VELC_EMENI
ID VELC_EMENI Reviewed; 524 AA.
AC Q5BBM1; A5HMG6; C8VLN5;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Sexual development regulator velC {ECO:0000305};
GN Name=velC {ECO:0000303|PubMed:24587098}; ORFNames=ANIA_02059;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, INDUCTION, AND
RP INTERACTION WITH VOSA.
RX PubMed=24587098; DOI=10.1371/journal.pone.0089883;
RA Park H.S., Nam T.Y., Han K.H., Kim S.C., Yu J.H.;
RT "VelC positively controls sexual development in Aspergillus nidulans.";
RL PLoS ONE 9:E89883-E89883(2014).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Velvet-domain-containing protein that acts as a positive
CC regulator of sexual development (PubMed:24587098). Positively regulates
CC the production of the sexual fruiting bodies called cleistothecia
CC (PubMed:24587098). {ECO:0000269|PubMed:24587098}.
CC -!- SUBUNIT: Interacts with vosA (PubMed:24587098).
CC {ECO:0000269|PubMed:24587098}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Specifically accumulates during the early phase of sexual
CC development (PubMed:24587098). {ECO:0000269|PubMed:24587098}.
CC -!- DISRUPTION PHENOTYPE: Leads to increased number of conidia and reduced
CC production of cleistothecia (PubMed:24587098). Increases expression of
CC brlA, abaA, wetA and vosA genes that control sequential activation of
CC asexual sporulation (PubMed:24587098). {ECO:0000269|PubMed:24587098}.
CC -!- SIMILARITY: Belongs to the velvet family. VelC subfamily.
CC {ECO:0000305}.
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DR EMBL; EF540816; ABQ17968.1; -; mRNA.
DR EMBL; BN001307; CBF86097.1; -; Genomic_DNA.
DR EMBL; AACD01000032; EAA64891.1; -; Genomic_DNA.
DR RefSeq; XP_659663.1; XM_654571.1.
DR AlphaFoldDB; Q5BBM1; -.
DR SMR; Q5BBM1; -.
DR STRING; 162425.CADANIAP00008728; -.
DR EnsemblFungi; CBF86097; CBF86097; ANIA_02059.
DR EnsemblFungi; EAA64891; EAA64891; AN2059.2.
DR GeneID; 2874984; -.
DR KEGG; ani:AN2059.2; -.
DR VEuPathDB; FungiDB:AN2059; -.
DR eggNOG; ENOG502RYR6; Eukaryota.
DR HOGENOM; CLU_569822_0_0_1; -.
DR InParanoid; Q5BBM1; -.
DR OrthoDB; 920210at2759; -.
DR Proteomes; UP000000560; Chromosome VII.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043943; P:regulation of asexual sporulation resulting in formation of a cellular spore; IMP:AspGD.
DR GO; GO:0043940; P:regulation of sexual sporulation resulting in formation of a cellular spore; IMP:AspGD.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.3960; -; 1.
DR InterPro; IPR021740; Velvet.
DR InterPro; IPR037525; Velvet_dom.
DR InterPro; IPR038491; Velvet_dom_sf.
DR PANTHER; PTHR33572; PTHR33572; 1.
DR Pfam; PF11754; Velvet; 1.
DR PROSITE; PS51821; VELVET; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..524
FT /note="Sexual development regulator velC"
FT /id="PRO_0000435791"
FT DOMAIN 248..500
FT /note="Velvet"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT REGION 114..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 57329 MW; 4105EA7F1C357A24 CRC64;
MTTHVGPQTT LLHQTGQISA LIAGEAVQTC EASSCQMSGT PFQQWTYVTE GRYTNARTHP
SDEDRRRQTT VSNPRYLAQE PPRFLLPTAQ NNAPTMSQSA TYSTLPVQGF PEQNRVLDNR
SDPKYGPLPA TTGSLAQYSI QRPSTSRNME NAGSSSSYYD APSCSRGSVG SIGRMNDLDS
QYSGSTTAFP SPVHSDSSPI YPAIAPISGY QQQLPIHQRH TTSSMPSGFE NLLHHHSTSP
SPPPRCASSS SRYRLFIRQQ PLAARACGAG DRDRRPVDPP PIIQLLLTEF NPNSEKDRSI
LQDPRFTVGC LLYPVRNPSY LPGSGSGAGS SDTNTNSNDK SRHESMSSYS QLGINLEDSH
ATGQSTPLLS GKAFVSPFFV DEEPDPNTAP AHPSSTDDST YDASPRTVTH RFRNRPLPKP
PACFFIFSDL SVRTAGLYRL QFRLMNWGSI EDTGQSMPIL AEVWSEPFRV CAAKDFPGMR
DSSLLTLRLK ELGFVELKTR GQGMGKGRRV GIGSSKVSSR ARVE
