ID   VEMP_CVHN5              Reviewed;          82 AA.
AC   Q0ZME5;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04204};
DE            Short=E protein {ECO:0000255|HAMAP-Rule:MF_04204};
DE            Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04204};
GN   Name=E {ECO:0000255|HAMAP-Rule:MF_04204}; Synonyms=sM; ORFNames=5;
OS   Human coronavirus HKU1 (isolate N5) (HCoV-HKU1).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Embecovirus.
OX   NCBI_TaxID=443241;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16809319; DOI=10.1128/jvi.00509-06;
RA   Woo P.C.Y., Lau S.K.P., Yip C.C.Y., Huang Y., Tsoi H.-W., Chan K.-H.,
RA   Yuen K.-Y.;
RT   "Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel
RT   genotype and evidence of natural recombination in coronavirus HKU1.";
RL   J. Virol. 80:7136-7145(2006).
CC   -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC       Acts as a viroporin and self-assembles in host membranes forming
CC       pentameric protein-lipid pores that allow ion transport. Also plays a
CC       role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04204}.
CC   -!- SUBUNIT: Homopentamer. Interacts with membrane protein M in the budding
CC       compartment of the host cell, which is located between endoplasmic
CC       reticulum and the Golgi complex. Interacts with Nucleoprotein.
CC       {ECO:0000255|HAMAP-Rule:MF_04204}.
CC   -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04204}; Single-pass type III membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_04204}. Note=The cytoplasmic tail functions
CC       as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04204}.
CC   -!- MISCELLANEOUS: Isolate N5 belongs to genotype C. Genotype C probably
CC       arose from recombination between genotypes A and B.
CC   -!- SIMILARITY: Belongs to the betacoronaviruses E protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04204}.
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DR   EMBL; DQ339101; ABC70721.1; -; Genomic_RNA.
DR   Proteomes; UP000001985; Genome.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR   GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR   CDD; cd21532; HKU1-CoV-like_E; 1.
DR   HAMAP; MF_04204; BETA_CORONA_E; 1.
DR   InterPro; IPR043506; E_protein_bCoV.
DR   InterPro; IPR003873; E_protein_CoV.
DR   Pfam; PF02723; CoV_E; 1.
DR   PROSITE; PS51926; COV_E; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..82
FT                   /note="Envelope small membrane protein"
FT                   /id="PRO_0000297814"
FT   TOPO_DOM        1..16
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04204"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04204"
FT   TOPO_DOM        38..78
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04204"
SQ   SEQUENCE   82 AA;  9381 MW;  930F017D7A19B0EC CRC64;
     MVDVFFTDTA WYVGQIFFLV LSCVIFLIFV VALLATIKLC IQICGFCNIF IISPSAYVYN
     RGRQLYKSYS EHVIPSTLDD LI