ID   VELB_HYPJQ              Reviewed;         490 AA.
AC   G0RS98;
DT   16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-MAR-2016, sequence version 2.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Velvet complex subunit 2 {ECO:0000305};
GN   Name=VEL2 {ECO:0000303|PubMed:26481618}; ORFNames=TRIREDRAFT_40551;
OS   Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=431241;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=QM6a;
RX   PubMed=18454138; DOI=10.1038/nbt1403;
RA   Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA   Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA   Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA   Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA   Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA   Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA   Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA   Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT   "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT   reesei (syn. Hypocrea jecorina).";
RL   Nat. Biotechnol. 26:553-560(2008).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=26481618; DOI=10.1007/s00253-015-7059-2;
RA   Liu K., Dong Y., Wang F., Jiang B., Wang M., Fang X.;
RT   "Regulation of cellulase expression, sporulation, and morphogenesis by
RT   velvet family proteins in Trichoderma reesei.";
RL   Appl. Microbiol. Biotechnol. 100:769-779(2016).
CC   -!- FUNCTION: Component of the velvet transcription factor complex that
CC       controls sexual/asexual developmental ratio in response to light,
CC       promoting sexual development in the darkness while stimulating asexual
CC       sporulation under illumination (By similarity). The velvet complex acts
CC       as a global regulator for secondary metabolite gene expression (By
CC       similarity). Component of the VEL2-VOS1 heterodimeric complex that
CC       plays a dual role in activating genes associated with spore maturation
CC       and repressing certain development-associated genes (By similarity).
CC       The VEL2-VOS1 complex binds DNA through the DNA-binding domain of VOS1
CC       that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3'
CC       consisting of two motifs in the promoters of key developmental
CC       regulatory genes (By similarity). Regulates expression of cellulase-
CC       encoding genes such as the cellobiohydrolase-encoding genes cbh1 and
CC       cbh2, the endo-beta-1,4-glucanase-encoding genes egl1 and egl2, and the
CC       beta-glucosidase-encoding gene bgl1 (PubMed:26481618).
CC       {ECO:0000250|UniProtKB:C8VTS4, ECO:0000269|PubMed:26481618}.
CC   -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC       LAE1, VEL1 and VEL2; VEL1 acting as a bridging protein between LAE1 and
CC       VEL2 (By similarity). Forms a heterodimeric complex with VOS1; the
CC       formation of the VEL2-VOS1 complex is light-dependent (By similarity).
CC       {ECO:0000250|UniProtKB:C8VTS4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTS4}. Cytoplasm
CC       {ECO:0000250|UniProtKB:C8VTS4}. Note=Nuclear localization is mediated
CC       by VEL1 (By similarity). {ECO:0000250|UniProtKB:C8VTS4}.
CC   -!- DISRUPTION PHENOTYPE: Leads to a significantly hampered growth when
CC       cellulose is used as the sole carbon source (PubMed:26481618).
CC       Decreases strongly sporulation and down-regulates of cellulase-coding
CC       genes (PubMed:26481618). {ECO:0000269|PubMed:26481618}.
CC   -!- SIMILARITY: Belongs to the velvet family. VelB subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EGR45802.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; GL985076; EGR45802.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_006968133.1; XM_006968071.1.
DR   AlphaFoldDB; G0RS98; -.
DR   SMR; G0RS98; -.
DR   STRING; 51453.EGR45802; -.
DR   EnsemblFungi; EGR45802; EGR45802; TRIREDRAFT_40551.
DR   GeneID; 18484792; -.
DR   KEGG; tre:TRIREDRAFT_40551; -.
DR   VEuPathDB; FungiDB:TRIREDRAFT_40551; -.
DR   eggNOG; ENOG502S1B4; Eukaryota.
DR   HOGENOM; CLU_022491_0_0_1; -.
DR   Proteomes; UP000008984; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.3960; -; 2.
DR   InterPro; IPR021740; Velvet.
DR   InterPro; IPR037525; Velvet_dom.
DR   InterPro; IPR038491; Velvet_dom_sf.
DR   PANTHER; PTHR33572; PTHR33572; 1.
DR   Pfam; PF11754; Velvet; 1.
DR   PROSITE; PS51821; VELVET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..490
FT                   /note="Velvet complex subunit 2"
FT                   /id="PRO_0000435785"
FT   DOMAIN          164..474
FT                   /note="Velvet"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT   REGION          23..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          295..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..56
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   490 AA;  53139 MW;  87CAF1815DF08401 CRC64;
     MPSLIPPIVS ASSASNSAAL DHLYHHQPPP RLPLGAVPQS PIQSQAPPPP HLHPPSHHFQ
     LHPGHGHHQQ PHHERDHRLP PPVASYSAHS HHLQHDPLPQ RLESSQPGHP GAAEHRDHPQ
     HALDEPSRSH DPYPSMATGA LVHSESQQPA SASLLLPISN VEEATGRRYH LDVVQQPRRA
     RMCGFGDKDR RPITPPPCVR LIIIDVATGK EIDCNDIDHS MFVLNVDLWN EDGTREVNLV
     RSSTSSSPSV SSTVTYPYGS ISVGESSHTY GQSAHPPSRE APYSVSQTAS YAPEYQTQPT
     YSQGSSAYPS NGTYGPPQQY FPQHQAYRTE TGPPGAMQTT VGGFRGYAQD QNALTKMAVV
     GGQPQGMFTR NLIGSLAASA FRLADTSEHL GIWFVLQDLS VRTEGPFRLR FSFVNVGPLA
     GQNGAKVNTG RAPILASCFS EVFNVYSAKK FPGVCESTPL SKTFAAQGIK IPIRKDANLK
     GGDGEDDYGD