ID   VELC_GIBM7              Reviewed;         460 AA.
AC   W7MGR9;
DT   16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Sexual development regulator velC {ECO:0000305};
GN   Name=velC {ECO:0000303|PubMed:24792348}; ORFNames=FVEG_05214;
OS   Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS   fungus) (Fusarium verticillioides).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=334819;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M3125 / FGSC 7600;
RX   PubMed=20237561; DOI=10.1038/nature08850;
RA   Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA   Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA   Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA   Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA   Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA   Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA   Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA   Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA   Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA   Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA   Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA   Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT   "Comparative genomics reveals mobile pathogenicity chromosomes in
RT   Fusarium.";
RL   Nature 464:367-373(2010).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH VE1, AND FUNCTION.
RX   PubMed=24792348; DOI=10.1128/ec.00022-14;
RA   Lan N., Zhang H., Hu C., Wang W., Calvo A.M., Harris S.D., Chen S., Li S.;
RT   "Coordinated and distinct functions of velvet proteins in Fusarium
RT   verticillioides.";
RL   Eukaryot. Cell 13:909-918(2014).
CC   -!- FUNCTION: Velvet-domain-containing protein that acts as a positive
CC       regulator of sexual development (By similarity). Dispensable for
CC       regulation of conidial size, hyphal hydrophobicity, fumonisin
CC       production, and oxidant resistance (PubMed:24792348).
CC       {ECO:0000250|UniProtKB:Q5BBM1, ECO:0000269|PubMed:24792348}.
CC   -!- SUBUNIT: Interacts with VE1 (PubMed:24792348).
CC       {ECO:0000269|PubMed:24792348}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the velvet family. VelC subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DS022247; EWG43982.1; -; Genomic_DNA.
DR   RefSeq; XP_018750173.1; XM_018893331.1.
DR   AlphaFoldDB; W7MGR9; -.
DR   SMR; W7MGR9; -.
DR   GeneID; 30063223; -.
DR   KEGG; fvr:FVEG_05214; -.
DR   VEuPathDB; FungiDB:FVEG_05214; -.
DR   eggNOG; ENOG502RYR6; Eukaryota.
DR   OrthoDB; 1407766at2759; -.
DR   Proteomes; UP000009096; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.3960; -; 1.
DR   InterPro; IPR021740; Velvet.
DR   InterPro; IPR037525; Velvet_dom.
DR   InterPro; IPR038491; Velvet_dom_sf.
DR   PANTHER; PTHR33572; PTHR33572; 1.
DR   Pfam; PF11754; Velvet; 2.
DR   PROSITE; PS51821; VELVET; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..460
FT                   /note="Sexual development regulator velC"
FT                   /id="PRO_0000435792"
FT   DOMAIN          239..422
FT                   /note="Velvet"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT   REGION          67..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          422..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..453
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   460 AA;  51410 MW;  ADDECBC0BF1C76E3 CRC64;
     MSLTAVETAA GTSQRLNAMP QTMPEAMPHP HATTIMKWAP DTHYPPQGPV HSYYDQHLYS
     PTGQLIVGPD HRRPSQLQQH QHPRTGHGYQ LNGMPGSVPQ NQPHPPHSHP QSGLYATDHT
     AGQQAGPPQA PSAILQRNSE MLDHAQGRHP VYAPRSHSVS EDQPPTSVHG QHRPSIDMCA
     VPPFTEYHFN PPVTTNGRPP DSNSPMVSPT GLRPDPMRIA DILTTGERSR SRTSVDNRLS
     DNRFNLQIRQ QPVAARSCGF GERDRRVIDP PPIVQLLIKD DSLTKEEIAK HLRYPHYVMS
     CSIFDESGSC DASFMPEEYR QQRRLMGLLV SAPFVGKDEH GEEGCFFCFP DLSCRTPGSF
     RLHFTLVKID PIRAKEVKRF PTLVTAQSEV FTVYTAKDFP GMQASTKLTK RLKEQGCIIS
     IKKGNDRSKN TRSHDDSSDG EQDEGEATLQ GKRRRRSARQ