ID   VEMP_CVCBG              Reviewed;          82 AA.
AC   Q7T6T0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   02-DEC-2020, entry version 59.
DE   RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04205};
DE            Short=E protein {ECO:0000255|HAMAP-Rule:MF_04205};
DE            Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04205};
GN   Name=E {ECO:0000255|HAMAP-Rule:MF_04205}; Synonyms=sM;
OS   Canine coronavirus (strain BGF10) (CCoV) (Canine enteric coronavirus).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Alphacoronavirus; Tegacovirus.
OX   NCBI_TaxID=441619;
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15177889; DOI=10.1016/j.virusres.2004.02.038;
RA   Sanchez-Morgado J.M., Poynter S., Morris T.H.;
RT   "Molecular characterization of a virulent canine coronavirus BGF strain.";
RL   Virus Res. 104:27-31(2004).
CC   -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC       Acts as a viroporin and self-assembles in host membranes forming
CC       pentameric protein-lipid pores that allow ion transport. Also plays a
CC       role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04205}.
CC   -!- SUBUNIT: Homopentamer. Interacts with membrane protein M in the budding
CC       compartment of the host cell, which is located between endoplasmic
CC       reticulum and the Golgi complex. Interacts with Nucleoprotein.
CC       {ECO:0000255|HAMAP-Rule:MF_04205}.
CC   -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04205}; Single-pass type III membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_04205}. Note=The cytoplasmic tail functions
CC       as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04205}.
CC   -!- SIMILARITY: Belongs to the alphacoronaviruses E protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04205}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY342160; AAQ17223.1; -; Genomic_RNA.
DR   PRIDE; Q7T6T0; -.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR   GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04205; ALPHA_CORONA_E; 1.
DR   InterPro; IPR043507; E_protein_aCoV.
DR   InterPro; IPR003873; E_protein_CoV.
DR   Pfam; PF02723; CoV_E; 1.
DR   PROSITE; PS51926; COV_E; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..82
FT                   /note="Envelope small membrane protein"
FT                   /id="PRO_0000289933"
FT   TOPO_DOM        1..19
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT   TOPO_DOM        41..82
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
SQ   SEQUENCE   82 AA;  9379 MW;  0BD7DDB7390DFB7C CRC64;
     MTFPRALTVI DDNGMVISII FWLLLIIILI LFSIALLNII KLCMVCCNLG RTVVVIPVRH
     AYDAYKNFMR INAYNHNEAL LV