ID   VERU2_PENPO             Reviewed;         111 AA.
AC   A0A1V6NYZ6;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   03-AUG-2022, entry version 10.
DE   RecName: Full=Verrucosidin biosynthesis cluster protein U2 {ECO:0000303|PubMed:34093475};
DE   AltName: Full=Cluster 4 protein U2 {ECO:0000303|PubMed:34093475};
GN   Name=verU2 {ECO:0000303|PubMed:34093475};
GN   Synonyms=cl4U2 {ECO:0000303|PubMed:34093475}; ORFNames=PENPOL_c002G03902;
OS   Penicillium polonicum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=60169;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 4502;
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
RN   [2]
RP   FUNCTION.
RX   PubMed=34093475; DOI=10.3389/fmicb.2021.660871;
RA   Valente S., Piombo E., Schroeckh V., Meloni G.R., Heinekamp T.,
RA   Brakhage A.A., Spadaro D.;
RT   "CRISPR-Cas9-Based Discovery of the Verrucosidin Biosynthesis Gene Cluster
RT   in Penicillium polonicum.";
RL   Front. Microbiol. 12:660871-660871(2021).
CC   -!- FUNCTION: Part of the gene cluster that mediates the biosynthesis of
CC       the neurotoxin verrucosidin, a methylated alpha-pyrone polyketide that
CC       inhibits oxidative phosphorylation in mitochondria and thereby causes
CC       neurological diseases (PubMed:34093475). The carbon backbone of
CC       verrucosidin is synthesized by the HR-PKS verA, and further modified by
CC       the other verrucodidin cluster enzymes (Probable).
CC       {ECO:0000269|PubMed:34093475, ECO:0000305|PubMed:34093475}.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis.
CC       {ECO:0000305|PubMed:34093475}.
CC   -!- PATHWAY: Mycotoxin biosynthesis. {ECO:0000305|PubMed:34093475}.
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DR   EMBL; MDYM01000002; OQD69889.1; -; Genomic_DNA.
DR   UniPathway; UPA00213; -.
DR   Proteomes; UP000191408; Unassembled WGS sequence.
DR   GO; GO:0016114; P:terpenoid biosynthetic process; IEA:UniProtKB-UniPathway.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..111
FT                   /note="Verrucosidin biosynthesis cluster protein U2"
FT                   /id="PRO_0000455365"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   111 AA;  12770 MW;  CDFDA0654AA6003A CRC64;
     MSYKTNYELY SRGSIDSRRS PPPDELLSPL ATLYPHVAAL QPQYNPSNCT FTGYRDTGYW
     AAAYTTQTMD DSMSMRRIDG RPCRFVSKLR RLLSRDELKH RRGSRATART A