005;
RA Jiang J., Yun Y., Liu Y., Ma Z.;
RT "FgVELB is associated with vegetative differentiation, secondary metabolism
RT and virulence in Fusarium graminearum.";
RL Fungal Genet. Biol. 49:653-662(2012).
CC -!- FUNCTION: Component of the velvet transcription factor complex that
CC controls sexual/asexual developmental ratio in response to light,
CC promoting sexual development in the darkness while stimulating asexual
CC sporulation under illumination (By similarity). The velvet complex acts
CC as a global regulator for secondary metabolite gene expression (By
CC similarity). Component of the velB-VosA heterodimeric complex that
CC plays a dual role in activating genes associated with spore maturation
CC and repressing certain development-associated genes (By similarity).
CC The complex binds DNA through the DNA-binding domain of vosA that
CC recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3'
CC consisting of two motifs in the promoters of key developmental
CC regulatory genes (By similarity). Controls the expression of the pink
CC pigment aurofusarin and the mycotoxin deoxynivalenol gene clusters
CC (PubMed:22713714). Regulates hyphae formation, hyphal hydrophobicity
CC and conidiation (PubMed:22713714). Regulates of cell wall integrity and
CC pathogenicity (PubMed:22713714). {ECO:0000250|UniProtKB:C8VTS4,
CC ECO:0000269|PubMed:22713714}.
CC -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC laeA, veA and velB; VeA acting as a bridging protein between laeA and
CC velB (By similarity). Forms a heterodimeric complex with vosA; the
CC formation of the velB-vosA complex is light-dependent (By similarity).
CC {ECO:0000250|UniProtKB:C8VTS4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTS4}. Cytoplasm
CC {ECO:0000250|UniProtKB:C8VTS4}. Note=Nuclear localization is mediated
CC by veA (By similarity). {ECO:0000250|UniProtKB:C8VTS4}.
CC -!- DISRUPTION PHENOTYPE: Exhibits reduced pink pigment formation, but
CC increased yellow pigment production (PubMed:22713714). Down-regulates
CC the six genes involved in biosynthesis of the pink pigment aurofusarin
CC (PubMed:22713714). Down-regulates also the genes involved in the
CC mycotoxin deoxynivalenol biosynthesis (PubMed:22713714). Suppresses of
CC aerial hyphae formation, reduces hyphal hydrophobicity and highly
CC increases conidiation (PubMed:22713714). Impaired virulence on
CC flowering wheat head (PubMed:22713714). {ECO:0000269|PubMed:22713714}.
CC -!- SIMILARITY: Belongs to the velvet family. VelB subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ESU06669.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS231663; ESU06669.1; ALT_SEQ; Genomic_DNA.
DR EMBL; HG970332; CEF73483.1; -; Genomic_DNA.
DR RefSeq; XP_011317154.1; XM_011318852.1.
DR AlphaFoldDB; I1RCN9; -.
DR SMR; I1RCN9; -.
DR STRING; 5518.FGSG_01362P0; -.
DR EnsemblFungi; ESU06669; ESU06669; FGSG_01362.
DR GeneID; 23548805; -.
DR KEGG; fgr:FGSG_01362; -.
DR eggNOG; ENOG502S1B4; Eukaryota.
DR HOGENOM; CLU_149542_0_0_1; -.
DR InParanoid; I1RCN9; -.
DR PHI-base; PHI:2427; -.
DR Proteomes; UP000070720; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.3960; -; 1.
DR InterPro; IPR021740; Velvet.
DR InterPro; IPR037525; Velvet_dom.
DR InterPro; IPR038491; Velvet_dom_sf.
DR PANTHER; PTHR33572; PTHR33572; 1.
DR Pfam; PF11754; Velvet; 1.
DR PROSITE; PS51821; VELVET; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..461
FT /note="Velvet complex subunit B"
FT /id="PRO_0000435783"
FT DOMAIN 138..443
FT /note="Velvet"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT REGION 1..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..58
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..118
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 50519 MW; 0C5C92DA80B6CE61 CRC64;
MSQRMPGPGY SSSVPPPIHA YQQQQQHQHP PPSLLPPPPT QHHHSSHAPP PPPPPSSSSH
SLSSHQHHAP PPPHHHSQLP PYPPTQYQQP HPNQYPRPHP LPPSRNDEPP PPSSEPSPSD
QHEKPKYEPP SVSKIEEGTG LKYSLDVQQQ PIRARMCGFG DKDRRPITPP PCVRLVIINS
ETGKEVDYNT LDHAMFVLSV DLWDKDGIKE VNLVRSSTGP GSGASSNNYS YSTLEPSTPS
YQQQALPPSR ESGYPQGQGL GYAQEYPPSV QQGYGQAPSY QSSSSYGPPQ QYFPRHSGYN
TDPPASSANP LFRNGYGQDQ NALTRMAVVG TQPQGMFTRN LIGSLAASAF RLNDTDKKAG
IWFVLQDLSV RTEGTFRLRF SFVNVGGAGG GLPIHVNQGR APILASCYSQ DFSVYSAKKF
PGVCESTPLS KTFALQGIKI PIRKDTNIKG EGDEEMMYDQ N
