VENTX_HUMAN
ID VENTX_HUMAN Reviewed; 258 AA.
AC O95231; Q32MZ3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Homeobox protein VENTX;
DE AltName: Full=VENT homeobox homolog;
DE AltName: Full=VENT-like homeobox protein 2;
GN Name=VENTX; Synonyms=HPX42B, VENTX2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Bone marrow;
RX PubMed=11549314; DOI=10.1006/geno.2001.6574;
RA Moretti P.A.B., Davidson A.J., Baker E., Lilley B., Zon L.I.,
RA D'Andrea R.J.;
RT "Molecular cloning of a human Vent-like homeobox gene.";
RL Genomics 76:21-29(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-42.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in ventralization.
CC -!- INTERACTION:
CC O95231; Q8NFV4-4: ABHD11; NbExp=3; IntAct=EBI-10191303, EBI-12318443;
CC O95231; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-10191303, EBI-10173507;
CC O95231; Q03989: ARID5A; NbExp=5; IntAct=EBI-10191303, EBI-948603;
CC O95231; P15289: ARSA; NbExp=3; IntAct=EBI-10191303, EBI-2117357;
CC O95231; Q8N1L9: BATF2; NbExp=3; IntAct=EBI-10191303, EBI-742695;
CC O95231; O14503: BHLHE40; NbExp=3; IntAct=EBI-10191303, EBI-711810;
CC O95231; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-10191303, EBI-12809220;
CC O95231; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-10191303, EBI-11976299;
CC O95231; Q6P1W5: C1orf94; NbExp=4; IntAct=EBI-10191303, EBI-946029;
CC O95231; Q6UXA7: C6orf15; NbExp=3; IntAct=EBI-10191303, EBI-11990870;
CC O95231; P40199: CEACAM6; NbExp=3; IntAct=EBI-10191303, EBI-4314501;
CC O95231; Q5T4B2: CERCAM; NbExp=3; IntAct=EBI-10191303, EBI-12261896;
CC O95231; P23141-3: CES1; NbExp=3; IntAct=EBI-10191303, EBI-12360993;
CC O95231; P27918: CFP; NbExp=5; IntAct=EBI-10191303, EBI-9038570;
CC O95231; Q03060-25: CREM; NbExp=3; IntAct=EBI-10191303, EBI-12884642;
CC O95231; P07498: CSN3; NbExp=3; IntAct=EBI-10191303, EBI-2602175;
CC O95231; P78358: CTAG1B; NbExp=5; IntAct=EBI-10191303, EBI-1188472;
CC O95231; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10191303, EBI-3867333;
CC O95231; O75553: DAB1; NbExp=4; IntAct=EBI-10191303, EBI-7875264;
CC O95231; Q15038: DAZAP2; NbExp=3; IntAct=EBI-10191303, EBI-724310;
CC O95231; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-10191303, EBI-12193763;
CC O95231; Q9NVL1-2: FAM86C1P; NbExp=3; IntAct=EBI-10191303, EBI-12845222;
CC O95231; Q9BZE0: GLIS2; NbExp=3; IntAct=EBI-10191303, EBI-7251368;
CC O95231; A0A024R5S0: hCG_2003792; NbExp=3; IntAct=EBI-10191303, EBI-10188461;
CC O95231; P31273: HOXC8; NbExp=3; IntAct=EBI-10191303, EBI-1752118;
CC O95231; Q5TA45: INTS11; NbExp=3; IntAct=EBI-10191303, EBI-748258;
CC O95231; Q6UXX5: ITIH6; NbExp=3; IntAct=EBI-10191303, EBI-11028396;
CC O95231; A4D0Q3: KIAA1218; NbExp=3; IntAct=EBI-10191303, EBI-14308786;
CC O95231; O76011: KRT34; NbExp=4; IntAct=EBI-10191303, EBI-1047093;
CC O95231; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10191303, EBI-10171774;
CC O95231; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10191303, EBI-1052037;
CC O95231; P59991: KRTAP12-2; NbExp=6; IntAct=EBI-10191303, EBI-10176379;
CC O95231; P60329: KRTAP12-4; NbExp=4; IntAct=EBI-10191303, EBI-10176396;
CC O95231; Q8IUB9: KRTAP19-1; NbExp=5; IntAct=EBI-10191303, EBI-12811111;
CC O95231; Q3LHN2: KRTAP19-2; NbExp=3; IntAct=EBI-10191303, EBI-12196745;
CC O95231; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-10191303, EBI-12805508;
CC O95231; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-10191303, EBI-10241353;
CC O95231; Q3LI59: KRTAP21-2; NbExp=3; IntAct=EBI-10191303, EBI-18395721;
CC O95231; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-10191303, EBI-3957672;
CC O95231; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-10191303, EBI-9996449;
CC O95231; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-10191303, EBI-3957694;
CC O95231; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-10191303, EBI-12111050;
CC O95231; Q3LI66: KRTAP6-2; NbExp=5; IntAct=EBI-10191303, EBI-11962084;
CC O95231; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-10191303, EBI-10261141;
CC O95231; Q99732: LITAF; NbExp=3; IntAct=EBI-10191303, EBI-725647;
CC O95231; Q8N1E2: LYG1; NbExp=3; IntAct=EBI-10191303, EBI-13309213;
CC O95231; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-10191303, EBI-716006;
CC O95231; Q9BRT3: MIEN1; NbExp=3; IntAct=EBI-10191303, EBI-6137472;
CC O95231; A1E959: ODAM; NbExp=3; IntAct=EBI-10191303, EBI-5774125;
CC O95231; Q9BZM2-2: PLA2G2F; NbExp=3; IntAct=EBI-10191303, EBI-12826629;
CC O95231; Q9UF11-2: PLEKHB1; NbExp=3; IntAct=EBI-10191303, EBI-12832742;
CC O95231; P78424: POU6F2; NbExp=3; IntAct=EBI-10191303, EBI-12029004;
CC O95231; P86480: PRR20D; NbExp=3; IntAct=EBI-10191303, EBI-12754095;
CC O95231; Q9NWB1-5: RBFOX1; NbExp=3; IntAct=EBI-10191303, EBI-12123390;
CC O95231; Q93062: RBPMS; NbExp=4; IntAct=EBI-10191303, EBI-740322;
CC O95231; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-10191303, EBI-372094;
CC O95231; P78317: RNF4; NbExp=3; IntAct=EBI-10191303, EBI-2340927;
CC O95231; Q01974: ROR2; NbExp=3; IntAct=EBI-10191303, EBI-6422642;
CC O95231; Q96LW2: RSKR; NbExp=3; IntAct=EBI-10191303, EBI-1054572;
CC O95231; Q16348: SLC15A2; NbExp=3; IntAct=EBI-10191303, EBI-12806032;
CC O95231; Q53HV7-2: SMUG1; NbExp=3; IntAct=EBI-10191303, EBI-12275818;
CC O95231; O95416: SOX14; NbExp=3; IntAct=EBI-10191303, EBI-9087806;
CC O95231; Q9C004: SPRY4; NbExp=3; IntAct=EBI-10191303, EBI-354861;
CC O95231; Q96PV0: SYNGAP1; NbExp=3; IntAct=EBI-10191303, EBI-2682386;
CC O95231; Q96SF7: TBX15; NbExp=4; IntAct=EBI-10191303, EBI-10191361;
CC O95231; O60806: TBX19; NbExp=3; IntAct=EBI-10191303, EBI-12096770;
CC O95231; Q9Y458: TBX22; NbExp=6; IntAct=EBI-10191303, EBI-6427217;
CC O95231; Q96M29: TEKT5; NbExp=3; IntAct=EBI-10191303, EBI-10239812;
CC O95231; Q7Z782: TMBIM4; NbExp=3; IntAct=EBI-10191303, EBI-12924766;
CC O95231; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-10191303, EBI-12038591;
CC O95231; Q15645: TRIP13; NbExp=3; IntAct=EBI-10191303, EBI-358993;
CC O95231; Q86WV8: TSC1; NbExp=3; IntAct=EBI-10191303, EBI-12806590;
CC O95231; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-10191303, EBI-2514383;
CC O95231; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-10191303, EBI-10180829;
CC O95231; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-10191303, EBI-947187;
CC O95231; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-10191303, EBI-11975223;
CC O95231; Q08AM6: VAC14; NbExp=3; IntAct=EBI-10191303, EBI-2107455;
CC O95231; Q6RSH7: VHLL; NbExp=3; IntAct=EBI-10191303, EBI-10254232;
CC O95231; Q9NZC7-5: WWOX; NbExp=5; IntAct=EBI-10191303, EBI-12040603;
CC O95231; A0A0C4DGF1: ZBTB32; NbExp=5; IntAct=EBI-10191303, EBI-10188476;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in bone marrow of patients recovering
CC from chemotherapy. Also expressed in an erythroleukemia cell line.
CC {ECO:0000269|PubMed:11549314}.
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DR EMBL; AF068006; AAC82375.1; -; mRNA.
DR EMBL; AF288039; AAK83043.1; -; Genomic_DNA.
DR EMBL; AL445199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC108915; AAI08916.1; -; mRNA.
DR EMBL; BC108916; AAI08917.1; -; mRNA.
DR CCDS; CCDS7675.1; -.
DR RefSeq; NP_055283.1; NM_014468.3.
DR AlphaFoldDB; O95231; -.
DR SMR; O95231; -.
DR BioGRID; 118111; 101.
DR IntAct; O95231; 87.
DR STRING; 9606.ENSP00000357556; -.
DR iPTMnet; O95231; -.
DR PhosphoSitePlus; O95231; -.
DR BioMuta; VENTX; -.
DR MassIVE; O95231; -.
DR PaxDb; O95231; -.
DR PeptideAtlas; O95231; -.
DR PRIDE; O95231; -.
DR ABCD; O95231; 3 sequenced antibodies.
DR Antibodypedia; 32622; 173 antibodies from 28 providers.
DR DNASU; 27287; -.
DR Ensembl; ENST00000325980.10; ENSP00000357556.5; ENSG00000151650.8.
DR GeneID; 27287; -.
DR KEGG; hsa:27287; -.
DR MANE-Select; ENST00000325980.10; ENSP00000357556.5; NM_014468.4; NP_055283.1.
DR UCSC; uc010quy.3; human.
DR CTD; 27287; -.
DR DisGeNET; 27287; -.
DR GeneCards; VENTX; -.
DR HGNC; HGNC:13639; VENTX.
DR HPA; ENSG00000151650; Low tissue specificity.
DR MIM; 607158; gene.
DR neXtProt; NX_O95231; -.
DR OpenTargets; ENSG00000151650; -.
DR PharmGKB; PA37803; -.
DR VEuPathDB; HostDB:ENSG00000151650; -.
DR eggNOG; KOG0488; Eukaryota.
DR GeneTree; ENSGT00940000163757; -.
DR HOGENOM; CLU_093885_0_0_1; -.
DR InParanoid; O95231; -.
DR OMA; KHKRQMQ; -.
DR OrthoDB; 1596695at2759; -.
DR PhylomeDB; O95231; -.
DR TreeFam; TF351607; -.
DR PathwayCommons; O95231; -.
DR Reactome; R-HSA-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR Reactome; R-HSA-8853884; Transcriptional Regulation by VENTX.
DR SignaLink; O95231; -.
DR BioGRID-ORCS; 27287; 13 hits in 1093 CRISPR screens.
DR GenomeRNAi; 27287; -.
DR Pharos; O95231; Tbio.
DR PRO; PR:O95231; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; O95231; protein.
DR Bgee; ENSG00000151650; Expressed in granulocyte and 88 other tissues.
DR Genevisible; O95231; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IMP:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..258
FT /note="Homeobox protein VENTX"
FT /id="PRO_0000305938"
FT DNA_BIND 91..150
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 42
FT /note="L -> P (in dbSNP:rs2240892)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_035243"
FT VARIANT 79
FT /note="M -> V (in dbSNP:rs2240891)"
FT /id="VAR_035244"
FT VARIANT 101
FT /note="E -> K (in dbSNP:rs2270192)"
FT /id="VAR_049591"
FT VARIANT 191
FT /note="G -> R (in dbSNP:rs9418952)"
FT /id="VAR_049592"
FT VARIANT 247
FT /note="G -> D (in dbSNP:rs9418953)"
FT /id="VAR_061269"
SQ SEQUENCE 258 AA; 27552 MW; 6F611169122D8244 CRC64;
MRLSSSPPRG PQQLSSFGSV DWLSQSSCSG PTHTPRPADF SLGSLPGPGQ TSGAREPPQA
VSIKEAAGSS NLPAPERTMA GLSKEPNTLR APRVRTAFTM EQVRTLEGVF QHHQYLSPLE
RKRLAREMQL SEVQIKTWFQ NRRMKHKRQM QDPQLHSPFS GSLHAPPAFY STSSGLANGL
QLLCPWAPLS GPQALMLPPG SFWGLCQVAQ EALASAGASC CGQPLASHPP TPGRPSLGPA
LSTGPRGLCA MPQTGDAF
