VEMP_CVMS
ID VEMP_CVMS Reviewed; 88 AA.
AC P29076;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 07-APR-2021, entry version 78.
DE RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04204};
DE Short=E protein {ECO:0000255|HAMAP-Rule:MF_04204};
DE Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04204};
GN Name=E {ECO:0000255|HAMAP-Rule:MF_04204}; Synonyms=sM; ORFNames=5b;
OS Murine coronavirus (strain S) (MHV-S) (Murine hepatitis virus).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Betacoronavirus; Embecovirus.
OX NCBI_TaxID=11145;
OH NCBI_TaxID=10090; Mus musculus (Mouse).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=1654456; DOI=10.1128/jvi.65.10.5605-5608.1991;
RA Yokomori K., Lai M.M.C.;
RT "Mouse hepatitis virus S RNA sequence reveals that nonstructural proteins
RT ns4 and ns5a are not essential for murine coronavirus replication.";
RL J. Virol. 65:5605-5608(1991).
CC -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC Acts as a viroporin and self-assembles in host membranes forming
CC pentameric protein-lipid pores that allow ion transport. Also plays a
CC role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04204}.
CC -!- SUBUNIT: Homopentamer. Interacts with membrane protein M in the budding
CC compartment of the host cell, which is located between endoplasmic
CC reticulum and the Golgi complex. Interacts with Nucleoprotein.
CC {ECO:0000255|HAMAP-Rule:MF_04204}.
CC -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC Rule:MF_04204}; Single-pass type III membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_04204}. Note=The cytoplasmic tail functions
CC as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04204}.
CC -!- SIMILARITY: Belongs to the betacoronaviruses E protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04204}.
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DR EMBL; M64835; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR PIR; B40512; MNIHM5.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR CDD; cd21532; HKU1-CoV-like_E; 1.
DR HAMAP; MF_04204; BETA_CORONA_E; 1.
DR InterPro; IPR043506; E_protein_bCoV.
DR InterPro; IPR003873; E_protein_CoV.
DR Pfam; PF02723; CoV_E; 1.
DR PROSITE; PS51926; COV_E; 1.
PE 3: Inferred from homology;
KW Apoptosis; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..88
FT /note="Envelope small membrane protein"
FT /id="PRO_0000106089"
FT TOPO_DOM 1..16
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04204"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04204"
FT TOPO_DOM 38..79
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04204"
SQ SEQUENCE 88 AA; 10111 MW; BC20A6ED42BB525E CRC64;
MFNLFLTDTV WYVGQIIFIV AVCLMVTITV VAFLASIKLC IQLCGLCNTL VLSPSIYLYD
RSKQLYKYYN EEVRPPPLEV DDIIIQTL