VEMP_CVPR8
ID VEMP_CVPR8 Reviewed; 82 AA.
AC P69611; P24415;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 1.
DT 07-OCT-2020, entry version 59.
DE RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04205};
DE Short=E protein {ECO:0000255|HAMAP-Rule:MF_04205};
DE Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04205};
GN Name=E {ECO:0000255|HAMAP-Rule:MF_04205}; Synonyms=NS4;
OS Porcine respiratory coronavirus (strain 86/137004 / isolate British)
OS (PRCoV) (PRCV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Alphacoronavirus; Tegacovirus.
OX NCBI_TaxID=33736;
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=1662846; DOI=10.1016/0168-1702(91)90032-q;
RA Britton P., Mawditt K.L., Page K.W.;
RT "The cloning and sequencing of the virion protein genes from a British
RT isolate of porcine respiratory coronavirus: comparison with transmissible
RT gastroenteritis virus genes.";
RL Virus Res. 21:181-198(1991).
CC -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC Acts as a viroporin and self-assembles in host membranes forming
CC pentameric protein-lipid pores that allow ion transport. Also plays a
CC role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04205}.
CC -!- SUBUNIT: Homopentamer. Interacts with membrane protein M in the budding
CC compartment of the host cell, which is located between endoplasmic
CC reticulum and the Golgi complex. Interacts with Nucleoprotein.
CC {ECO:0000255|HAMAP-Rule:MF_04205}.
CC -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC Rule:MF_04205}; Single-pass type III membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_04205}. Note=The cytoplasmic tail functions
CC as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04205}.
CC -!- SIMILARITY: Belongs to the alphacoronaviruses E protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04205}.
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DR EMBL; X55980; CAA39451.1; -; Genomic_RNA.
DR EMBL; X60056; CAA42655.1; -; Genomic_RNA.
DR PIR; S24280; S24280.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04205; ALPHA_CORONA_E; 1.
DR InterPro; IPR043507; E_protein_aCoV.
DR InterPro; IPR003873; E_protein_CoV.
DR Pfam; PF02723; CoV_E; 1.
DR PROSITE; PS51926; COV_E; 1.
PE 3: Inferred from homology;
KW Apoptosis; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..82
FT /note="Envelope small membrane protein"
FT /id="PRO_0000106093"
FT TOPO_DOM 1..19
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT TOPO_DOM 41..82
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
SQ SEQUENCE 82 AA; 9268 MW; 5BE4CAB85DC688F4 CRC64;
MTFPRALTVI DDNGMVISII FWFLLIIILI LLSIALLNII KLCMVCCNLG RTVIIVPVQH
AYDAYKNFMR IKAYNPDGAL LV