ID   VELC_PENRW              Reviewed;         268 AA.
AC   B6HQN4;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Sexual development regulator velC {ECO:0000305};
GN   Name=velC {ECO:0000303|PubMed:23264641}; ORFNames=PCH_Pc22g11790;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
RN   [2]
RP   FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND INTERACTION WITH
RP   VOSA AND VELA.
RX   PubMed=23264641; DOI=10.1128/ec.00272-12;
RA   Kopke K., Hoff B., Bloemendal S., Katschorowski A., Kamerewerd J.,
RA   Kueck U.;
RT   "Members of the Penicillium chrysogenum velvet complex play functionally
RT   opposing roles in the regulation of penicillin biosynthesis and
RT   conidiation.";
RL   Eukaryot. Cell 12:299-310(2013).
CC   -!- FUNCTION: Velvet-domain-containing protein that acts as a positive
CC       regulator of sexual development (By similarity).
CC       {ECO:0000250|UniProtKB:Q5BBM1}.
CC   -!- SUBUNIT: Interacts with velA and vosA (PubMed:23264641).
CC       {ECO:0000269|PubMed:23264641}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23264641}.
CC   -!- DISRUPTION PHENOTYPE: Leads to a marked reduction in penicillin
CC       biosynthesis (PubMed:23264641). {ECO:0000269|PubMed:23264641}.
CC   -!- SIMILARITY: Belongs to the velvet family. VelC subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AM920437; CAP98467.1; -; Genomic_DNA.
DR   RefSeq; XP_002565125.1; XM_002565079.1.
DR   AlphaFoldDB; B6HQN4; -.
DR   SMR; B6HQN4; -.
DR   STRING; 1108849.XP_002565125.1; -.
DR   PRIDE; B6HQN4; -.
DR   EnsemblFungi; CAP98467; CAP98467; PCH_Pc22g11790.
DR   GeneID; 8309514; -.
DR   KEGG; pcs:Pc22g11790; -.
DR   VEuPathDB; FungiDB:PCH_Pc22g11790; -.
DR   eggNOG; ENOG502RYR6; Eukaryota.
DR   HOGENOM; CLU_054061_0_0_1; -.
DR   OMA; HIRQQPI; -.
DR   OrthoDB; 920210at2759; -.
DR   BioCyc; PCHR:PC22G11790-MON; -.
DR   Proteomes; UP000000724; Contig Pc00c22.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.3960; -; 1.
DR   InterPro; IPR021740; Velvet.
DR   InterPro; IPR037525; Velvet_dom.
DR   InterPro; IPR038491; Velvet_dom_sf.
DR   PANTHER; PTHR33572; PTHR33572; 1.
DR   Pfam; PF11754; Velvet; 2.
DR   PROSITE; PS51821; VELVET; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..268
FT                   /note="Sexual development regulator velC"
FT                   /id="PRO_0000435920"
FT   DOMAIN          28..257
FT                   /note="Velvet"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT   REGION          1..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          142..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..28
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..118
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   268 AA;  30422 MW;  20DD3CC52006EC3B CRC64;
     MPHGFDKLLH PEPEPQSPSP PPPPRRPSTQ SRYHLHIRQQ PIAARACGAG DRDRRPVDPP
     PIVQILLTDF DSNSQEDRDL LQDPRFTVGY RDGNRDRERE REHERERERE RETDGVARTD
     DNFSTPLLSG KAFMSPFYVD ADPDPNSAPA HPSSISDPHI SNPPHHVYNH AASRLHQPAT
     FFIFADLSIR SAGLYRLQFR LMNWGSVEDT GQSMPILAQA WSDPFRVYPA KDFPGMRDSS
     ILAEGLKELG FVELKTRGHG KGKGKKRR