ID   VELB_MAGO7              Reviewed;         441 AA.
AC   G4MUB2;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Velvet complex subunit B {ECO:0000305};
GN   Name=VELB {ECO:0000303|PubMed:24632440}; ORFNames=MGG_01620;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24632440; DOI=10.1016/j.fgb.2014.02.011;
RA   Kim H.J., Han J.H., Kim K.S., Lee Y.H.;
RT   "Comparative functional analysis of the velvet gene family reveals unique
RT   roles in fungal development and pathogenicity in Magnaporthe oryzae.";
RL   Fungal Genet. Biol. 66:33-43(2014).
CC   -!- FUNCTION: Component of the velvet transcription factor complex that
CC       controls sexual/asexual developmental ratio in response to light,
CC       promoting sexual development in the darkness while stimulating asexual
CC       sporulation under illumination (PubMed:24632440). The velvet complex
CC       acts as a global regulator for secondary metabolite gene expression (By
CC       similarity). Component of the VELB-VOSA heterodimeric complex that
CC       plays a dual role in activating genes associated with spore maturation
CC       and repressing certain development-associated genes (By similarity).
CC       The VELB-VOSA complex binds DNA through the DNA-binding domain of VOSA
CC       that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3'
CC       consisting of two motifs in the promoters of key developmental
CC       regulatory genes (By similarity). Involved in the regulation of the
CC       response to eactive oxygen species (ROS) stress (PubMed:24632440).
CC       {ECO:0000250|UniProtKB:C8VTS4, ECO:0000269|PubMed:24632440}.
CC   -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC       LAEA, VEA and VELB; VEA acting as a bridging protein between LAEA and
CC       VELB (By similarity). Forms a heterodimeric complex with VOSA; the
CC       formation of the VELB-VOSA complex is light-dependent (By similarity).
CC       {ECO:0000250|UniProtKB:C8VTS4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTS4}. Cytoplasm
CC       {ECO:0000250|UniProtKB:C8VTS4}. Note=Nuclear localization is mediated
CC       by VEA (By similarity). {ECO:0000250|UniProtKB:C8VTS4}.
CC   -!- DISRUPTION PHENOTYPE: Leads to reduced formation of conidia
CC       (PubMed:24632440). {ECO:0000269|PubMed:24632440}.
CC   -!- SIMILARITY: Belongs to the velvet family. VelB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CM001232; EHA54799.1; -; Genomic_DNA.
DR   RefSeq; XP_003714606.1; XM_003714558.1.
DR   AlphaFoldDB; G4MUB2; -.
DR   SMR; G4MUB2; -.
DR   STRING; 318829.MGG_01620T0; -.
DR   EnsemblFungi; MGG_01620T0; MGG_01620T0; MGG_01620.
DR   GeneID; 2679081; -.
DR   KEGG; mgr:MGG_01620; -.
DR   VEuPathDB; FungiDB:MGG_01620; -.
DR   eggNOG; ENOG502S1B4; Eukaryota.
DR   HOGENOM; CLU_022491_0_1_1; -.
DR   InParanoid; G4MUB2; -.
DR   OMA; KIGVWFI; -.
DR   OrthoDB; 1407766at2759; -.
DR   PHI-base; PHI:4112; -.
DR   Proteomes; UP000009058; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.3960; -; 2.
DR   InterPro; IPR021740; Velvet.
DR   InterPro; IPR037525; Velvet_dom.
DR   InterPro; IPR038491; Velvet_dom_sf.
DR   PANTHER; PTHR33572; PTHR33572; 1.
DR   Pfam; PF11754; Velvet; 1.
DR   PROSITE; PS51821; VELVET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..441
FT                   /note="Velvet complex subunit B"
FT                   /id="PRO_0000435908"
FT   DOMAIN          100..426
FT                   /note="Velvet"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT   REGION          1..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   441 AA;  47466 MW;  48F0B6C3CF01A2B0 CRC64;
     MNPGYSSTAS QPGHNPSALP HDVHHALPAI GHPGSYHASM PQLPSIPPSM PPHYSDQYGM
     MQQPQDQPAP SSTTEGGAET KPSADAVART QKKLQPHVGE QDGRKYRLDV VQQPKRARMC
     GFGDKDRRPI TPPPCIRLIV TDAVTGKEID CNEIEHTMYV LNVDLWSEDA QQEVNLVRHT
     SATPSISSTT PASFAQIDST PPAFAQIPGT NREMPSYPQS QAYAPSVTPF AQQGGYGQQA
     ISPVGPHYGM VANTYGGQGG YTYASPTDMH PHQLGSQVGP YGPRIFNGAP DMGMHQRMAL
     QGTHQGAPPQ GMFTRNLIGS LSASAFRLND PQEKIGIWFV LQDLSVRTEG IFRLRFSYVN
     VGAPTRTPNG GPANQTSILN TGKAPILASC FSDAFQVYSA KKFPGVCEST PLSKCFAGQG
     IKIPIRKAEG GGKNNDDDDD Y