VEMP_IBVM
ID VEMP_IBVM Reviewed; 109 AA.
AC P05139; Q0GNB5; Q5I5X6;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 2.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04206};
DE Short=E protein {ECO:0000255|HAMAP-Rule:MF_04206};
DE Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04206};
GN Name=E {ECO:0000255|HAMAP-Rule:MF_04206}; Synonyms=sM; ORFNames=3c;
OS Avian infectious bronchitis virus (strain M41) (IBV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Gammacoronavirus; Igacovirus.
OX NCBI_TaxID=11127;
OH NCBI_TaxID=9031; Gallus gallus (Chicken).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=1653486; DOI=10.1016/0042-6822(91)90423-9;
RA Liu D.X., Cavanagh D., Green P., Inglis S.C.;
RT "A polycistronic mRNA specified by the coronavirus infectious bronchitis
RT virus.";
RL Virology 184:531-544(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=3960740; DOI=10.1093/nar/14.7.3144;
RA Niesters H.G.M., Zijderveld A.J., Seifert W.F., Lenstra J.A.,
RA Bleumink-Pluym N.M.C., Horzinek M.C., van der Zeijst B.A.M.;
RT "Infectious bronchitis virus RNA D encodes three potential translation
RT products.";
RL Nucleic Acids Res. 14:3144-3144(1986).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RA Mondal S.P., Buckles E.L.;
RT "Avian infectious bronchitis virus strain M41.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16934878; DOI=10.1016/j.jviromet.2006.07.018;
RA Callison S.A., Hilt D.A., Boynton T.O., Sample B.F., Robison R.,
RA Swayne D.E., Jackwood M.W.;
RT "Development and evaluation of a real-time Taqman RT-PCR assay for the
RT detection of infectious bronchitis virus from infected chickens.";
RL J. Virol. Methods 138:60-65(2006).
CC -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC Acts as a viroporin and self-assembles in host membranes forming
CC pentameric protein-lipid pores that allow ion transport. Also plays a
CC role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04206}.
CC -!- SUBUNIT: Homooligomer. Interacts with the M membrane protein in the
CC budding compartment of the host cell, which is located between
CC endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of
CC both proteins are important for this function. Interacts with
CC Nucleoprotein. {ECO:0000255|HAMAP-Rule:MF_04206}.
CC -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC Rule:MF_04206}; Single-pass type III membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_04206}. Note=The cytoplasmic tail functions
CC as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04206}.
CC -!- SIMILARITY: Belongs to the gammacoronaviruses E protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04206}.
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DR EMBL; X59542; CAA42117.1; -; Genomic_RNA.
DR EMBL; X03723; CAA27360.1; -; Genomic_RNA.
DR EMBL; DQ834384; ABI26426.1; -; Genomic_RNA.
DR EMBL; AY851295; AAW33789.1; -; Genomic_RNA.
DR PIR; C41038; WMIHB3.
DR Proteomes; UP000007642; Genome.
DR Proteomes; UP000096468; Genome.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04206; GAMMA_CORONA_E; 1.
DR InterPro; IPR003873; E_protein_CoV.
DR InterPro; IPR005296; IBV_3C.
DR Pfam; PF03620; IBV_3C; 1.
DR PROSITE; PS51926; COV_E; 1.
PE 3: Inferred from homology;
KW Apoptosis; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..109
FT /note="Envelope small membrane protein"
FT /id="PRO_0000106080"
FT TOPO_DOM 1..11
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04206"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04206"
FT TOPO_DOM 33..109
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04206"
FT REGION 89..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 22
FT /note="I -> F"
FT VARIANT 83
FT /note="V -> F"
FT VARIANT 102
FT /note="A -> V"
SQ SEQUENCE 109 AA; 12379 MW; 481F27B61728E0E3 CRC64;
MMNLLNKSLE ENGSFLTALY IIVGFLALYL LGRALQAFVQ AADACCLFWY TWVVIPGAKG
TAFVYKYTYG RKLNNPELEA VIVNEFPKNG WNNKNPANFQ DAQRDKLYS
