VEMP_CVH22
ID VEMP_CVH22 Reviewed; 77 AA.
AC P19741; Q01162;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 02-JUN-2021, entry version 93.
DE RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04205};
DE Short=E protein {ECO:0000255|HAMAP-Rule:MF_04205};
DE Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04205};
GN Name=E {ECO:0000255|HAMAP-Rule:MF_04205}; Synonyms=sM; ORFNames=5;
OS Human coronavirus 229E (HCoV-229E).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Alphacoronavirus; Duvinacovirus.
OX NCBI_TaxID=11137;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=2701946; DOI=10.1093/nar/17.15.6387;
RA Raabe T., Siddell S.G.;
RT "Nucleotide sequence of the human coronavirus HCV 229E mRNA 4 and mRNA 5
RT unique regions.";
RL Nucleic Acids Res. 17:6387-6387(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=1373555; DOI=10.1016/0168-1702(92)90039-c;
RA Jouvenne P., Mounir S., Stewart J.N., Richardson C.D., Talbot P.J.;
RT "Sequence analysis of human coronavirus 229E mRNAs 4 and 5: evidence for
RT polymorphism and homology with myelin basic protein.";
RL Virus Res. 22:125-141(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=11369870; DOI=10.1099/0022-1317-82-6-1273;
RA Thiel V., Herold J., Schelle B., Siddell S.G.;
RT "Infectious RNA transcribed in vitro from a cDNA copy of the human
RT coronavirus genome cloned in vaccinia virus.";
RL J. Gen. Virol. 82:1273-1281(2001).
CC -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC Acts as a viroporin and self-assembles in host membranes forming
CC pentameric protein-lipid pores that allow ion transport. Also plays a
CC role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04205}.
CC -!- SUBUNIT: Homopentamer. Interacts with membrane protein M in the budding
CC compartment of the host cell, which is located between endoplasmic
CC reticulum and the Golgi complex. Interacts with Nucleoprotein.
CC {ECO:0000255|HAMAP-Rule:MF_04205}.
CC -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC Rule:MF_04205}; Single-pass type III membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_04205}. Note=The cytoplasmic tail functions
CC as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04205}.
CC -!- SIMILARITY: Belongs to the alphacoronaviruses E protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04205}.
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DR EMBL; X15654; CAA33684.1; -; Genomic_RNA.
DR EMBL; X64942; CAA46114.1; -; Genomic_RNA.
DR EMBL; AF304460; AAG48595.1; -; Genomic_RNA.
DR PIR; C34038; MNIHH3.
DR PIR; S25709; S25709.
DR RefSeq; NP_073554.1; NC_002645.1.
DR SMR; P19741; -.
DR PRIDE; P19741; -.
DR DNASU; 918761; -.
DR GeneID; 918761; -.
DR KEGG; vg:918761; -.
DR Proteomes; UP000006716; Genome.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04205; ALPHA_CORONA_E; 1.
DR InterPro; IPR043507; E_protein_aCoV.
DR InterPro; IPR003873; E_protein_CoV.
DR Pfam; PF02723; CoV_E; 1.
DR PROSITE; PS51926; COV_E; 1.
PE 3: Inferred from homology;
KW Apoptosis; Host Golgi apparatus; Host membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..77
FT /note="Envelope small membrane protein"
FT /id="PRO_0000106072"
FT TOPO_DOM 1..15
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT TOPO_DOM 37..77
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT CONFLICT 36
FT /note="I -> T (in Ref. 2; CAA46114)"
FT CONFLICT 47
FT /note="N -> T (in Ref. 2; CAA46114)"
FT CONFLICT 50
FT /note="V -> I (in Ref. 2; CAA46114)"
FT CONFLICT 77
FT /note="F -> L (in Ref. 2; CAA46114)"
SQ SEQUENCE 77 AA; 9098 MW; 30CBC85F3FE211E4 CRC64;
MFLKLVDDHA LVVNVLLWCV VLIVILLVCI TIIKLIKLCF TCHMFCNRTV YGPIKNVYHI
YQSYMHIDPF PKRVIDF
