ID   VELB_SCHCM              Reviewed;         536 AA.
AC   D8PJU0;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Velvet complex subunit B {ECO:0000305};
GN   Name=velB {ECO:0000303|PubMed:24942908}; ORFNames=SCHCODRAFT_255145;
OS   Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX   NCBI_TaxID=578458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H4-8 / FGSC 9210;
RX   PubMed=20622885; DOI=10.1038/nbt.1643;
RA   Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA   de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA   Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA   Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA   Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA   Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA   Woesten H.A.B.;
RT   "Genome sequence of the model mushroom Schizophyllum commune.";
RL   Nat. Biotechnol. 28:957-963(2010).
RN   [2]
RP   INDUCTION.
RX   PubMed=24942908; DOI=10.1186/1471-2164-15-492;
RA   Plaza D.F., Lin C.W., van der Velden N.S., Aebi M., Kuenzler M.;
RT   "Comparative transcriptomics of the model mushroom Coprinopsis cinerea
RT   reveals tissue-specific armories and a conserved circuitry for sexual
RT   development.";
RL   BMC Genomics 15:492-492(2014).
CC   -!- FUNCTION: Component of the velvet transcription factor complex that
CC       controls sexual/asexual developmental ratio in response to light,
CC       promoting sexual development in the darkness while stimulating asexual
CC       sporulation under illumination (By similarity). The velvet complex acts
CC       as a global regulator for secondary metabolite gene expression (By
CC       similarity). Component of the velB-VosA heterodimeric complex that
CC       plays a dual role in activating genes associated with spore maturation
CC       and repressing certain development-associated genes (By similarity).
CC       The velB-VosA complex binds DNA through the DNA-binding domain of vosA
CC       that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3'
CC       consisting of two motifs in the promoters of key developmental
CC       regulatory genes (By similarity). {ECO:0000250|UniProtKB:C8VTS4}.
CC   -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC       laeA, veA and velB; VeA acting as a bridging protein between laeA and
CC       velB (By similarity). Forms a heterodimeric complex with vosA; the
CC       formation of the velB-vosA complex is light-dependent (By similarity).
CC       {ECO:0000250|UniProtKB:C8VTS4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTS4}. Cytoplasm
CC       {ECO:0000250|UniProtKB:C8VTS4}. Note=Nuclear localization is mediated
CC       by veA (By similarity). {ECO:0000250|UniProtKB:C8VTS4}.
CC   -!- INDUCTION: Expression is down-regulated during fruiting body formation
CC       (PubMed:24942908). {ECO:0000269|PubMed:24942908}.
CC   -!- SIMILARITY: Belongs to the velvet family. VelB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; GL377302; EFJ03233.1; -; Genomic_DNA.
DR   RefSeq; XP_003038135.1; XM_003038089.1.
DR   AlphaFoldDB; D8PJU0; -.
DR   STRING; 578458.D8PJU0; -.
DR   EnsemblFungi; EFJ03233; EFJ03233; SCHCODRAFT_255145.
DR   GeneID; 9588259; -.
DR   KEGG; scm:SCHCODRAFT_255145; -.
DR   eggNOG; ENOG502S1B4; Eukaryota.
DR   HOGENOM; CLU_022491_4_0_1; -.
DR   InParanoid; D8PJU0; -.
DR   OMA; MIQKTNA; -.
DR   OrthoDB; 1407766at2759; -.
DR   Proteomes; UP000007431; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.3960; -; 2.
DR   InterPro; IPR021740; Velvet.
DR   InterPro; IPR037525; Velvet_dom.
DR   InterPro; IPR038491; Velvet_dom_sf.
DR   PANTHER; PTHR33572; PTHR33572; 2.
DR   Pfam; PF11754; Velvet; 1.
DR   PROSITE; PS51821; VELVET; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..536
FT                   /note="Velvet complex subunit B"
FT                   /id="PRO_0000435913"
FT   DOMAIN          25..512
FT                   /note="Velvet"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          157..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          508..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..143
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..208
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..262
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..305
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..344
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        350..401
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  56704 MW;  DF78A40F775CBFBD CRC64;
     MIQRTTDPAA GSSTSGPPTN SLSWGSRHNG KLYTLEVVQH PIRARMCGFG DKDRRPLAPA
     AVATMNVYRE DNTQVEVDDI DCSFFLVTVD LWSEDGKQEM NLVLHPNAAQ DRGPPMPAKP
     RRPTNPPPPS NTHGSPPAPA IPFPSYGPPT PYYPPWSAPA SDRSPSSASA VLPSISTSFG
     RAPGPSSATP YGPQYGPPSA SSYGPPSASA YGPPSASAYG PPSASAYGPP SASTYGPSSA
     SAYGPPSSAS YGPPTSSYAS SYPPYHYGPP PPPFGNYGST SNFDHSQPVT SSVDQETNSP
     VVTTTARDDD QREGEASTSA AGNPRADPSN SGAPSTSPTA STMGRRESRG RRRRREEREG
     PDGGPDLREP IEPGSTKARE EEDARTGTEK GDPKDKSDAQ RATYTRTLVG PLSSNATRLL
     DEHRKPGIFF LFQDLSVRTE GTFRLRLRLM NVGAPPAPEP GAAGVHTGVS PVLAQVFTKP
     FTVFSAKRFP GVPDTTALSI AFNQQNMKLP LRNRHGSGSK RRRRGAGGGS DDEESD