VENT1_XENTR
ID VENT1_XENTR Reviewed; 262 AA.
AC Q28ET4; Q6F2E1; Q804C8;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Homeobox protein vent1;
DE Short=Vent-1;
GN Name=vent1 {ECO:0000250|UniProtKB:Q91926};
GN Synonyms=vent-1 {ECO:0000250|UniProtKB:Q91926}; ORFNames=TGas069i16.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAO31758.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC TISSUE=Gastrula {ECO:0000269|PubMed:12050139};
RX PubMed=12050139; DOI=10.1242/dev.129.12.2917;
RA Polli M., Amaya E.;
RT "A study of mesoderm patterning through the analysis of the regulation of
RT Xmyf-5 expression.";
RL Development 129:2917-2927(2002).
RN [2] {ECO:0000312|EMBL:AAT72005.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT "Sequence of Xenopus tropicalis development genes.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAT72005.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83433.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional repressor. Cooperates with vent2 in a ventral
CC signaling pathway downstream of bmp4, which antagonizes the Spemann
CC organizer and dorsal mesoderm formation, and leads to ventral mesoderm
CC formation. Acts downstream of bmp4 to repress transcription of foxa4-
CC B/XFD-1'. Binds to DNA with preference for the target sequence 5'-
CC CTATT[T/C]G-3'. Also binds 5'-TGCATTTTG-3' at a lower frequency, and
CC occasionally 5'-TTGATC-3'. Binds to the homeobox 2 (HBX2) repressor
CC element in the promoter of the myf5 gene (By similarity). Cooperates
CC with vent2 to repress myf5 expression in the ventral domain.
CC {ECO:0000250|UniProtKB:Q91926, ECO:0000269|PubMed:12050139}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DOMAIN: The N-terminal region is required for repressor function.
CC {ECO:0000250|UniProtKB:Q91926}.
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DR EMBL; AY187017; AAO31758.1; -; mRNA.
DR EMBL; AC149072; AAT72005.1; -; Genomic_DNA.
DR EMBL; CR762353; CAJ83433.1; -; mRNA.
DR RefSeq; NP_988861.1; NM_203530.1.
DR AlphaFoldDB; Q28ET4; -.
DR SMR; Q28ET4; -.
DR PaxDb; Q28ET4; -.
DR Ensembl; ENSXETT00000019491; ENSXETP00000019491; ENSXETG00000008879.
DR GeneID; 394455; -.
DR KEGG; xtr:394455; -.
DR CTD; 394455; -.
DR Xenbase; XB-GENE-920868; ventx1.2.
DR eggNOG; KOG0488; Eukaryota.
DR HOGENOM; CLU_100253_0_0_1; -.
DR InParanoid; Q28ET4; -.
DR OMA; FTIDWIL; -.
DR OrthoDB; 1369499at2759; -.
DR TreeFam; TF351607; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000008879; Expressed in gastrula and 7 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.
DR GO; GO:0048264; P:determination of ventral identity; ISS:UniProtKB.
DR GO; GO:0001707; P:mesoderm formation; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..262
FT /note="Homeobox protein vent1"
FT /id="PRO_0000279724"
FT DNA_BIND 127..186
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 16..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..127
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 191
FT /note="H -> P (in Ref. 1; AAO31758)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="F -> L (in Ref. 1; AAO31758 and 2; AAT72005)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 262 AA; 29802 MW; 461FC16E871F62A7 CRC64;
MVQQGFSIDL ILARNREEAP DGKDSVSSRP HIPCAPQPLA PTKYAKEIPR RKDGQEQGEI
TSFQCSSEEA RNRQFSNPSL PALHRSSGSS DEFSPAGSED DGTESSGRNS QENDTEHRSK
SPKSDLQRRL RTAFTPQQIT RLEQAFNKQR YLGASERKKL ATSLQLSEIQ VKTWFQNRRM
KLKRQIQDQQ HSMVPPPVCY PQTFSYYPGG FPVPLNSGSF YQPPAHPFQA PQHSFIPQPL
HHHMRMSAHQ EQFPPLFGAQ YM
