ID   VEMP_CVCAI              Reviewed;          82 AA.
AC   P36696;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   23-FEB-2022, entry version 79.
DE   RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04205};
DE            Short=E protein {ECO:0000255|HAMAP-Rule:MF_04205};
DE            Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04205};
GN   Name=E {ECO:0000255|HAMAP-Rule:MF_04205}; Synonyms=sM;
OS   Canine coronavirus (strain Insavc-1) (CCoV) (Canine enteric coronavirus).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Alphacoronavirus; Tegacovirus.
OX   NCBI_TaxID=36391;
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1431811; DOI=10.1099/0022-1317-73-11-2849;
RA   Horsburgh B.C., Brierley I., Brown T.D.K.;
RT   "Analysis of a 9.6 kb sequence from the 3' end of canine coronavirus
RT   genomic RNA.";
RL   J. Gen. Virol. 73:2849-2862(1992).
CC   -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC       Acts as a viroporin and self-assembles in host membranes forming
CC       pentameric protein-lipid pores that allow ion transport. Also plays a
CC       role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04205}.
CC   -!- SUBUNIT: Homopentamer. Interacts with membrane protein M in the budding
CC       compartment of the host cell, which is located between endoplasmic
CC       reticulum and the Golgi complex. Interacts with Nucleoprotein.
CC       {ECO:0000255|HAMAP-Rule:MF_04205}.
CC   -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04205}; Single-pass type III membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_04205}. Note=The cytoplasmic tail functions
CC       as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04205}.
CC   -!- SIMILARITY: Belongs to the alphacoronaviruses E protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04205}.
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DR   EMBL; D13096; BAA02412.1; -; Genomic_RNA.
DR   PIR; JQ1723; JQ1723.
DR   SMR; P36696; -.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR   GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04205; ALPHA_CORONA_E; 1.
DR   InterPro; IPR043507; E_protein_aCoV.
DR   InterPro; IPR003873; E_protein_CoV.
DR   Pfam; PF02723; CoV_E; 1.
DR   PROSITE; PS51926; COV_E; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..82
FT                   /note="Envelope small membrane protein"
FT                   /id="PRO_0000106084"
FT   TOPO_DOM        1..19
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT   TOPO_DOM        41..82
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
SQ   SEQUENCE   82 AA;  9374 MW;  1DA6BF3E30D2E8F6 CRC64;
     MTFPRALTVI DDNGMVISII FWFLLIIILI LFSIALLNII KLCMVCCNLG RTVIIVPARH
     AYDAYKNFMQ IRAYNPDEAL LV