ID   VESP_LACMU              Reviewed;         218 AA.
AC   Q27J48;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Ohanin-like protein;
DE   Flags: Precursor;
OS   Lachesis muta muta (Bushmaster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Lachesis.
OX   NCBI_TaxID=8753;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=16582429; DOI=10.1534/genetics.106.056515;
RA   Junqueira-de-Azevedo I.L.M., Ching A.T.C., Carvalho E., Faria F.,
RA   Nishiyama M.Y. Jr., Ho P.L., Diniz M.R.V.;
RT   "Lachesis muta (Viperidae) cDNAs reveal diverging pit viper molecules and
RT   scaffolds typical of cobra (Elapidae) venoms: implications for snake toxin
RT   repertoire evolution.";
RL   Genetics 173:877-889(2006).
CC   -!- FUNCTION: Neurotoxin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the ohanin/vespryn family. {ECO:0000305}.
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DR   EMBL; DQ396476; ABD52885.1; -; mRNA.
DR   AlphaFoldDB; Q27J48; -.
DR   SMR; Q27J48; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR003877; SPRY_dom.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
PE   2: Evidence at transcript level;
KW   Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..40
FT                   /evidence="ECO:0000255"
FT   PROPEP          41..48
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000253026"
FT   CHAIN           49..155
FT                   /note="Ohanin-like protein"
FT                   /id="PRO_0000253027"
FT   PROPEP          156..218
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000253028"
FT   DOMAIN          49..155
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
SQ   SEQUENCE   218 AA;  24179 MW;  4E5ADCFB662F94DF CRC64;
     MSPSAGFQFS LYFLQTKKVL WKLTGLCYIL LFTLCFFADQ ENGGKALASP PGIWKRADVT
     FDSNTAFSSL VVSANKKTVK NVGVPQVVPD NPERFNSSPC VLGSPGFRSG KHYFEVKYGT
     QREWAVGLAG KSVKRKGNLN LVPEERIWQT GLWWLRHLET DPGRVHSTSG KITVFVDYSG
     GNVIFDLNRI ITILKANFSG EEVVPFFYLG GTVSLTTL