VEMP_FIPV
ID VEMP_FIPV Reviewed; 82 AA.
AC Q52PA5; Q4U5F9;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 23-FEB-2022, entry version 61.
DE RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04205};
DE Short=E protein {ECO:0000255|HAMAP-Rule:MF_04205};
DE Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04205};
GN Name=E {ECO:0000255|HAMAP-Rule:MF_04205}; Synonyms=sM;
OS Feline coronavirus (strain FIPV WSU-79/1146) (FCoV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Alphacoronavirus; Tegacovirus.
OX NCBI_TaxID=33734;
OH NCBI_TaxID=9681; Felidae (cat family).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=16033972; DOI=10.1099/vir.0.80985-0;
RA Dye C., Siddell S.G.;
RT "Genomic RNA sequence of Feline coronavirus strain FIPV WSU-79/1146.";
RL J. Gen. Virol. 86:2249-2253(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA Haijema B.J., de Groot-Mijnes J.D.F., Vennema H., Raamsman M.J.,
RA Rottier P.J.M., de Groot R.J.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC Acts as a viroporin and self-assembles in host membranes forming
CC pentameric protein-lipid pores that allow ion transport. Also plays a
CC role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04205}.
CC -!- SUBUNIT: Homopentamer. Interacts with membrane protein M in the budding
CC compartment of the host cell, which is located between endoplasmic
CC reticulum and the Golgi complex. Interacts with Nucleoprotein.
CC {ECO:0000255|HAMAP-Rule:MF_04205}.
CC -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC Rule:MF_04205}; Single-pass type III membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_04205}. Note=The cytoplasmic tail functions
CC as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04205}.
CC -!- SIMILARITY: Belongs to the alphacoronaviruses E protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04205}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ010921; AAY32597.1; -; Genomic_RNA.
DR EMBL; AY994055; AAY16378.1; -; Genomic_RNA.
DR RefSeq; YP_004070197.1; NC_002306.3.
DR SMR; Q52PA5; -.
DR TCDB; 1.A.65.1.3; the coronavirus viroporin e protein (viroporin e) family.
DR GeneID; 10040184; -.
DR KEGG; vg:10040184; -.
DR Proteomes; UP000000835; Genome.
DR Proteomes; UP000140386; Genome.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04205; ALPHA_CORONA_E; 1.
DR InterPro; IPR043507; E_protein_aCoV.
DR InterPro; IPR003873; E_protein_CoV.
DR Pfam; PF02723; CoV_E; 1.
DR PROSITE; PS51926; COV_E; 1.
PE 3: Inferred from homology;
KW Apoptosis; Host Golgi apparatus; Host membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..82
FT /note="Envelope small membrane protein"
FT /id="PRO_0000283978"
FT TOPO_DOM 1..19
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
FT TOPO_DOM 41..82
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04205"
SQ SEQUENCE 82 AA; 9370 MW; BDC8A97C401F110D CRC64;
MTFPRAFTII DDHGMVVSVF FWLLLIIILI LFSIALLNVI KLCMVCCNLG KTIIVLPARH
AYDAYKTFMQ TKAYNPDEAF LV
