VEM1_CAEEL
ID VEM1_CAEEL Reviewed; 183 AA.
AC Q7YZW5;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Protein vem-1 {ECO:0000305};
GN Name=vem-1 {ECO:0000312|WormBase:K07E3.8};
GN ORFNames=K07E3.8 {ECO:0000312|WormBase:K07E3.8};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, INTERACTION WITH UNC-40, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=15483120; DOI=10.1523/jneurosci.2385-04.2004;
RA Runko E., Kaprielian Z.;
RT "Caenorhabditis elegans VEM-1, a novel membrane protein, regulates the
RT guidance of ventral nerve cord-associated axons.";
RL J. Neurosci. 24:9015-9026(2004).
CC -!- FUNCTION: Transmembrane protein required for the axon guidance of a
CC subset of ventral nerve cord-associated interneurons and motor neurons.
CC May function with the netrin receptor unc-40 in axon guidance.
CC {ECO:0000269|PubMed:15483120}.
CC -!- SUBUNIT: Interacts with unc-40 (via cytoplasmic domain).
CC {ECO:0000269|PubMed:15483120}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}. Cell projection, axon
CC {ECO:0000269|PubMed:15483120}.
CC -!- TISSUE SPECIFICITY: Expressed in the AVG pioneer midline neuron and in
CC several nerve ring neurons that extend projecting axons into the right
CC ventral nerve cord. {ECO:0000269|PubMed:15483120}.
CC -!- DEVELOPMENTAL STAGE: During the 1.5 fold embryo stage, detected in the
CC AVG pioneer neuron and in the developing ventral nerve cord. At larval
CC stage L1, detected in the AVG, CEPDL/R, RMDVL/R, RIVL/R, AVAL/R,
CC RMDL/R, and RMDDL/R neurons. At larval stage L4, expression continues
CC in the AVG neuron and a subset of nerve ring neurons that extend axons
CC into the right ventral nerve cord. {ECO:0000269|PubMed:15483120}.
CC -!- DOMAIN: The cytochrome b5 heme-binding domain lacks the conserved iron-
CC binding His residues at positions 84 and 106. {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Axon guidance defects of nerve ring-associated
CC interneurons that extend their axons posteriorly into the right ventral
CC nerve cord as well as defects in the axon guidance of D-type motor
CC neurons that project their axons longitudinally along the ventral nerve
CC cord. No axon guidance defects are observed for the AVG midline neuron.
CC {ECO:0000269|PubMed:15483120}.
CC -!- SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.
CC {ECO:0000305}.
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DR EMBL; BX284606; CCD62520.1; -; Genomic_DNA.
DR RefSeq; NP_001024770.1; NM_001029599.6.
DR AlphaFoldDB; Q7YZW5; -.
DR SMR; Q7YZW5; -.
DR STRING; 6239.K07E3.8a; -.
DR EPD; Q7YZW5; -.
DR PaxDb; Q7YZW5; -.
DR PeptideAtlas; Q7YZW5; -.
DR EnsemblMetazoa; K07E3.8.1; K07E3.8.1; WBGene00006890.
DR GeneID; 181066; -.
DR KEGG; cel:CELE_K07E3.8; -.
DR UCSC; K07E3.8b.2; c. elegans.
DR CTD; 181066; -.
DR WormBase; K07E3.8; CE34578; WBGene00006890; vem-1.
DR eggNOG; KOG1110; Eukaryota.
DR GeneTree; ENSGT00940000169479; -.
DR HOGENOM; CLU_042860_1_1_1; -.
DR OrthoDB; 1331617at2759; -.
DR PRO; PR:Q7YZW5; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00006890; Expressed in larva and 4 other tissues.
DR GO; GO:0030424; C:axon; IDA:WormBase.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; HEP:WormBase.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR Gene3D; 3.10.120.10; -; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR Pfam; PF00173; Cyt-b5; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; SSF55856; 1.
PE 1: Evidence at protein level;
KW Cell projection; Membrane; Neurogenesis; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..183
FT /note="Protein vem-1"
FT /id="PRO_0000439234"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 47..146
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00279"
SQ SEQUENCE 183 AA; 20503 MW; A8425128DD398F44 CRC64;
MDLSSWFEFT MYDAVFLVVV LGFFFYWLTR SEQPLPAPPK ELAPLPMSDM TVEELRKYDG
VKNEHILFGL NGTIYDVTRG KGFYGPGKAY GTLAGHDATR ALGTMDQNAV SSEWDDHTGI
SADEQETANE WETQFKFKYL TVGRLVKNSS EKADYGNRKS FVRGAESLDS IINGGDEGTK
KDN
