ID   VESP_POGBA              Reviewed;         115 AA.
AC   Q2XXL4;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Vespryn;
DE   Flags: Precursor; Fragment;
OS   Pogona barbata (Bearded dragon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Acrodonta; Agamidae; Amphibolurinae; Pogona.
OX   NCBI_TaxID=52202;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=16292255; DOI=10.1038/nature04328;
RA   Fry B.G., Vidal N., Norman J.A., Vonk F.J., Scheib H., Ramjan S.F.R.,
RA   Kuruppu S., Fung K., Blair Hedges S., Richardson M.K., Hodgson W.C.,
RA   Ignjatovic V., Summerhayes R., Kochva E.;
RT   "Early evolution of the venom system in lizards and snakes.";
RL   Nature 439:584-588(2006).
CC   -!- FUNCTION: Neurotoxin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the ohanin/vespryn family. {ECO:0000305}.
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DR   EMBL; DQ139931; AAZ75637.1; -; mRNA.
DR   AlphaFoldDB; Q2XXL4; -.
DR   SMR; Q2XXL4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006574; PRY.
DR   Pfam; PF13765; PRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00589; PRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
PE   2: Evidence at transcript level;
KW   Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..>115
FT                   /note="Vespryn"
FT                   /id="PRO_0000253030"
FT   DOMAIN          22..>115
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   NON_TER         115
SQ   SEQUENCE   115 AA;  12875 MW;  32390ACDD5D913A0 CRC64;
     MTWLLLCLLA QYENGGKVLA LSSSAKPYKT SVRFDPKTAH PNLVVSQDKK TVTWVQEAQS
     VPDNPERFNS TPCLLGSPGF TSGKHYWEVE YGNQRELAAG VARKSVKRKD HLRLT