ID   VESP_DRYCN              Reviewed;         190 AA.
AC   F8RKW2;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Vespryn-21;
DE   Flags: Precursor;
OS   Drysdalia coronoides (White-lipped snake) (Hoplocephalus coronoides).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Notechinae; Drysdalia.
OX   NCBI_TaxID=66186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=21133350; DOI=10.1021/pr1008916;
RA   Chatrath S.T., Chapeaurouge A., Lin Q., Lim T.K., Dunstan N., Mirtschin P.,
RA   Kumar P.P., Kini R.M.;
RT   "Identification of novel proteins from the venom of a cryptic snake
RT   Drysdalia coronoides by a combined transcriptomics and proteomics
RT   approach.";
RL   J. Proteome Res. 10:739-750(2011).
CC   -!- FUNCTION: Neurotoxin that produces dose-dependent hypolocomotion and
CC       hyperalgesia in mice. May directly act on the central nervous system,
CC       as it is 6500-fold more potent when administered
CC       intracerebroventricularly than intraperitoneal (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the ohanin/vespryn family. {ECO:0000305}.
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DR   EMBL; HM627205; AEH95532.1; -; mRNA.
DR   AlphaFoldDB; F8RKW2; -.
DR   SMR; F8RKW2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR003877; SPRY_dom.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00589; PRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
PE   1: Evidence at protein level;
KW   Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..127
FT                   /note="Vespryn-21"
FT                   /id="PRO_0000425500"
FT   PROPEP          128..190
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000425501"
FT   DOMAIN          21..127
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
SQ   SEQUENCE   190 AA;  21119 MW;  52868E51B155F408 CRC64;
     MLLFTLCFFA DLENGGKALA SPPGKWQKAD VRFDSSTAFK SLVVSPDKKT VENVGVPQVV
     PDNPERFSSS PCVLGSPGFR SGRHFFEVRY GTQREWAVGL AGKSVKRKGY LRLVPEELIW
     QRGLWFLQRL ETDSDKLQKG SGKIVVFLDY SEGKVIFDQD GEVTTVQANF NGEEVVPFYY
     LGGGVSLTNL