ID   VEMP_IBVP3              Reviewed;          93 AA.
AC   P30246;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   23-FEB-2022, entry version 69.
DE   RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04206};
DE            Short=E protein {ECO:0000255|HAMAP-Rule:MF_04206};
DE            Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04206};
GN   Name=E {ECO:0000255|HAMAP-Rule:MF_04206}; Synonyms=sM; ORFNames=3c;
OS   Avian infectious bronchitis virus (strain Portugal/322/82) (IBV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Gammacoronavirus; Igacovirus.
OX   NCBI_TaxID=31625;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1653486; DOI=10.1016/0042-6822(91)90423-9;
RA   Liu D.X., Cavanagh D., Green P., Inglis S.C.;
RT   "A polycistronic mRNA specified by the coronavirus infectious bronchitis
RT   virus.";
RL   Virology 184:531-544(1991).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=1962461; DOI=10.1016/0042-6822(91)90572-s;
RA   Liu D.X., Inglis S.C.;
RT   "Association of the infectious bronchitis virus 3c protein with the virion
RT   envelope.";
RL   Virology 185:911-917(1991).
CC   -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC       Acts as a viroporin and self-assembles in host membranes forming
CC       pentameric protein-lipid pores that allow ion transport. Also plays a
CC       role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04206}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the M membrane protein in the
CC       budding compartment of the host cell, which is located between
CC       endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of
CC       both proteins are important for this function. Interacts with
CC       Nucleoprotein. {ECO:0000255|HAMAP-Rule:MF_04206}.
CC   -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04206}; Single-pass type III membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_04206}. Note=The cytoplasmic tail functions
CC       as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04206}.
CC   -!- SIMILARITY: Belongs to the gammacoronaviruses E protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04206}.
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DR   EMBL; X59819; CAA42489.1; -; Genomic_RNA.
DR   PIR; I41038; WMIHB9.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR   GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04206; GAMMA_CORONA_E; 1.
DR   InterPro; IPR003873; E_protein_CoV.
DR   InterPro; IPR005296; IBV_3C.
DR   Pfam; PF03620; IBV_3C; 1.
DR   PROSITE; PS51926; COV_E; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..93
FT                   /note="Envelope small membrane protein"
FT                   /id="PRO_0000106081"
FT   TOPO_DOM        1..11
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04206"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04206"
FT   TOPO_DOM        33..93
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04206"
SQ   SEQUENCE   93 AA;  10556 MW;  1A4E80D96CFCC120 CRC64;
     MMNLLNKSLE ENGSVLTAFY IFVAFVALYL LGRALQAFVQ AADACCLFWY TWVVVPGAKG
     TTFVYKHTYG KKLNKPELET VIVNEFPKNG WKQ