ID   VEX1_XENLA              Reviewed;         285 AA.
AC   Q9W769;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Homeobox protein vex1;
DE   AltName: Full=Homeodomain transcription factor vex-1;
DE   AltName: Full=Ventral homeobox protein;
DE   AltName: Full=Xvex-1;
GN   Name=vex1 {ECO:0000250|UniProtKB:Q6F2E2};
GN   Synonyms=vex-1 {ECO:0000312|EMBL:AAD42079.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAD42079.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   TISSUE=Gastrula {ECO:0000269|PubMed:10446269}, and
RC   Neurula {ECO:0000269|PubMed:10446269};
RX   PubMed=10446269; DOI=10.1016/s0925-4773(99)00120-3;
RA   Shapira E., Marom K., Yelin R., Levy A., Fainsod A.;
RT   "A role for the homeobox gene Xvex-1 as part of the BMP-4 ventral signaling
RT   pathway.";
RL   Mech. Dev. 86:99-111(1999).
RN   [2] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=10585564; DOI=10.1016/s0925-4773(99)00283-x;
RA   Shapira E., Marom K., Levy V., Yelin R., Fainsod A.;
RT   "The Xvex-1 antimorph reveals the temporal competence for organizer
RT   formation and an early role for ventral homeobox genes.";
RL   Mech. Dev. 90:77-87(2000).
CC   -!- FUNCTION: Transcriptional repressor. Acts in a ventral signaling
CC       pathway downstream of bmp4 to antagonize the Spemann organizer and
CC       ventrally pattern the embryonic mesoderm. Represses transcription of
CC       the dorsal genes gsc and otx2. {ECO:0000269|PubMed:10446269,
CC       ECO:0000269|PubMed:10585564}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Widely expressed in the embryo prior to
CC       gastrulation. Becomes restricted to the ventral marginal zone by
CC       mid/late gastrulation. Ventral localization persists during
CC       gastrulation and neurulation in the ventral region of the closed
CC       blastopore and in the proctodeum during tail bud stages.
CC       {ECO:0000269|PubMed:10446269}.
CC   -!- DEVELOPMENTAL STAGE: Expression begins at a low level shortly after the
CC       mid-blastula transition. Expression then increases during early and
CC       mid-gastrulation. {ECO:0000269|PubMed:10446269}.
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DR   EMBL; AF149307; AAD42079.1; -; mRNA.
DR   RefSeq; NP_001081954.1; NM_001088485.1.
DR   AlphaFoldDB; Q9W769; -.
DR   SMR; Q9W769; -.
DR   GeneID; 398140; -.
DR   KEGG; xla:398140; -.
DR   CTD; 398140; -.
DR   Xenbase; XB-GENE-864941; ventx3.2.S.
DR   OMA; CERSTDQ; -.
DR   OrthoDB; 1126595at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0030509; P:BMP signaling pathway; IGI:UniProtKB.
DR   GO; GO:0048264; P:determination of ventral identity; IMP:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..285
FT                   /note="Homeobox protein vex1"
FT                   /id="PRO_0000279725"
FT   DNA_BIND        131..190
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          30..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   285 AA;  32243 MW;  9A2AB3517DFE69D8 CRC64;
     MEKRPYSVEW LSESSQRKAV YSNADLLGYK SGNPDKESNI SLPSRATGPT LPSVDYREKE
     NYCVRNVQNE ERSPPVKDQL HSQPAPQELD TSRRALMVVP ACERSTDQGN KVTGTTDTNK
     KAKPVCDEDA AARARTKFSP EQLEELERSF KENRYIGSSE KRRLSKVLKL SETQIKTWFQ
     NRRMKFKRQT QDARVDAFFS GLYVPYYGYP DLPTPGYSVQ PEFSVLAPHT MAAPSLPFGP
     LQSTVISPGL HPTAIPSANL GSYPYSSMLV HPMLNEPKRQ RYSPY