ID   VELB_USTMA              Reviewed;         472 AA.
AC   A0A0D1CY03;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2015, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Velvet complex subunit umv2 {ECO:0000305};
GN   Name=umv2 {ECO:0000303|PubMed:24064149}; ORFNames=UMAG_01146;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24064149; DOI=10.1016/j.fgb.2013.09.002;
RA   Karakkat B.B., Gold S.E., Covert S.F.;
RT   "Two members of the Ustilago maydis velvet family influence teliospore
RT   development and virulence on maize seedlings.";
RL   Fungal Genet. Biol. 61:111-119(2013).
CC   -!- FUNCTION: Component of the velvet transcription factor complex that
CC       controls sexual/asexual developmental ratio in response to light,
CC       promoting sexual development in the darkness while stimulating asexual
CC       sporulation under illumination (By similarity). The velvet complex acts
CC       as a global regulator for secondary metabolite gene expression (By
CC       similarity). Component of the velB-VosA heterodimeric complex that
CC       plays a dual role in activating genes associated with spore maturation
CC       and repressing certain development-associated genes (By similarity).
CC       The velB-VosA complex binds DNA through the DNA-binding domain of vosA
CC       that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3'
CC       consisting of two motifs in the promoters of key developmental
CC       regulatory genes (By similarity). Required for full virulence on
CC       seedlings(PubMed:24064149). {ECO:0000250|UniProtKB:C8VTS4,
CC       ECO:0000269|PubMed:24064149}.
CC   -!- SUBUNIT: Component of the heterotrimeric velvet complex composed of
CC       laeA, veA and velB; VeA acting as a bridging protein between laeA and
CC       velB (By similarity). Forms a heterodimeric complex with vosA; the
CC       formation of the velB-vosA complex is light-dependent (By similarity).
CC       {ECO:0000250|UniProtKB:C8VTS4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C8VTS4}. Cytoplasm
CC       {ECO:0000250|UniProtKB:C8VTS4}. Note=Nuclear localization is mediated
CC       by veA (By similarity). {ECO:0000250|UniProtKB:C8VTS4}.
CC   -!- DISRUPTION PHENOTYPE: Leads to reduced virulence (PubMed:24064149).
CC       {ECO:0000269|PubMed:24064149}.
CC   -!- SIMILARITY: Belongs to the velvet family. VelB subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CM003141; KIS71243.1; -; Genomic_DNA.
DR   RefSeq; XP_011387094.1; XM_011388792.1.
DR   AlphaFoldDB; A0A0D1CY03; -.
DR   SMR; A0A0D1CY03; -.
DR   STRING; 5270.UM01146P0; -.
DR   EnsemblFungi; KIS71243; KIS71243; UMAG_01146.
DR   GeneID; 23562250; -.
DR   KEGG; uma:UMAG_01146; -.
DR   VEuPathDB; FungiDB:UMAG_01146; -.
DR   eggNOG; ENOG502S1B4; Eukaryota.
DR   OMA; LATDLCH; -.
DR   OrthoDB; 1407766at2759; -.
DR   Proteomes; UP000000561; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.3960; -; 1.
DR   InterPro; IPR021740; Velvet.
DR   InterPro; IPR037525; Velvet_dom.
DR   InterPro; IPR038491; Velvet_dom_sf.
DR   PANTHER; PTHR33572; PTHR33572; 1.
DR   Pfam; PF11754; Velvet; 1.
DR   PROSITE; PS51821; VELVET; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..472
FT                   /note="Velvet complex subunit umv2"
FT                   /id="PRO_0000435909"
FT   DOMAIN          158..441
FT                   /note="Velvet"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT   REGION          1..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          433..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..327
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..457
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   472 AA;  51458 MW;  B1E41A8A51737A19 CRC64;
     MSRSDTDGRD TSFASRNGVG GSQLSEPPSQ RRERPDYGYA VEETHRPHTA QERFPDSHGQ
     RSAPDLYSRD SDRFSYHRGD TLTPAQERSY QRELELMKAR GEQERSYGGA SASRSSRPLE
     ADHHYGGMPL TRGLVDDFAP EPMASSGRPN LEGFSRVENG RRYRLVVVQH PSRARMCGFG
     DKDRRPLSPT LIVKLIITEE ATGEEISPCE VNTSLFLLAT DLCHPDDLML APRNILVHHH
     ASSLSSNPIQ HGGAGGYATD EFGHRSGSSL GNFAADGGGP CDDGYRSSTH PQHASESTGA
     AALPLSSSSM NPYDRSPHAS SSIQFGGGGN FAQQSQAESY TRNLVGAAVA SASVLKDEQD
     KWCTFFVFQD ISVRTEGVYR IKLMFVNLEV SGRVGTGVAD ALAETYTDAF TVYSPRRFPG
     MLDPTPLSRK LASQGIKIPV RNDKKKQRRR NDEGGDGMGD YDGASGGDED DE