VEMP_BCRP3
ID VEMP_BCRP3 Reviewed; 76 AA.
AC Q3I5J3;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 07-APR-2021, entry version 68.
DE RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04204};
DE Short=E protein {ECO:0000255|HAMAP-Rule:MF_04204};
DE Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04204};
GN Name=E {ECO:0000255|HAMAP-Rule:MF_04204}; Synonyms=sM; ORFNames=4;
OS Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Betacoronavirus; Sarbecovirus.
OX NCBI_TaxID=349344;
OH NCBI_TaxID=59479; Rhinolophus ferrumequinum (Greater horseshoe bat).
OH NCBI_TaxID=196889; Rhinolophus macrotis (Big-eared horseshoe bat).
OH NCBI_TaxID=188571; Rhinolophus pearsonii.
OH NCBI_TaxID=89399; Rhinolophus sinicus (Chinese rufous horseshoe bat).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=16195424; DOI=10.1126/science.1118391;
RA Li W., Shi Z., Yu M., Ren W., Smith C., Epstein J.H., Wang H., Crameri G.,
RA Hu Z., Zhang H., Zhang J., McEachern J., Field H., Daszak P., Eaton B.T.,
RA Zhang S., Wang L.F.;
RT "Bats are natural reservoirs of SARS-like coronaviruses.";
RL Science 310:676-679(2005).
CC -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC Acts as a viroporin and self-assembles in host membranes forming
CC pentameric protein-lipid pores that allow ion transport. Also plays a
CC role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04204}.
CC -!- SUBUNIT: Homopentamer. Interacts with membrane protein M in the budding
CC compartment of the host cell, which is located between endoplasmic
CC reticulum and the Golgi complex. Interacts with Nucleoprotein.
CC {ECO:0000255|HAMAP-Rule:MF_04204}.
CC -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC Rule:MF_04204}; Single-pass type III membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_04204}. Note=The cytoplasmic tail functions
CC as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04204}.
CC -!- MISCELLANEOUS: Bat coronavirus rp3 is highly similar to SARS-CoV (SARS-
CC like).
CC -!- SIMILARITY: Belongs to the betacoronaviruses E protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04204}.
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DR EMBL; DQ071615; AAZ67054.1; -; Genomic_RNA.
DR SMR; Q3I5J3; -.
DR Proteomes; UP000006570; Genome.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR CDD; cd21536; SARS-CoV-2_E; 1.
DR HAMAP; MF_04204; BETA_CORONA_E; 1.
DR InterPro; IPR043506; E_protein_bCoV.
DR InterPro; IPR003873; E_protein_CoV.
DR InterPro; IPR044377; E_SARS-CoV-2.
DR Pfam; PF02723; CoV_E; 1.
DR PROSITE; PS51926; COV_E; 1.
PE 3: Inferred from homology;
KW Apoptosis; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..76
FT /note="Envelope small membrane protein"
FT /id="PRO_0000106073"
FT TOPO_DOM 1..16
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04204"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04204"
FT TOPO_DOM 38..76
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04204"
SQ SEQUENCE 76 AA; 8361 MW; A6D9A31652DDA194 CRC64;
MYSFVSEETG TLIVNSVLLF LAFVVFLLVT LAILTALRLC AYCCNIVNVS LVKPTVYVYS
RVKNLNSSEG VPDLLV
