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VEMP_CVBON
ID   VEMP_CVBON              Reviewed;          84 AA.
AC   P0C2Q6; Q77N11; Q77WX9;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   07-APR-2021, entry version 49.
DE   RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04204};
DE            Short=E protein {ECO:0000255|HAMAP-Rule:MF_04204};
DE            Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04204};
GN   Name=E {ECO:0000255|HAMAP-Rule:MF_04204}; Synonyms=sM; ORFNames=5b;
OS   Bovine coronavirus (strain Ontario) (BCoV) (BCV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Embecovirus.
OX   NCBI_TaxID=231422;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate BCO.43277, and Isolate BCO.44175;
RX   PubMed=11376845; DOI=10.1016/s0168-1702(01)00243-x;
RA   Gelinas A.-M., Boutin M., Sasseville A.M.-J., Dea S.;
RT   "Bovine coronaviruses associated with enteric and respiratory diseases in
RT   Canadian dairy cattle display different reactivities to anti-HE monoclonal
RT   antibodies and distinct amino acid changes in their HE, S and ns4.9
RT   protein.";
RL   Virus Res. 76:43-57(2001).
CC   -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC       Acts as a viroporin and self-assembles in host membranes forming
CC       pentameric protein-lipid pores that allow ion transport. Also plays a
CC       role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04204}.
CC   -!- SUBUNIT: Homopentamer. Interacts with membrane protein M in the budding
CC       compartment of the host cell, which is located between endoplasmic
CC       reticulum and the Golgi complex. Interacts with Nucleoprotein.
CC       {ECO:0000255|HAMAP-Rule:MF_04204}.
CC   -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04204}; Single-pass type III membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_04204}. Note=The cytoplasmic tail functions
CC       as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04204}.
CC   -!- SIMILARITY: Belongs to the betacoronaviruses E protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04204}.
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DR   EMBL; AF239310; AAG60548.1; -; Genomic_RNA.
DR   EMBL; AF239311; AAG40627.1; -; Genomic_DNA.
DR   RefSeq; NP_150081.1; NC_003045.1.
DR   GeneID; 921685; -.
DR   KEGG; vg:921685; -.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR   GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR   CDD; cd21532; HKU1-CoV-like_E; 1.
DR   HAMAP; MF_04204; BETA_CORONA_E; 1.
DR   InterPro; IPR043506; E_protein_bCoV.
DR   InterPro; IPR003873; E_protein_CoV.
DR   Pfam; PF02723; CoV_E; 1.
DR   PROSITE; PS51926; COV_E; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..84
FT                   /note="Envelope small membrane protein"
FT                   /id="PRO_0000283972"
FT   TOPO_DOM        1..18
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04204"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04204"
FT   TOPO_DOM        40..80
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04204"
SQ   SEQUENCE   84 AA;  9584 MW;  5361C97F6D44DC00 CRC64;
     MFMADAYFAD TVWYVGQIIF IVAICLLVII VVVAFLATFK LCIQLCGMCN TLVLSPSIYV
     FNRGRQFYEF YNDVKPPVLD VDDV
 
 
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