ID   VEXA_SALTI              Reviewed;         355 AA.
AC   Q04976;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Vi polysaccharide export protein VexA/TviF;
DE   Flags: Precursor;
GN   Name=vexA; Synonyms=tviF; OrderedLocusNames=STY4655, t4348;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GIFU 10007;
RX   PubMed=8331073; DOI=10.1128/jb.175.14.4456-4465.1993;
RA   Hashimoto Y., Li N., Yokoyama H., Ezaki T.;
RT   "Complete nucleotide sequence and molecular characterization of ViaB region
RT   encoding Vi antigen in Salmonella typhi.";
RL   J. Bacteriol. 175:4456-4465(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=8248629; DOI=10.1016/0923-2508(93)90193-6;
RA   Waxin H., Virlogeux I., Kolyva S., Popoff M.Y.;
RT   "Identification of six open reading frames in the Salmonella enterica
RT   subsp. enterica ser. Typhi viaB locus involved in Vi antigen production.";
RL   Res. Microbiol. 144:363-371(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: May form an ATP-driven capsule polysaccharide export
CC       apparatus, in association with the VexB, VexC and VexD proteins. May
CC       function as a membrane anchor for the polysaccharide. Possible porin
CC       properties.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BexD/CtrA/VexA family. {ECO:0000305}.
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DR   EMBL; D14156; BAA03196.1; -; Genomic_DNA.
DR   EMBL; X67785; CAA47995.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD06775.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71801.1; -; Genomic_DNA.
DR   PIR; F36892; F36892.
DR   RefSeq; NP_458734.1; NC_003198.1.
DR   RefSeq; WP_000720235.1; NZ_WSUR01000012.1.
DR   AlphaFoldDB; Q04976; -.
DR   SMR; Q04976; -.
DR   STRING; 220341.16505425; -.
DR   TCDB; 1.B.18.2.1; the outer membrane auxiliary (oma) protein family.
DR   EnsemblBacteria; AAO71801; AAO71801; t4348.
DR   KEGG; stt:t4348; -.
DR   KEGG; sty:STY4655; -.
DR   PATRIC; fig|220341.7.peg.4754; -.
DR   eggNOG; COG1596; Bacteria.
DR   HOGENOM; CLU_038343_4_0_6; -.
DR   OMA; RYEYKVG; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015159; F:polysaccharide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003715; Poly_export.
DR   Pfam; PF02563; Poly_export; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell outer membrane; Ion transport;
KW   Lipoprotein; Membrane; Palmitate; Polysaccharide transport; Porin; Signal;
KW   Sugar transport; Transmembrane; Transport.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           17..355
FT                   /note="Vi polysaccharide export protein VexA/TviF"
FT                   /id="PRO_0000022654"
FT   LIPID           17
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           17
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   355 AA;  38901 MW;  C0294EF775906F9F CRC64;
     MKKIIILLTT FFLLSGCTIP RAVFKSSLIN QDDPRYNLVE VTPTLKLSAP DTVPKTIVDP
     VFAANNWHWT SLAKGDVLHI TILSSGGAGY LSNNASGDRA DFENILVTDS NTVQVPYAGT
     IPVSGLDVTQ LADEIKKRLS RVVLNPQVIV TLTARTGAMV TVEGSGKTGR YPLEQSMNRL
     SHLLATAVAV ENTSTDMMEV HVTRQQHYFT ARLSDIYQYP GLDIALQPDD RITLRQVTEY
     VNVLGAAGVQ GKHALVQRHS SVVDALALAK GLNDNLADPQ AIFLYKHNEA EQAKQQMRKL
     NIYHVDMSQP NSVFLAQAIR VDNGDVIYIS NASLTDFAKV KAAFDSFLTR GTNSF