ID   VEX1_XENTR              Reviewed;         282 AA.
AC   Q6F2E2;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Homeobox protein vex1;
DE   AltName: Full=Homeodomain transcription factor vex-1;
DE   AltName: Full=Ventral homeobox protein;
GN   Name=vex1 {ECO:0000303|Ref.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAT72004.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT   "Sequence of Xenopus tropicalis development genes.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor. Acts in a ventral signaling
CC       pathway downstream of bmp4 to antagonize the Spemann organizer and
CC       ventrally pattern the embryonic mesoderm. Represses transcription of
CC       the dorsal genes gsc and otx2 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9W769}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; AC149072; AAT72004.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6F2E2; -.
DR   SMR; Q6F2E2; -.
DR   STRING; 8364.ENSXETP00000058808; -.
DR   PaxDb; Q6F2E2; -.
DR   eggNOG; ENOG502SDSB; Eukaryota.
DR   InParanoid; Q6F2E2; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.
DR   GO; GO:0048264; P:determination of ventral identity; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..282
FT                   /note="Homeobox protein vex1"
FT                   /id="PRO_0000279726"
FT   DNA_BIND        129..188
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   282 AA;  32069 MW;  A3FFEF884A61DEA4 CRC64;
     MEKRPYSVAW LSESSQRKPL CTNVDLLGYK SGNPDLPPNR EYNVSLPSRV ILPTPDYREK
     ENYCGRNVHN GERSPPVRDQ LHFHPAPQEL TTSRRTSIEV SAESSTDQRV IGMTDTNKKT
     ISVCDEDAAS RARTKFTAEQ LEELEKSFKE NRYIGSSEKR RLSKVLKLSE NQIKTWFQNR
     RMKFKRQTQD ARVEAFFSGL YLPYYGYPDL PTPGYSVQSE FPVLAPQTMA ASSIPFGPLH
     STVMSPGLHP AIPSANLGSY PCSSMLVRPI LNEPTRQRYS PY