ID   VEXC_SALTI              Reviewed;         231 AA.
AC   P43110;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   05-DEC-2001, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Vi polysaccharide export ATP-binding protein VexC;
GN   Name=vexC; OrderedLocusNames=STY4653, t4346;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GIFU 10007;
RX   PubMed=8331073; DOI=10.1128/jb.175.14.4456-4465.1993;
RA   Hashimoto Y., Li N., Yokoyama H., Ezaki T.;
RT   "Complete nucleotide sequence and molecular characterization of ViaB region
RT   encoding Vi antigen in Salmonella typhi.";
RL   J. Bacteriol. 175:4456-4465(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: May form an ATP-driven Vi polysaccharide export apparatus, in
CC       association with the VexA, VexB and VexD proteins.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA03198.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D14156; BAA03198.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL513382; CAD06773.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71799.1; -; Genomic_DNA.
DR   PIR; H36892; H36892.
DR   RefSeq; NP_458732.1; NC_003198.1.
DR   RefSeq; WP_000467404.1; NZ_UCTX01000032.1.
DR   AlphaFoldDB; P43110; -.
DR   STRING; 220341.16505423; -.
DR   TCDB; 3.A.1.101.2; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; AAO71799; AAO71799; t4346.
DR   KEGG; stt:t4346; -.
DR   KEGG; sty:STY4653; -.
DR   PATRIC; fig|220341.7.peg.4752; -.
DR   eggNOG; COG1134; Bacteria.
DR   HOGENOM; CLU_000604_1_2_6; -.
DR   OMA; RMDGPAK; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015774; P:polysaccharide transport; IEA:UniProtKB-KW.
DR   CDD; cd03220; ABC_KpsT_Wzt; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR015860; ABC_transpr_TagH-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Polysaccharide transport; Sugar transport; Transport.
FT   CHAIN           1..231
FT                   /note="Vi polysaccharide export ATP-binding protein VexC"
FT                   /id="PRO_0000093123"
FT   DOMAIN          5..221
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         38..45
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   231 AA;  25570 MW;  D7DF55E7C98496C4 CRC64;
     MFGLLGCTRY FESDKGPRVV LDKTDFVMGY HEHIGILAAP GSGKTTLTRL LCGLDAPDEG
     DFIGLRGDAL PLGANSFILP GLTGEENARM MASLYGLDGD EFSHFCYQLT QLEQCYTDRV
     SEYSVTMKTH LAFAINLLLP CRLYIADGKL YTGDNATQLR MQAALACQLQ QKGLIVLTHN
     PRLIKEHCHA FGVLLHGKIT MCEDLAQATA LFEQYQSNQA TIQTEDYSFD I