ID   VEXD_SALTI              Reviewed;         434 AA.
AC   P43111;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Vi polysaccharide export inner-membrane protein VexD;
GN   Name=vexD; OrderedLocusNames=STY4652, t4345;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GIFU 10007;
RX   PubMed=8331073; DOI=10.1128/jb.175.14.4456-4465.1993;
RA   Hashimoto Y., Li N., Yokoyama H., Ezaki T.;
RT   "Complete nucleotide sequence and molecular characterization of ViaB region
RT   encoding Vi antigen in Salmonella typhi.";
RL   J. Bacteriol. 175:4456-4465(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: May form an ATP-driven capsule polysaccharide export
CC       apparatus, in association with the VexA, VexB and VexC proteins.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BexC/CtrB/KpsE family. {ECO:0000305}.
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DR   EMBL; D14156; BAA03199.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD06772.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71798.1; -; Genomic_DNA.
DR   PIR; I36892; I36892.
DR   RefSeq; NP_458731.1; NC_003198.1.
DR   RefSeq; WP_000431675.1; NZ_UCTX01000032.1.
DR   AlphaFoldDB; P43111; -.
DR   SMR; P43111; -.
DR   STRING; 220341.16505422; -.
DR   TCDB; 8.A.4.2.2; the cytoplasmic membrane-periplasmic auxiliary-2 (mpa2) family.
DR   EnsemblBacteria; AAO71798; AAO71798; t4345.
DR   KEGG; stt:t4345; -.
DR   KEGG; sty:STY4652; -.
DR   PATRIC; fig|220341.7.peg.4751; -.
DR   eggNOG; COG3524; Bacteria.
DR   HOGENOM; CLU_632666_0_0_6; -.
DR   OMA; QTHIRRD; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0009276; C:Gram-negative-bacterium-type cell wall; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR   GO; GO:0015774; P:polysaccharide transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005705; BexC_CtrB_KpsE_VexD.
DR   TIGRFAMs; TIGR01010; BexC_CtrB_KpsE; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell inner membrane; Cell membrane;
KW   Membrane; Polysaccharide transport; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..434
FT                   /note="Vi polysaccharide export inner-membrane protein
FT                   VexD"
FT                   /id="PRO_0000065781"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   434 AA;  49781 MW;  1A990D386D05F927 CRC64;
     MENSERIKKW KEERAKVAQE SRASRLQQKE DERALRQTEK SADAKSHHNP DAGWSATDAD
     SVRRASLVIK ERRVQQAKQS LRRLFLYIAL PLLVIMLMSW ILTSHFYSAD ATFIVQTDAS
     QDNFSGTSFF GAGNKMSEGF QVREFILSKE MMDRMEKELG FLSYFAQDDI ALFSRFHAPL
     GINDDPYRYY LSKVSVAVDI QQGMLRLNVK ARSAKQAEFF AQRILSFAEQ HVNTVSARMQ
     KERILWLEND VKSAQENLGA ARLELLKIQH IQKDIDPKET ITAIYQLIAG FETQLAEAKA
     EYAQLMVNGL DQNPLIPRLS AKIKVLEKQI GEQRNRLSNK LGSQGSSESL SLFEDLRLQS
     EIAKARWESA LQTLQQGKLQ ALRERQYLLI ISQPMAESDT TRYADGTKWL LFFVLLGITY
     LVTSLLITIR RMRE