ID   VELB_LACBS              Reviewed;         485 AA.
AC   B0CXQ2;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Velvet complex subunit B {ECO:0000305};
GN   Name=velB {ECO:0000303|PubMed:24942908}; ORFNames=LACBIDRAFT_292785;
OS   Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver)
OS   (Laccaria laccata var. bicolor).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Tricholomataceae; Laccaria.
OX   NCBI_TaxID=486041;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 / ATCC MYA-4686;
RX   PubMed=18322534; DOI=10.1038/nature06556;
RA   Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F.,
RA   Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J.,
RA   Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D.,
RA   Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A.,
RA   DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P.,
RA   Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P.,
RA   Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R.,
RA   Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H.,
RA   Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M.,
RA   Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U.,
RA   Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J.,
RA   Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A.,
RA   Tuskan G., Grigoriev I.V.;
RT   "The genome of Laccaria bicolor provides insights into mycorrhizal
RT   symbiosis.";
RL   Nature 452:88-92(2008).
RN   [2]
RP   INDUCTION.
RX   PubMed=24942908; DOI=10.1186/1471-2164-15-492;
RA   Plaza D.F., Lin C.W., van der Velden N.S., Aebi M., Kuenzler M.;
RT   "Comparative transcriptomics of the model mushroom Coprinopsis cinerea
RT   reveals tissue-specific armories and a conserved circuitry for sexual
RT   development.";
RL   BMC Genomics 15:492-492(2014).
CC   -!- FUNCTION: Component of the velvet transcription factor complex that
CC       controls sexual/asexual developmental ratio in response to light,
CC       promoting sexual development in the darkness while stimulating asexual
CC       sporulation under illumination (By similarity). The velvet complex acts
CC       as a global regulator for secondary metabolite gene expression (By
CC       similarity). Component of the velB-VosA heterodimeric complex that
CC       plays a dual role in activating genes associated with spore maturation
CC       and repressing certain development-associated genes (By similarity).
CC       The velB-VosA complex binds DNA through the DNA-binding domain of vosA
CC       that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3'
CC       consisting of two motifs in the promoters of key developmental
CC       regulatory genes (By similarity). {ECO:0000250|UniProtKB:C8VTS4}.
CC   -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC       laeA, veA and velB; VeA acting as a bridging protein between laeA and
CC       velB (By similarity). Forms a heterodimeric complex with vosA; the
CC       formation of the velB-vosA complex is light-dependent (By similarity).
CC       {ECO:0000250|UniProtKB:C8VTS4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTS4}. Cytoplasm
CC       {ECO:0000250|UniProtKB:C8VTS4}. Note=Nuclear localization is mediated
CC       by veA (By similarity). {ECO:0000250|UniProtKB:C8VTS4}.
CC   -!- INDUCTION: Expression is down-regulated during fruiting body formation
CC       (PubMed:24942908). {ECO:0000269|PubMed:24942908}.
CC   -!- SIMILARITY: Belongs to the velvet family. VelB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DS547094; EDR12301.1; -; Genomic_DNA.
DR   RefSeq; XP_001876565.1; XM_001876530.1.
DR   AlphaFoldDB; B0CXQ2; -.
DR   SMR; B0CXQ2; -.
DR   STRING; 486041.B0CXQ2; -.
DR   EnsemblFungi; EDR12301; EDR12301; LACBIDRAFT_292785.
DR   GeneID; 6072863; -.
DR   KEGG; lbc:LACBIDRAFT_292785; -.
DR   HOGENOM; CLU_022491_4_0_1; -.
DR   InParanoid; B0CXQ2; -.
DR   OrthoDB; 1407766at2759; -.
DR   Proteomes; UP000001194; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.3960; -; 2.
DR   InterPro; IPR021740; Velvet.
DR   InterPro; IPR037525; Velvet_dom.
DR   InterPro; IPR038491; Velvet_dom_sf.
DR   PANTHER; PTHR33572; PTHR33572; 2.
DR   Pfam; PF11754; Velvet; 1.
DR   PROSITE; PS51821; VELVET; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..485
FT                   /note="Velvet complex subunit B"
FT                   /id="PRO_0000435912"
FT   DOMAIN          33..459
FT                   /note="Velvet"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT   REGION          107..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..157
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..220
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..248
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        263..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   485 AA;  52958 MW;  88CCED77498784A6 CRC64;
     MIQHTNARQS SVAIAPLRQL VSDSPEQWGY WLGRKHYSLE VVQHPLRARM CGFGDKDRRP
     LAPAAVAKMV VRRDDNSIVD VDDMDCSFFL VTVDLWSEDG KHETNLVLHP SSVDRHIPPH
     SSTKSRRRGT SSSAPQSRAP ANQTPSGGST PTLSQHRPGE QRPPLPHPHA SGYNNQGYVT
     PHAPQVNDAL GFPPSTPYGP TQADSSWGYP PPPPGDRSTS FPHPTLPSIH TLGRSPSSST
     SDHWNSEPEP QSLPYGAWNT DAPYHPSISS YSNSQVDPSV RNHSNSEGIE NPGWSSSEAT
     SPHSQADHAA YESSTYHHSA YHPAPTHSQM APGTCSSQHV STVPPPPRHT YTRTLVGPLS
     ANACRLLDEH RKPGIFFLFQ DLSVRTEGTF RLRMRLMNVG APPAPEVGAA RVHNDVSPVL
     AQTFTEQFTV YSAKRFPGVP DTTALSIALG NQGQKLPLAS DGLSEALVEE SSRVQQASET
     QWFRV