ID   VEMP_IBVU4              Reviewed;         106 AA.
AC   P30247;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   23-FEB-2022, entry version 71.
DE   RecName: Full=Envelope small membrane protein {ECO:0000255|HAMAP-Rule:MF_04206};
DE            Short=E protein {ECO:0000255|HAMAP-Rule:MF_04206};
DE            Short=sM protein {ECO:0000255|HAMAP-Rule:MF_04206};
GN   Name=E {ECO:0000255|HAMAP-Rule:MF_04206}; Synonyms=sM; ORFNames=3c;
OS   Avian infectious bronchitis virus (strain UK/68/84) (IBV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Gammacoronavirus; Igacovirus.
OX   NCBI_TaxID=31630;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1653486; DOI=10.1016/0042-6822(91)90423-9;
RA   Liu D.X., Cavanagh D., Green P., Inglis S.C.;
RT   "A polycistronic mRNA specified by the coronavirus infectious bronchitis
RT   virus.";
RL   Virology 184:531-544(1991).
CC   -!- FUNCTION: Plays a central role in virus morphogenesis and assembly.
CC       Acts as a viroporin and self-assembles in host membranes forming
CC       pentameric protein-lipid pores that allow ion transport. Also plays a
CC       role in the induction of apoptosis. {ECO:0000255|HAMAP-Rule:MF_04206}.
CC   -!- SUBUNIT: Homooligomer. Interacts with the M membrane protein in the
CC       budding compartment of the host cell, which is located between
CC       endoplasmic reticulum and the Golgi complex. The cytoplasmic tails of
CC       both proteins are important for this function. Interacts with
CC       Nucleoprotein. {ECO:0000255|HAMAP-Rule:MF_04206}.
CC   -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04206}; Single-pass type III membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_04206}. Note=The cytoplasmic tail functions
CC       as a Golgi complex-targeting signal. {ECO:0000255|HAMAP-Rule:MF_04206}.
CC   -!- SIMILARITY: Belongs to the gammacoronaviruses E protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04206}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X60712; CAA43124.1; -; Genomic_RNA.
DR   PIR; C36816; WMIH23.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0044662; P:disruption by virus of host cell membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:InterPro.
DR   GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04206; GAMMA_CORONA_E; 1.
DR   InterPro; IPR003873; E_protein_CoV.
DR   InterPro; IPR005296; IBV_3C.
DR   Pfam; PF03620; IBV_3C; 1.
DR   PROSITE; PS51926; COV_E; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..106
FT                   /note="Envelope small membrane protein"
FT                   /id="PRO_0000106082"
FT   TOPO_DOM        1..11
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04206"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04206"
FT   TOPO_DOM        33..106
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04206"
SQ   SEQUENCE   106 AA;  11906 MW;  9CC90AF662F67C92 CRC64;
     MMNLLNTSLE ENGSFLTALY VICEFVALYL LGRALQAFVQ AADACCLFWY TWVVVPGAKG
     TAFVYKHTYG KKLNNPELEA VIVNEFPKNG WNNKNPANFQ NGKLHT