VEMP_BC512
ID VEMP_BC512 Reviewed; 76 AA.
AC Q0Q464;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04205};
DE Short=E protein {ECO:0000255|HAMAP-Rule:MF_04205};
DE Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04205};
GN Name=E {ECO:0000255|HAMAP-Rule:MF_04205}; Synonyms=sM; ORFNames=4;
OS Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Alphacoronavirus; Pedacovirus.
OX NCBI_TaxID=693999;
OH NCBI_TaxID=153297; Scotophilus kuhlii (Lesser asiatic yellow bat).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=16840328; DOI=10.1128/jvi.00697-06;
RA Tang X.C., Zhang J.X., Zhang S.Y., Wang P., Fan X.H., Li L.F., Li G.,
RA Dong B.Q., Liu W., Cheung C.L., Xu K.M., Song W.J., Vijaykrishna D.,
RA Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H., Guan Y.;
RT "Prevalence and genetic diversity of coronaviruses in bats from China.";
RL J. Virol. 80:7481-7490(2006).
CC -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC Acts as a viroporin and self-assembles in host membranes forming
CC pentameric protein-lipid pores that allow ion transport. Also plays a
CC role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04205}.
CC -!- SUBUNIT: Homopentamer. Interacts with membrane protein M in the budding
CC compartment of the host cell, which is located between endoplasmic
CC reticulum and the Golgi complex. Interacts with Nucleoprotein.
CC {ECO:0000255|HAMAP-Rule:MF_04205}.
CC -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC Rule:MF_04205}; Single-pass type III membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_04205}. Note=The cytoplasmic tail functions
CC as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04205}.
CC -!- MISCELLANEOUS: Bat coronavirus 512/2005 is highly similar to porcine
CC epidemic diarrhea virus (PEDV).
CC -!- SIMILARITY: Belongs to the alphacoronaviruses E protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04205}.
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DR EMBL; DQ648858; ABG47080.1; -; Genomic_RNA.
DR RefSeq; YP_001351686.1; NC_009657.1.
DR GeneID; 11266520; -.
DR KEGG; vg:11266520; -.
DR Proteomes; UP000113079; Genome.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04205; ALPHA_CORONA_E; 1.
DR InterPro; IPR043507; E_protein_aCoV.
DR InterPro; IPR003873; E_protein_CoV.
DR Pfam; PF02723; CoV_E; 1.
DR PROSITE; PS51926; COV_E; 1.
PE 3: Inferred from homology;
KW Apoptosis; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..76
FT /note="Envelope small membrane protein"
FT /id="PRO_0000289932"
FT TOPO_DOM 1..14
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT TOPO_DOM 36..76
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
SQ SEQUENCE 76 AA; 8739 MW; 4A8DB5DBB4666DE3 CRC64;
MLQLVNDNGV VVNAILWLFV LFFVLVISIT FVQLINLCFT CHRLCNNVVY KPVGKVYGVY
KSYMRIQPLT SDIIQV
