ID   VELC_MAGO7              Reviewed;         442 AA.
AC   G4NEE4;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Sexual development regulator VELC {ECO:0000305};
GN   Name=VELC {ECO:0000303|PubMed:24632440}; ORFNames=MGG_14719;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24632440; DOI=10.1016/j.fgb.2014.02.011;
RA   Kim H.J., Han J.H., Kim K.S., Lee Y.H.;
RT   "Comparative functional analysis of the velvet gene family reveals unique
RT   roles in fungal development and pathogenicity in Magnaporthe oryzae.";
RL   Fungal Genet. Biol. 66:33-43(2014).
CC   -!- FUNCTION: Velvet-domain-containing protein that acts as a positive
CC       regulator of sexual development (PubMed:24632440). Plays an important
CC       role in pathogenicity through regulating positively appressorium-
CC       mediated penetration and invasive growth (PubMed:24632440).
CC       {ECO:0000269|PubMed:24632440}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Leads to reduced formation of conidia
CC       (PubMed:24632440). Exhibits significantly reduced pathogenicity,
CC       developing only a few small necrotic lesions (PubMed:24632440).
CC       {ECO:0000269|PubMed:24632440}.
CC   -!- SIMILARITY: Belongs to the velvet family. VelC subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CM001235; EHA49421.1; -; Genomic_DNA.
DR   RefSeq; XP_003719005.1; XM_003718957.1.
DR   AlphaFoldDB; G4NEE4; -.
DR   SMR; G4NEE4; -.
DR   STRING; 242507.G4NEE4; -.
DR   PRIDE; G4NEE4; -.
DR   EnsemblFungi; MGG_14719T0; MGG_14719T0; MGG_14719.
DR   GeneID; 5049346; -.
DR   KEGG; mgr:MGG_14719; -.
DR   VEuPathDB; FungiDB:MGG_14719; -.
DR   eggNOG; ENOG502RYR6; Eukaryota.
DR   HOGENOM; CLU_022491_3_3_1; -.
DR   InParanoid; G4NEE4; -.
DR   OMA; ENGEDGC; -.
DR   OrthoDB; 1407766at2759; -.
DR   PHI-base; PHI:4111; -.
DR   Proteomes; UP000009058; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.3960; -; 1.
DR   InterPro; IPR021740; Velvet.
DR   InterPro; IPR037525; Velvet_dom.
DR   InterPro; IPR038491; Velvet_dom_sf.
DR   PANTHER; PTHR33572; PTHR33572; 1.
DR   Pfam; PF11754; Velvet; 2.
DR   PROSITE; PS51821; VELVET; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..442
FT                   /note="Sexual development regulator VELC"
FT                   /id="PRO_0000435919"
FT   DOMAIN          213..396
FT                   /note="Velvet"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT   REGION          1..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..56
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..126
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..167
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   442 AA;  47456 MW;  E66A55527A7EBB5B CRC64;
     MPVHFNQSVG MPPARDGARP PPIKGGLMGK LIPATYSPNG RHPRIAPPPP PTPPAGAGAG
     AGAAPPQRQL LQHSPTTAPG PRRPSNPSSP QHPQQPGIDR FPQIIPYQHE QPQRRPSRQQ
     YSASPPVDYS FGKGPKQSGL DQSSSTSSSV SPKQEMKQMS IHNLLSSGDQ DDQDDKSINN
     SNTARASSAS LASLASPRSV LPPAAMPSPS PSFSTSEYHL HVRQQPVAAR SCGFGERDRR
     VIDPPPIVQM TIDDPSATPD QMQQRLRHPF SVVHCSIYNE TGEEDNSAMP EDYRQQRRLM
     GTLVASPFVG KDENGEDGCF FCFPDLSCRT PGSFRLKFSL VVINPADMRQ GLRTPIAATA
     MSDVLVVYNA KDFPGMQAST PLTRKLKEQG CLISIKKGNE KGGGGGGGGP SGSRDQYSDD
     EYDDDGGGGS GRAGKRKRIR RS